🧵 View Thread
🧵 Thread (67 tweets)
There's a massive interest in this in the literature. I've been seeing it in the context of autoimmune disorders. https://t.co/c4BlbfryOFI found that interesting. https://t.co/DDTaStHfa4
What's kind of weird here is the idea of screening for psychosis, given that one of the major autoimmune disorders is rife with them. https://t.co/qxBLbw2fILhttps://t.co/qObXvFmRAFIt doesn't add up to me.
This seems to conflict with the idea of using it to treat multiple sclerosis. https://t.co/YGwGBx93tD
One of the funny things I found in my research here is that if we hadn't banned LSD research in the 60's we might have a much better idea of how this stuff interacts with autoimmune issues.https://t.co/HyX15cuiFs
I'm getting a kick out of this space of ideas though. The idea that modulating gut bacteria may play a major role in the disease states of people with autoimmune seems to be also a method of action of psychedelics.https://t.co/8Mpawfngjg https://t.co/SpoAdoHf2G
"Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in the excitatory neurotransmission" https://t.co/sZxmMV3ySf*cracks knuckles*https://t.co/MyHLa7zmpm
*cough* https://t.co/f1UWzmOxbw
imagine If I cure my allergies by eating dog shit... because I steelmanned a theory about EMF and guessed that it was an alternate model for explaining unknown metabolic and oxidative stress factors related to gut microbiota problems. 🤣https://t.co/tKjeZOC26s
@theolearns @DrJackKruse It would be really cool if it is a mix of EMF and microbs though. I'm not discounting the theory outright, only that it may be not the only answer. Take for example this study https://t.co/LEscd2GuXf vs finding in microbiome's role in allergies. https://t.co/ExZyCd9DLo
TL:DR; we should be able to roughly tell if someone will have "Hallucinogen Persisting Perception Disorder" by smelling their farts.https://t.co/1seKoCfAB9
Did you know mTOR plays a role in allergic reaction resposnes?What's the deal with FMT fixing some people's peanut allergies and autistic/adhd symptoms lessening when you're outside in the sun and interacting with cow shit?Could they be related?https://t.co/Syd1EogDxS
One day I will have my underground lair of hibernating chipmunks and I'll be able to prove one way or another how much the gut and EMF play a role on oxidative stress tied to mTORC1 and diabetes https://t.co/fPVqWdgvkqhttps://t.co/YXThFDYhw4
@Stewbid1 @NgoloTesla @Grimhood My plan is to build a bunker underground, isolate it from acoustic vibrations using springs, and coat the wall with iron rich dirt and carbon infused plaster until I can't detect any gauss.https://t.co/7RsPA2DJVkCheaper than copper and can get he same effect.
Like some kind of mad man hiding on a deserted island.https://t.co/XvGQB3MvNG
@mouthofmorrison You can block RF by building a bunker of activated carbon using impregnanted clay similarly to what they build fancy climate controlled wine cellars out of. But then you show up as a black void. This lets you hide from radio tomography https://t.co/ugym4ZATVH
Sorry. I'm bored right now.https://t.co/0w1IKE71jX
Thinking about Hallucinogen Persisting Perception disorder reminds me of how people to trip balls talk about seeing clowns.https://t.co/1lbk4cPewj
Ah neat, Joe Rogan took DMT saw the same clown I did when I was 3 years old and became petrified of IT."only crazy people do drugs"https://t.co/fgPBvL2HOtOr you have hypoxia from sleep apnea, or a maybe a mitochondrial dysfunction tied to HIF-1 α.https://t.co/wVuJPEnB41 https://t.co/ukS0oQW0T6
Honestly, it just sounds like they're getting some form of synesthesia effect that coincides with similar cross wire firing in memory signaling, which is then framed as 'subconscious'. https://t.co/vaaTAAwnhzhttps://t.co/5QScYC4j2a https://t.co/6pnctSWHRF
I should find one of those honkey horns to attach to a wheelchair. Then I can more completely embody the clown. 🤡https://t.co/9n3CsQGxKC
@Brainclinics @elonmusk One of my college friends works at Duke university where they pioneered a lot of these BMI ideas by studying cognition and attention/motor control.I have Multiple Sclerosis and I think it would be fun to drive a robotic wheelchair.https://t.co/XHRkDVwkDo
The mask puts you in touch with your subconscious desires! https://t.co/T4Avcg2Q5i https://t.co/IJYPPlzCDk
Good companion thread to that Mad in America post.https://t.co/3I3y3zjaJs
Lots of weird stuff seems to be happening in this space. I don't' think "HPPD" is a good diagnostic label given the variety of responses it seems to induce. Maybe there should be more subtypes?https://t.co/tlnEVjpyNb
"A case report described a patient with a prior history of cannabis, alcohol, and LSD sporadic recreational consumption, who developed LSD-induced “Alice in Wonderland Syndrome” and HPPD after discontinuation of all substances"https://t.co/LYvTaNxy1Ehttps://t.co/r0PWAQxtDl
How can I have HPPD symptoms even though I've never taken anything psychedelic? Long term second hand Cannabis smoke in childhood maybe?I've had strange hallucinations since I can remember.https://t.co/MsHvGsg0Q6
I wonder if this phenomena is like the weird pseudo-differentiation between psychosis and synesthesia?https://t.co/0cZbjJPPPb
Even drugs not considered hallucinogenic are sometimes able of producing some of the symptoms."Visual snow syndrome after start of citalopram—novel insights into underlying pathophysiology"https://t.co/tvdbI4ktMY
"While previous research has mainly focused on the central nervous system including the immune system and the neuroendocrine system, I propose a central role for sleep and the microbiome in the effects of regular and low doses of psychedelics respectively"https://t.co/ZGZ3qdpc8v
"Likewise, I recently did a herbal anti-fungal/microbial treatment which resulted in not having visual snow for some days. Thus, I believe some visual snow may be caused by a bacterial or fungal overgrowth." https://t.co/qImbrmbEFN
Hmmm."As both azoles and more recent antifungals are metabolised by the P450 enzymatic system in the liver, here we review the potential of clinically meaningful interactions between antidepressants and azoles."https://t.co/HvV39HzkkP
"impact of antidepressant treatments on microbiota structure and metabolism remains underexplored [...] human microbiota such as Akkermansia muciniphila, Bifidobacterium animalis and Bacteroides fragilis were significantly altered"https://t.co/Pz5VlgewEthttps://t.co/yBOggQCH45
Someone on /r/microbiome/ asked about use of cannabis as it relates to fungal infection. I couldn't answer directly, but did end up summarizing the role of fungus as it relates to Multiple Sclerosis and IBS/Crohn's & possible mechanisms of action.https://t.co/8iaQ4nZrtS
I wonder if anyone has ever tried to intentionally DIY FMT from fecal matter from a schizophrenic into themselves to explore the experience.That would take a psychonaut with some *ahem* guts. (huge risk of parasite infection)https://t.co/zlryOBF4e6
@alt_kia @sashachapin @literalbanana I've been actively trying to find ways to get into medical studies on shrooms (not just psilosybin) because of suggested impacts on neurogenesis.Good chance this will make me see the fly god because I already suffer from minor parasite hallucination. I do not want that at all.
"Together, our findings suggest that the SCZ microbiome itself can alter neurochemistry and neurologic function in ways that may be relevant to SCZ pathology." https://t.co/yxMvuFcaBC(This seems the same as the study where they put autistic poop in mice, lol)
Muh "Childhood Schizophrenia"https://t.co/HDJ1fIm0mu
I regret to inform Asperger's isn't real. You actually mean to say Asperger's monster. Or rather Eugen Bleuler's "childhood schizophrenia", or Leo Kanner's "Autistic disturbances of affective contact" but viewed thru lens of medical billing and eugenics https://t.co/nZwyLsIA4w
What is in my pee?https://t.co/ki31Yw4mNj
@pee_zombie @ecree429 @esrtweet That autistic and schizophrenic types seem o pee out a salt of DMT suggests to me something very fascinating is happening.Since DMT is made from melatonin, and melatonin is made from Serotonin. What happens if I boost serotonin via gut bacteria?https://t.co/6r49uS6wrD
That sigma-1 grindset.https://t.co/a7Dtse88De
I have no idea what that means, but I can make up associations between similar phenomena to link ideas together. That's what we do w/ diagnostic labels all the time -> draw sand lines to divi people up into buckets so we can treat them.Apophenia is great. *mic drop*
You use acid to dissolve the self-other boundary.https://t.co/GtFa7LniX8I'm dissolving boundaries between words to undermine silos of thought by leveraging memetic/comedic amphiboly (https://t.co/i4NoA0yKYV)We are not the same.https://t.co/XPxsgFikEL
Flashbacks are weird. @atypicalhippy suggested they might be trauma driven?I wonder how much overlap there is between psychedelic flashbacks and PTSD phenomena.https://t.co/8gyWw7kPerhttps://t.co/BFSIPexsb1
Next, you'll be telling me how consuming one of primary precursors for the production of endocannabinoids (one that also contributes to feeding the gut bacteria responsible for serotonin production), ends up protective against PTSD.But muh stress tho. /shttps://t.co/iHI4FmwuJu
Something that fascinates me is how many of the traditional usage of psychedelics seem to be using things that act as MAOIs. Like alcohol seems to do. https://t.co/MnSOTKg4INhttps://t.co/Q3Oa00bh9e
We've basically recreating that with some of our modern drug combinations. Like Tianeptine & MAOIs https://t.co/T1geszoQ12
Many of the psilocybin mushrooms seem to have MAOI effects too. Which would be lost if you just take a synthetic form.Likewise, many traditional uses involve having a shaman or similar trusted care-taker figure walk you thru the process.
I taught myself adhoc visualization techniques when I was 6.Makes sense that people who don't have these skills end up running into distressing situations when seeing the clowns in their subconscious. https://t.co/QFnpvpjs7Ohttps://t.co/0arfOiP9TK
It's fun watching monoamine hypothesis of depression slowly die."Both SSRIs and tianeptine are clinically effective; however, their opposite modes of action challenge the prevailing concepts on the need of enhancement of serotonergic neurotransmission." https://t.co/07UiWXgpCv
Tired: unprocessed trauma from a bad trip.Wired: haunted by a mære.Inspired: laughing at how bad the sleep clowns are at trying to be funny.https://t.co/9LKu2921gb
"Tagliazucchi isn't just interested in drugs and dreams, though. He'd like the mine the vast amount of human experiences that people have dumped onto the internet for greater understanding of how many experiences humans can have."https://t.co/yX0rNuKkJC
Creativity is just Weaponized Apophenia.https://t.co/zLpoZp1e2I
To sleep perchance to dream. Aye, there's the rub."Here, we show that the brain activity common to the twilight zone between sleep and wakefulness (nonrapid eye movement sleep stage 1 or N1) ignites creative sparks."https://t.co/OI8UlOk0bIhttps://t.co/rxAXHFL0IC
Its not that you get small, but your perception of the world shifts, so it looks different than before.When my iris flutter due to problems with my CNS, its not the world that vibrates, but my view of it.https://t.co/CmJCfD4Cpx
"the development team thought it would be interesting to have Mario grow and shrink by eating a magic mushroom, like in Alice In Wonderland, where she ate a mushroom to make her grow after poison shrinks her" https://t.co/LYE6adf5PKCollective dreamworld.https://t.co/YY5dq2O3MN
The flickering phenomena is really annoying because so much western lighting is driven by PWMThe eyes responding to CNS issues is one aspect of a much more complicated pupillary response mechanism.https://t.co/VUa4sn2v2t https://t.co/flooyWBnm7
"only appeared during LSD consumption and continued after LSD suspension, namely, Hallucinogen Persisting Perception Disorder (HPPD) [...] not cause a major functional impairment but provoked sufficient worry and concern due to its persistent continuation"https://t.co/qmu3PoAYg3
I'm thinking the Alice-In-Wonderland thing may be another symptom that is just bucketed within the HPPD label. More so, it might be worth separating out as a specific issue because the underlying causal pathway ought to be predictive of a unique factor in the individual.
My hunch is it's about a divergence between the brains' expectation of field-of-view and the actual state of the eye dilation that is normally under automatic control.It's a very odd sensation. Feels kinda like this: https://t.co/4oypRsMQnq
I don't know why I get that without psychedelics, or what aspect of my biology causes it, but it does happen to coincide with immune state and my odd circadian rhythm.https://t.co/GXK1o8AzDi
There's something complex going on w/ how my body responds to stress and CO2 that is triggering dynorphin, but happens during sleep apnea, and would be mimicked by immune activation/cytokine's action on dynorphin receptors.https://t.co/rRsAVsvu2yhttps://t.co/7VL9gDYd5j
Likely also tied to vision-narrowing phenomena I get during autistic overstimulation/meltdown state. My current hunch is this associated with stress responses acting on something tied to metabolic functioning / adrenaline.https://t.co/bj658DKn44
If what we are seeing is something like what @BasicMorality describes as "Dynorphin Theory"https://t.co/Ew7BPpDuPk then maybe we should start looking at the long term shifts in the opioid system for an explanation for HPPD? https://t.co/j8dyK1SNpH
These prolonged HPPD states may actually be via secondary choline related shifts that hit smooth muscles in the eyes and brain. Which might explain the variability in responses.We might expect drugs like naloxone to counter it?https://t.co/uRlAcH5TkD
Which may also explain the anti-depressant effects of LSD that people report. Maybe its not the serotonin system itself, but something else that it happens to regulate. https://t.co/CWre03eaGr
I know there has been some research exploring ibogaine to treat opioid addictions. So that might be an avenue to explore for more possible connections. https://t.co/L3FfH5zfde
There are interesting connections between ibogaine for opioid dependence and HPPD induction, so figuring out why this occurs in some people and not others may be quite valuable in the west's quest to end the opioid epidemic. https://t.co/PlCNBDTvV4
Did you know that gut bacteria can make https://t.co/jEiLU50shH modulate https://t.co/zBhpLzY8xoand usehttps://t.co/QIM8cidAO9choline?Kinda sus.
I wonder why ayahuasca makes some people vomit, but not others."It’s certainly possible that psychedelics may exert their lasting effects through alterations to the gut microbiome, but further research is needed to test this hypothesis." https://t.co/bJ894vJxDl
I found a vice article talking about someone having HPPD but they attribute it to migraines."In the most recent case Barton diagnosed, this was the story—she became aware of "drifting rain" in her vision after coming off SSRIs."https://t.co/8G0pa0aW1H
I wonder if the insects I was seeing out of the corner of my eye were this phenomena. I had it since I was a child tho, and no drugs to speak of. https://t.co/jp3NOBOXDv
Sleep drunk?"Visual hallucinations are more common, with imagery of insects, animals, people, or disembodied heads. They may occur only with eye closure and tend to be fragmentary, lasting minutes at a time over several days." https://t.co/3wpw4zN9uM
Hug someone today if you can, even if it is yourself.Squeeze yourself tight and relax. Its going to be ok.https://t.co/y5x0kE7W0F
SSRI withdrawal symptoms.https://t.co/D82W2xnMw1
if I hadn't taken the SSRI that fucked me up, I wouldn't be where I am now, talking about HPPD and opioid/alcohol function as it relates to psychedelics and cross pollinating these ideas with the microbiome.https://t.co/ZpQu6J5Mun
Is HPPD and flashbacks the same thing as trauma flashbacks?"The similarity in neuroreceptor physiology for both LSD and serotonin suggests that the LSD flashback syndrome may be induced by these drugs in patients with a history of LSD abuse." [1994]https://t.co/Mw2QAklbat