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I learned a place got funded $1 million, and I figured out a way to fix the problem they're trying to solve a couple of years ago after learning about how to make beer using a yeast that cause ear infections after researching roman cures for otitis media. https://t.co/1t3V6dnDYl
Man, those Assyrians really did have some fucked medicinal superstitions eh? There's no evidence that rose hips do shit. Pouring an anti-inflammatory compound into ears to reduce tinnitus caused by ear infections? Hah, ancient civilizations were so dumb.https://t.co/bHJCt6vWcN
Galactolipids have an impact on funguses you say?https://t.co/J1facN486A https://t.co/kiw0kmGf6b
The Holobiont will be destroyed until inflammatory factors improve.https://t.co/47f8YHeg0Q
I could literally live the rest of my life doing experiments on mice for the funding level they got.https://t.co/I7TOy5mH8d
I have 99 ways to solve crohn's, but a medically validated trail ain't.... oh wait no, I found one."demonstrated antioxidant and anti-inflammatory activity [...] in conditions such as osteoarthritis, rheumatoid arthritis and inflammatory bowel disease." https://t.co/lwqq34ShJ9
The spice must flow.https://t.co/l4Ywk1Pfme
My beard is the longest it's ever been because I'm no longer suffering from itch associated with what I believed to be a fungal dermatitis."malassezia"https://t.co/amiP4KQ0mFhttps://t.co/VhLo2rww0K
Don't mind me, just rederiving healing salves from ancient alchemist traditions involving witch water.https://t.co/JM5dxZFM5e
@__________ur0 @dvdhhhh @nosilverv But if this the case, I expect people in ancient times to be using stuff that boost those pathways to enhance healing. Still digging into the terpene profile of medical herbs. I did find pinene (tar water?) enhances bloodflow and might work to enhance it.https://t.co/Vc3rgY9Yqd
I know strange things about how to kill fungus.https://t.co/3qqboAHLdK
Did you know Issac Newton experimented with barrels of horse urine?https://t.co/1bp32cKkSS
Why would using urine improve extraction of antifungal compounds?https://t.co/9khRHnT0F0
Crohn's Disease, what's that?https://t.co/rGqdokyIK7
So @Cortexyme Spent 17 millions dollars on on R&D in 2020 on a drug that targets the same biofilm pathway as a 1000 year old eye infection cure.And i'm getting spammed about it by a stock promotion account.https://t.co/ovRKmaPYc5https://t.co/g8QGdmCkJa
Malassezia, from a root system in a swamp?Ogres are complicated. Like onions. Do Ogres like onions? Do they have garlic breath?Is skunk cabbage a mustard?https://t.co/25WF4EJAlw https://t.co/r3aM8gMeIW
Malassezia Otitis can be fought with garlic oil."he results indicate that onion and garlic might be promising in treatment of fungal-associated diseases from important pathogenic genera Candida, Malassezia and the dermatophytes."https://t.co/B6WFCihuDqhttps://t.co/7V4uumTQZY
Of course, brassica. Thinks that make your farts stink.Sulfur demons.https://t.co/ZsLtIwmeec
Why do we call things "cabbage" when they aren't brassica?Symplocarpus foetidus -> "also swamp cabbage, clumpfoot cabbage, or meadow cabbage, foetid pothos or polecat weed" https://t.co/j1NXRaBgAZ
"It should not be eaten raw because its roots are toxic"https://t.co/4L9mnxK1eQToxic roots of a medicinal swamp plant with leaves that burn, you say? I wonder what the toxin is.https://t.co/V1XRUL5kFQ
Strong root systems in a stinky plant that generates it's own heat by breathing oxygen."The root system has been described as being “virtually indestructible” and may persist for decades and, possibly, even hundreds of years."https://t.co/04TNIBEnmx
> "Native Americans dried the leaves and used them to facilitate the healing of skin wounds."haha, another wound healing myth that probably is true.https://t.co/xb6dAsayQv
Poisoned apple makes you fall asleep. I'm sure that's just a fairy tale...https://t.co/7NYZW9KkiO https://t.co/HDrZT2gRA4
Talking with @nsreed about buying barrels of urea pellets and sourcing hibernating bear feces to see if this mangosteen peel + garlic + urea process would let me get swole.https://t.co/D6LYLNgj2jhttps://t.co/K6HVo0n50W
@nsreed Why Urea Pellets? Cuz I'd rather not drink piss while experimenting with enhancing proteins synthesis with gut bacteria fermentation during hibernation. https://t.co/VKXO0verGihttps://t.co/JFaxfGgq91
A great lens for this is to look at how organisms manage in terms of stocks & flows. Inputs, outputs, and storage.I learned recently that bears recycle urea during hibernation and turn it into muscle/protein. Urea comes from processing fats. Store fats help them w/ insulation. https://t.co/zaBBRxyCJ3
Oh cool, I can get 6 months worth of urine equivalent amounts of urea pellets for $105 (assuming 20grams a day). I wonder how long they can store for. https://t.co/UwwKYW8d9L
I'ma be powered by rocket fuel.https://t.co/x6GzrbhJpm https://t.co/wbZPY6teFh
Piss and vinegar.https://t.co/lFn8xdholc
Brian Eno's scenius, but it's Norbert Wiener's Network Celebrity being used to engineer a collective steering behavior by resonating ideas from 1950's cybernetics research, tied to the hip with rocketry, engineering a form of weaponized autism. https://t.co/UIQuShw8kA
Gonna order 500g of urea pellets next month to see what I can do with it. Worse case I just sprinkle it on the garden.https://t.co/XPOxjjPchs
Somehow went from an ingredient in energy drinks https://t.co/agM2eteL02 to methane in cows. And now I'm trying to figure out if I can use knowledge of rocket fuel to induced hibernation via ketosis related ammonia production.https://t.co/MSvc1gN54Y
Literally just trying to figure out what is in the energy drink that might be in garlic. Started out with seeing that Quercetin is high in Alliums. Then I'm thinking about lighting cow patties on fire. And here we are. https://t.co/5SCS5c87di
It might even fix climate change associated cow farts, lmao."These results confirm the ability of [garlic oil], [diallyl sulfide], and [allyl mercaptan] to decrease methane production, which may help to improve the efficiency of energy use in the rumen." https://t.co/CabE4cquOr
I was making a joke earlier that I might be able to use garlic to produce iron sulfide (pyrite) and in the process generate sulfuric acid to melt stones. https://t.co/avZxJrztST
And remembered that sulfuric acid is involved in hydrazine sulfite creation.https://t.co/6Bhy08TIqA
"bacteroides, bifidobacteria, clostridia, Proteus spp, and Klebsiella spp possess urease activity. Others, notably Esch. coli [dont], so that ammonia released by these organisms will be by deamination of substances other than urea."https://t.co/QnSqKF8VoEhttps://t.co/JmQPr1FoWp
That paper suggests the ammonia production is pH dependent. So I gotta figure out a way to get the pH level of a bear's ass during hibernation.https://t.co/CjyoF3Gdbe
Looks like graphene causes upregulation of anti-inflammatory compounds, so that might be bad to have long term."These results clearly indicate that graphene may cause adverse effects on the intestinal microbiome at the doses equal to 100 μg/mL."https://t.co/jyxIzvjtaq
Someone on /r/microbiome/ asked about use of cannabis as it relates to fungal infection. I couldn't answer directly, but did end up summarizing the role of fungus as it relates to Multiple Sclerosis and IBS/Crohn's & possible mechanisms of action.https://t.co/8iaQ4nZrtS
Sleeping on an idea.https://t.co/BWnMR9aT4N
I read a paper in my dream describing how overlap between garlic's impacts on gut bacteria and its impacts on nerve regrowth related to an IRL finding aroud THC+Akkermansia muciniphila.I keep going to search for tweets I wrote about it. I keep forgetting it was in a dream.
And letting it stew.https://t.co/rvyjXEjeqJ
"impact of antidepressant treatments on microbiota structure and metabolism remains underexplored [...] human microbiota such as Akkermansia muciniphila, Bifidobacterium animalis and Bacteroides fragilis were significantly altered"https://t.co/Pz5VlgewEthttps://t.co/yBOggQCH45
An idea bubbles up.https://t.co/65lQDS5jnD
@GentleMutt A garlic extract of Allicin might "help with digestion" because it seems to be metabolized into cysteine, which can further be turned into Taurine. Taurine is interesting to me right now b/c of impacts on Gaba and role in bile acids.https://t.co/j47Uf69Xfo
It smelled like garlic.https://t.co/lhVZPfw43V
"Unlike many other microbes in your gut, A. muciniphila doesn’t rely on you to feed it. This gives it a slight ecological advantage. Instead, by using your mucin reserves, [...] thrive even if there are no nutrients in the gut. So, even if you’re fasting," https://t.co/vrcKlUjR6P
Does A. Muciniphila help with tryptophan metabolism?"The scientists also found that ALS mice given A. muciniphila had higher levels of a bacterial metabolite called nicotinamide compared with those that didn’t get the microbial species."https://t.co/STGyZbjV0R
@The_Lagrangian @mfwells5 hmm. HMMMMMM."the scientists transplanted those species, [...], into mice without any gut microbes, and found that two species made ALS symptoms worse—Ruminococcus torques and Parabacteroides distasonis. Meanwhile, A. muciniphila made symptoms better." https://t.co/v7ZxdqTB60
My hair is so pretty :3https://t.co/AjjGubUxVw
I rate my insights in LOLs per second. "Our results on a limited number of individuals show that Malassezia spp. associated with dandruff varies in different regions of the country and the density of yeasts increases with severity of disease."https://t.co/sbVTAOwGN1
"the spatial organization of the gut mycobiota is associated with host-protective immunity and epithelial barrier function and might be a driver of the neuroimmune modulation [...] through complementary Type 17 immune mechanisms."https://t.co/NtzFow6cdshttps://t.co/gZ3Wrskqwm https://t.co/spmDpfNzmR
What is a mycobiome?🤣https://t.co/FHEgf4xjhS
So we are literally at the "preclinical phase" of exploring the mycobiome's role in gut and host immunity?That's amazing.https://t.co/0mlVNVQZhZ
What else is in that dog shit FMT that we haven't been paying attention to?https://t.co/TQOnASwY4l
@MMMalign @joewittebrood @DesidErratum And sitting next to it, from 2 years ago."The Potential Role of Gut Mycobiome in Irritable Bowel Syndrome"https://t.co/4OtjWRNIDSYou wouldn't believe how many people report fatgue and fatigue reductions from FMT for IBS/IBD...
We get signal?https://t.co/McO3DEBhMo
@yuukoposter @leaacta Thing everyone is missing is the Lipopolysaccharide associated gut permeability response is probably the body trying to regulate the mycobiome, not bacteria. LPS triggers fungus to start metabolizing things, so it's most likely acting as a signal. https://t.co/LxNRMRoJl9
Host compatible.https://t.co/NQC7BVCJqX
Host Compatible"answer that question would be to try swapping out the genetic material – basically, disable a gene in yeast, then replace it with the human version [...] roughly half of these yeast genes could be readily replaced with the human version."https://t.co/wImkYXDqd6
I have the documents.https://t.co/LTKAsXK1Hb
I think @nsreed wanted to build an algae bioreactor?100g of USP grade urea crystals for ~$25!https://t.co/aN77zfUDSehttps://t.co/8yLK7z3NjD
"systemically introduce the recent knowledge about multi-dimensional fungal dysbiosis associated with IBD, the interactions between fungus and bacteria, the role of fungi in inflammation in IBD, and highlight recent advances" https://t.co/5bzQo1aftJhttps://t.co/EmIjPMI4g8
Know what is what is fun about FMTs? It comes with it's own mycobiome too.https://t.co/xkG3F6a9KB
@andrewsyc @naval A Canadian company just got 1 million dollars USD to make a drug to fix a gut fungus they suspect cause crohn's disease.I figured out how to to cure it with an oil from a rosehip after reading about how romans dealt with ear infections commonly seen in autistics.
"highlight the importance of fungal interactions with intestinal bacteria and with the immune system. Although most […] focused on their role in disease, we also consider the beneficial effects of fungal colonies" [JUL 2023]https://t.co/JsMR8XATzRhttps://t.co/CIvJfmUSnK