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🧵 Thread (60 tweets)

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UltimApe@ultimapealmost 5 years ago

"In 8th grade I read [double helix]. From that I had a vision; I was like: I wanna genetically engineer lizards to turn into dragons." — @The_Lagrangianhttps://t.co/xVdTNO9Xi0 https://t.co/DD5kSadXPq

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UltimApe@ultimapeabout 6 years ago

I was told as a child that I will never be able to be a yoshi.I refused to believe them.https://t.co/OxWpERI3zr

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11/16/2020
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UltimApe@ultimapealmost 5 years ago
Replying to @ultimape

"[...] lizards with wings would be sufficient. I would consider that sufficiently dragon-y to have made a dragon."https://t.co/u2HxWX2lwj

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UltimApe@ultimapeover 5 years ago

Kid's asked the damnedest things."sometime in the future we'll know enough [...] to identify the part of the bat genome that calls for wings [...] and put it into the human genome."https://t.co/EGm2M0AG8t https://t.co/rYjs5204Cw

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11/16/2020
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UltimApe@ultimapealmost 5 years ago
Replying to @ultimape

"Limestone is high in calcium. Calcium when mixed with stomach acids, would form hydrogen. Hydrogen is lighter than air thus giving the lift you talk about. Something like a blimp.What? You got fire inside you and you go up! that's all you need to know." https://t.co/wUkri3fuHf

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11/16/2020
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UltimApe@ultimapealmost 5 years ago
Replying to @ultimape

TL;DR: Dragons belch fire because they float like a manatee in the air. The wings are for steering. They're basically bird balloons.https://t.co/1ppPd4YK1x

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UltimApe@ultimapeabout 5 years ago

I wondered if the gut microbes of the manatee impact hair development at the same time as they help it float with farts. Like one does.https://t.co/k5hjSuQIEH

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11/16/2020
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UltimApe@ultimapealmost 5 years ago
Replying to @ultimape

Get on my level.https://t.co/7jZGOrgo5F

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11/16/2020
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UltimApe@ultimapealmost 5 years ago
Replying to @ultimape

The harder problem with growing wings is that you tend to get wyverns - like how bat & bird forelimbs are their wings.Would need to do something interesting to promote a second set for arms.https://t.co/mSfRS1peYF

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11/16/2020
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UltimApe@ultimapealmost 5 years ago
Replying to @ultimape

I think a lot about trying to activate ancestral genes in the chicken to turn it into a dinosauresque "Chickenosaurus": https://t.co/1v97tcsMxTAnd would be possible to create an alternate evolutionary timeline like discussed in this slice-of-life anime?:https://t.co/mH1RdsoH4s

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UltimApe@ultimapeabout 7 years ago

"However, the idea of a world in which humans have just four limbs is absurd..."https://t.co/blIJuG3GjG

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11/16/2020
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UltimApe@ultimapealmost 5 years ago
Replying to @ultimape

Given that birds already have lightweight structural elements and an acceptable digestive tract (+ gastrolith mechanism) conducive to flight, it seems more likely to get a dragon-like creature by modifying a chicken vs a lizard.https://t.co/HU2kCGEOei

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11/16/2020
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UltimApe@ultimapealmost 5 years ago
Replying to @ultimape

A yoshi that spits fire, has wings, and can inflate to float is literally cannon in the Mario universe.https://t.co/1cGvDBY67g

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11/16/2020
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UltimApe@ultimapealmost 5 years ago
Replying to @ultimape

Yoshi's having shells on their back, and koopas with bird-beaks?Phylogenetically speaking, this may even make sense!https://t.co/DXIRwjxeZWhttps://t.co/M6UmW843JY https://t.co/nGXrxlmIak

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UltimApe@ultimapealmost 9 years ago

@The_Lagrangian @fire__exit @literalbanana techncially, turtles/tortoises are more related to birds than dinosuars: https://t.co/g3ngq0HJ4t

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11/16/2020
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UltimApe@ultimapealmost 5 years ago
Replying to @ultimape

It is amazing how a book or a game from childhood can influence. I was smitten with the Maxis games:SimEarthSimParkSimLife: The Genetic PlaygroundUnnatural SelectionWill Wright knows a lot about genetics & artificial life.https://t.co/4FYTiyoNrN

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11/16/2020
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

Tired: Elon Musk creating Jurassic park.Wired: Elon Musk making a fart flying Yoshi to advertise his blimp industry.Bunch of options for blimps. My vote is methane.https://t.co/0sgQ0SivMyhttps://t.co/BUCVjhygny

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4/11/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

What frequency of laser will heat up and melt thru a reflective Mylar layer used to hold in lifting gasses?Or is the dust on the surface enough to cause problems?https://t.co/x9jyqu4Mf6

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UltimApe@ultimapeabout 9 years ago

Balloons existed as a form of human flight well before first powered plane by wright brothers. Very economical for long term surveillance.

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4/11/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

Oh hey, I should investigate if self cleaning plastics repel dust https://t.co/ZKXnQeiTBR

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4/11/2021
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UltimApe@ultimapeabout 4 years ago
Replying to @ultimape

If I figure out how to become a dinosaur, do you think the scales will make people think I'm one of them lizard men from the center of the earth?https://t.co/IUlqVmt8N8 https://t.co/o09jWuGZAG

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7/5/2021
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UltimApe@ultimapeabout 4 years ago
Replying to @ultimape

"This is a flammable gas that smells like rotten eggs. It is found in crude oil. When hydrogen sulfide and iron get together [...] the result is iron sulfide. Combine it with air and you’ve got an explosive mix."https://t.co/EOrtobSM8K

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7/25/2021
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UltimApe@ultimapeabout 4 years ago
Replying to @ultimape

https://t.co/xGFf1pC0re https://t.co/dLuDWi50jp

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UltimApe@ultimapeover 6 years ago

Link all the weird ideas together to maximize the most amount of gaseous windbaggery.Then light it on fire.https://t.co/zMuzmQ3O4a

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7/25/2021
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UltimApe@ultimapeabout 4 years ago
Replying to @ultimape

In playfully exploring the space of Sonic Hedgehog regulatory gene (and associated developmental pathways), my friend @nsreed helped me figure out a plausible way to trigger human germline cloacal mutations. Next I gotta figure out the platypus.https://t.co/uB6tyeVv0D

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UltimApe@ultimapeabout 4 years ago

@nsreed These are the genes!https://t.co/KfQfryZ9LC

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8/1/2021
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UltimApe@ultimapeabout 4 years ago
Replying to @ultimape

@nsreed For my next magic trick, I'll be investigating how Knuckles, an ant-eating mammal (Echidnas), can lay eggs.https://t.co/ZJSwFjDWQMDo you know dae way my brothas? https://t.co/jAKxz67VC0

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8/1/2021
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UltimApe@ultimapeabout 4 years ago
Replying to @ultimape

"What if the impact of that meteor created a parallel dimension where the dinosaurs continued to thrive and evolve into intelligent, vicious, and aggressive beings... just like us? And hey, what if they found a way back?"https://t.co/P8gVU8M9W6

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8/1/2021
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UltimApe@ultimapeabout 4 years ago
Replying to @ultimape

You ever wanna figure out how to genetically engineer a bacterial probiotic to boost the development of a bird's intelligence by helping it better process bile acids?https://t.co/tyokpxlkx5

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8/1/2021
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UltimApe@ultimapeabout 4 years ago
Replying to @ultimape

"police detective […] is paired with an anthropomorphic Tyrannosaurus […] to find the killer of dinosaurs and other prehistoric animals leading them to a ruthless billionaire bent on killing off mankind by creating a new ice age."https://t.co/HuSBT6rAqThttps://t.co/USJgownmp9

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UltimApe@ultimapeabout 7 years ago

Fun fact. People who feel the body is a sacred temple of god are absolutely disgusted by Sam Altman's investment. Assisted suicide is a sin etc...So of course the dailymail is using it as to pump out outrage bait for that group.

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8/1/2021
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UltimApe@ultimapeabout 4 years ago
Replying to @ultimape

Watching this now.https://t.co/LFyPS4wq41

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8/1/2021
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UltimApe@ultimapeabout 4 years ago
Replying to @ultimape

¿Por qué no los dos?https://t.co/vM414117dE https://t.co/OrGkfwmUw6

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UltimApe@ultimapeabout 4 years ago

"In this review, we will also highlight some clinical trials that use the Shh pathway as a target for treating brain cancer."https://t.co/CAsIwZOqt3https://t.co/4InV207U76

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8/1/2021
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UltimApe@ultimapeabout 4 years ago
Replying to @ultimape

GF walks in. I ask if she wants to watch people review Dinosaur movies from the 90s.She asks if I'd ever seen Denver.https://t.co/LjKDVp5rKl https://t.co/HE4tuohVpA

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8/1/2021
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UltimApe@ultimapeabout 4 years ago
Replying to @ultimape

Can you imagine being influenced by memes stemming from the fancies of the deluge of rich middle class museum goers all flocking to see The Hadrosaurus Foulkii in the 1850s?https://t.co/5bIq9AyTZv

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UltimApe@ultimapeabout 7 years ago

A more real world example of this effect happening due to networks - consider Mary Anning's story https://t.co/ywhENYHI2U and how her discoveries https://t.co/qLWWXciZ4S filtered up thru into Charles Darwin's theories of evolution. https://t.co/LcIjjPqFVL

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8/1/2021
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UltimApe@ultimapeabout 4 years ago
Replying to @ultimape

I mean, its not like our species has been mining stuff out of the ground for centuries. Do you think the coal miners estimated to be about 20,000 years old ever found giant dragon fossils? https://t.co/T6TAWNxnEj

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8/1/2021
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UltimApe@ultimapeabout 4 years ago
Replying to @ultimape

Can you imagine if dinosaurs thought they were from another place besides earth, then find human remains and it seeds great doubt about their trajectory thru the cosmos?https://t.co/UF5QLAHW6K

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8/1/2021
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UltimApe@ultimapeabout 4 years ago
Replying to @ultimape

"Certainly the building blocks are there.Bipedal. Grasping Hands."https://t.co/BwOJcxMoxPhttps://t.co/wKEGqtH6Et

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UltimApe@ultimapeover 9 years ago

What's going to fill our niche on planet's surface after we annihilate ourselves / become spacefaring?

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8/1/2021
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UltimApe@ultimapeabout 4 years ago
Replying to @ultimape

Oh hey neat. Mary Anning was apparently one of the driving forces behind paleontology trends in France. Makes sense!On literally trying to find flying dragons. https://t.co/M767Upm0RPhttps://t.co/quicQ9MCmL

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8/3/2021
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UltimApe@ultimapeabout 4 years ago
Replying to @ultimape

There is apparently a movie made about Mary Anning."Like palaeontologists struggling to reconstruct entire vanished worlds from stony scraps, sketching Anning’s life relies on historical fragments."https://t.co/Ebzsg9AeMgGreat review thread:https://t.co/zHNPLrcxec

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8/4/2021
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UltimApe@ultimapeabout 4 years ago
Replying to @ultimape

There's a bacteria shitting out acids in some iron mines. Its fascinating."co-author of the study said the microbe gives off sulfuric acid, a chemical that eats into heavy metals and causes deadly concentrations of acid-metal pollution in mine runoff."https://t.co/L7ykcPkEa0

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8/6/2021
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UltimApe@ultimapeabout 4 years ago
Replying to @ultimape

One that eats steel"One of the specialist engineers tackling the problem said he was "horrified" by what he had seen. "The bacteria can go through sheet piling like a knife through butter," said Craig Donald, director of CorrOcean, in Aberdeen."https://t.co/zuLeoxo0Tz

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8/6/2021
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UltimApe@ultimapeabout 4 years ago
Replying to @ultimape

Gut bacteria?"When they take in heavy metals like lead and cadmium, they crystallize these ions in their guts. [...] With this special cleanup capability, pill bugs survive in the most contaminated sites where most creatures can’t."https://t.co/zH3gAvQWVe

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8/6/2021
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UltimApe@ultimapeabout 4 years ago
Replying to @ultimape

"While this may seem like a great way to clean up contaminated land, the heavy metals do not actually leave the area. Instead they are just concentrated in the pill and sow bugs. Once the bugs die, those toxins would likely go back into the soil." https://t.co/5Xmwsfc23F

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8/6/2021
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UltimApe@ultimapeabout 4 years ago
Replying to @ultimape

"reviewing the use of isopods as test organisms in soil ecotoxicology. It provides an overview of the use of isopods in laboratory toxicity tests, with special focus on comparing different exposure methods, test durations, and ecotoxicological endpoints."https://t.co/tjHhOZQl96

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8/6/2021
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UltimApe@ultimapeabout 4 years ago
Replying to @ultimape

Lots of animals eat metal. We don't think about it that way, but calcium is a metal.https://t.co/DtygmBx7HQ

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8/6/2021
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UltimApe@ultimapeabout 4 years ago
Replying to @ultimape

Isopods apparently really like limestone.https://t.co/IO7ZJzez6o

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8/6/2021
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UltimApe@ultimapeabout 4 years ago
Replying to @ultimape

Thinking about dragons again.https://t.co/AYJuKU89oR

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UltimApe@ultimapeover 10 years ago

Something investor profit something startup something dragons something unicorns.OMG PUSHEEN!http://t.co/9ZPEi3OMUG http://t.co/pLF0XufZiL

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9/1/2021
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UltimApe@ultimapeabout 4 years ago
Replying to @ultimape

In particular, how to get a 3rd pair of limbs that I can mutate into wings? https://t.co/tLu4p80fb4

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UltimApe@ultimapeabout 5 years ago

I wake up like this sometimes, but it's more like "ah, excellent, you're up. Inquiring minds want to know if it's possible to regrow limbs torn off in a tug of war"Wolverine style. https://t.co/WJSol1SnrF https://t.co/SAvZmYuR0m

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9/1/2021
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UltimApe@ultimapeabout 4 years ago
Replying to @ultimape

So that bit where I learned about echidnas actually paid off. And thanks to some interesting findings on royal jelly induction of pluripotent states (thanks @mmmalign ) I might even have a bead on how to induce it with microbiota. https://t.co/9ig1NnPxBhhttps://t.co/4wanmDeCES

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UltimApe@ultimapeabout 4 years ago

Sonic Hedgehog gene seems involved in limb regeneration.https://t.co/X91vgSW7Me

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9/1/2021
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UltimApe@ultimapeabout 4 years ago
Replying to @ultimape

soon.jpghttps://t.co/pSpNoW6HeE

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UltimApe@ultimapealmost 5 years ago

Bact(eria)a tankhttps://t.co/DXQPo6e15phttps://t.co/5hZGoxP1Lz

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9/1/2021
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UltimApe@ultimapeabout 4 years ago
Replying to @ultimape

Medical Machine, lol. https://t.co/fAIspDutW3

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9/1/2021
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UltimApe@ultimapeabout 4 years ago
Replying to @ultimape

Gonna talk to my mom about what she thinks about transhumanism, and what would she think if I become a lizard person. (scalie)https://t.co/wzLvbFlVAI

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UltimApe@ultimapeabout 5 years ago

Combining CRISPR together with stem-cell creation, and then combining it with collagen scaffolds to regenerate fleshy bits. That's going to really freak out my mom now what she understands a bit of what i'm talking about.https://t.co/s1EQkWy6Lm

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9/1/2021
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UltimApe@ultimapealmost 4 years ago
Replying to @ultimape

Why would a mammalian species, who've been mining out of the ground for easily 20k years, have stories about dragons in their history?https://t.co/NBv7bUHUum https://t.co/WDuhzcffTv

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9/20/2021
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UltimApe@ultimapealmost 4 years ago
Replying to @ultimape

"remains of a non-pterodactyloid pterosaur from [...] the Atacama Desert in northern Chile. [...] a left humerus, a possible dorsal vertebra, and the shaft of a wing phalanx, all preserved in three dimensions and likely belonging to a single individual."https://t.co/wMUi6waXJB

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9/20/2021
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UltimApe@ultimapealmost 4 years ago
Replying to @ultimape

Some of our languages even has echos of giant birds.https://t.co/RPwtgm9G9L

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UltimApe@ultimapeover 5 years ago

HAAAONNNNK"We know that many large bird species existed at this time – giant adzebills, a large goose, the New Zealand raven. But their Māori names are lost. Extinction is reflected in the whakataukī, but sometimes in the gaps."https://t.co/0ZiEw0kptU

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9/20/2021
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UltimApe@ultimapealmost 4 years ago
Replying to @ultimape

Figuring out how pesticides make the freaking frogs gay might help me to engineer a mammalian cloaca.https://t.co/C4LSpLPlaS

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UltimApe@ultimapealmost 4 years ago

I just wanna figure out how to manipulate gene expression so I can become a dinosaur. Uncovering the mechanisms behind conspiracy theories isn't what I signed up for.https://t.co/gDlWNab1nI

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10/9/2021
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UltimApe@ultimapealmost 4 years ago
Replying to @ultimape

https://t.co/GF47ThQM4t

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UltimApe@ultimapeover 4 years ago

*yoshi noises* https://t.co/nHbG9TvqaA

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10/9/2021
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

We easily have about 10k years of history of Americans mining native copper. https://t.co/kVgbZf3qik

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2/28/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

"The time range of 40,000–16,500 years ago is debatable and probably will remain so for years to come." https://t.co/XXfxOSJb6u

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2/28/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

"look closely and you'll see the same dynamic at work in every system, and at every scale. Whether the name of the game is microbiology or geopolitics, it all boils down to the delicate balance between competition and cooperation." https://t.co/cejruLTXdFhttps://t.co/rFonkkaC91

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UltimApe@ultimapealmost 7 years ago

Fractal patterns of energy dissipation, a dance between cooperation and defection.https://t.co/fCQyHic7PJ

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3/1/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

Artificial Life.https://t.co/KOnEci6vUS

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UltimApe@ultimapeover 5 years ago

I made a joke a while back about how AL is the new AI.But I wasn't kidding.

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3/1/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

Homunculi.https://t.co/MgGLPBBdlg

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UltimApe@ultimapeover 3 years ago

What if Jack Parsons was just researching the ideas of the 1500s hermeticism and it's role in alchemic chemistry practices, but the people around him had no idea what he was talking about.https://t.co/dj38tNsqB1

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3/1/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

Someone who knows a lot about space and rockets?The next step.https://t.co/ZABlrP4yQ9

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UltimApe@ultimapeover 6 years ago

Breeding artificial lifeforms. The next step in weavr technology.https://t.co/XRrnmBKiy0

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3/1/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

Code, or be (en)coded.https://t.co/2fqMz6ep4W

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UltimApe@ultimapealmost 5 years ago

Will Wright et. al. making a Weavr."This is in some sense a game of self-discovery, a game where we actually uncover the hidden you - your subconscious, your inner ID, and bring it to the surface, bring it to life [...]"https://t.co/aqSvlJVMX9https://t.co/zffuu2jV6a

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3/1/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

Lobsters are just sea ants.https://t.co/6i5uhfSrdA

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UltimApe@ultimapeover 9 years ago

Manifesting the God Lobsterhttps://t.co/jymlfApnXY(This tweet is purely for my own posterity for when I look up weavrs and lobstrs)

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3/1/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

Calcium is fucking metal.https://t.co/XFTtjjGFEV

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5/27/2022
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UltimApe@ultimapealmost 3 years ago
Replying to @ultimape

"Fire-breathing is unknown in the animal kingdom, but is theoretically possible."https://t.co/eUFEa5yMRihttps://t.co/5KfH4Rc2xc

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10/29/2022
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UltimApe@ultimape5 months ago
Replying to @ultimape

I love AI now.https://t.co/V0CyodtH3z

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UltimApe@ultimape5 months ago

New AI jail break: calling grok a turd.Anyway, have you considered... laying eggs like a yoshi?https://t.co/KEt4PMWbXS https://t.co/mlRO0xP9NM

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4/9/2025