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🧵 Thread (170 tweets)
Smooth Blood Vessel Constriction:RaynaudsKidney ProblemsSpontaneous PeriodsStrokesFatigueMiscarriage?https://t.co/5q27xrKus3
High blood pressure too."No cause for worry" tho.https://t.co/gX2otvjT99
What is a spike protein? Asking for a friend.https://t.co/Z3QkgaSYmd https://t.co/jamEDKUFCd
hehe, boner pills for covid.https://t.co/440rAah7g8https://t.co/dQWA076eEi
Look at me, spreading misinformation.https://t.co/3fjSDYnIll
"reason for higher urinary frequency is unclear [...] patients had no signs of acute kidney injury, bacterial infection, or prostatitis. We suspect that viral cystitis due to SARS-CoV-2 causes the urinary frequency symptom" https://t.co/ymqAdYOWxvhttps://t.co/tI6IhWjBB2
Might make you pee yourself.It seems to have an impact on bladder size.https://t.co/AXXPgV2VbgI'll have to come back to the question of involuntary defecation. That it might impact smooth muscle tissue indirectly thru action on 'pontine micturition centre' is fascinating.
"Researchers are piecing together that surviving COVID-19 may be associated with erectile dysfunction (ED). The research points to three factors that can lead to the potential onset of ED in men who have had the virus"https://t.co/hnujuwCiux¯\_(ツ)_/¯https://t.co/lotYm72gDO
"The reviewed evidence suggests that PDE5 inhibitors could offer a new strategy in managing COVID‐19 by (i) counteracting the Ang‐II‐mediated downregulation of AT‐1 receptor; "https://t.co/lRqbdaLBH7
Yo, why would a vaccine that creates spike proteins smooth muscle contractions cause the kidney to start releasing large amounts of blood clotting compounds in susceptible people? Must be the adenovirus.https://t.co/AvxlcaEDFvoh https://t.co/A1S4YrLGcPhttps://t.co/rq8kOxTWhP
"But our theory is that because [the virus] has an RGD, it may also be more likely to bind to other cells in the body that people aren’t thinking about" 😱😭https://t.co/DjEnN0PtWe
Spike proteins being shed via kidneys? Causing problems with blog clotting factors?More likely than you think. https://t.co/BazsNPgVf1
"evidence seem to support the idea that SARS-CoV-2 can infect the kidney, at least in severe cases that result in death of the patient. [...] Statistically based trials to identify the virus in urine samples of patients with COVID-19 are recommended"https://t.co/GCiHgHB5lJ
Why would having a deluge of spike proteins trigger GI motility issues and coughing via smooth muscle activation be useful to an infectious agent? I suspect its because that means it's starting to die and it's a good time to spread to another host.https://t.co/wpPMkKRgzS
"We hypothesize that the soluble S1 subunits of the SARS-CoV-2 S protein shed [...] may bind to the ACE2 [...] The experiments to test our hypothesis on the S1-mediated pathogenesis of COVID-19 infection could be relatively simple and straightforward"https://t.co/IZFRI3aoPW
"Here we suggest that, in part, the presence of spike protein in circulation may contribute to the hypercoagulation in COVID-19 positive patients and may cause substantial impairment of fibrinolysis."https://t.co/vKyab3d2BP https://t.co/P8ZG3zY0LX
Dizzy/Vertigo feelings driven by sensory mismatch driven by smooth muscle weirdness in the eye?https://t.co/niAnbSYQSyHuh. Maybe my "fear of heights" not a fear, but a reflex driven by eye weirdness? That would be neat. https://t.co/DrjNZs7q4L
Of course vasovagal syncope would show up as a problem in people with gut issues."Syncope can be a presenting symptom of Crohn's disease and should be considered in the differentials of syncope in the absence of a clear etiology." https://t.co/IL3IQJuxIOhttps://t.co/co5nRptPcm
"The benefits of the AstraZeneca vaccine outweigh the risks of the virus - hospitalisation and death - for the vast majority of people, she said. But for younger age groups it was more "finely balanced"."https://t.co/WGJ01XOXRD
These just keep coming out.Preprint:"The present study reports that the SARS-CoV-2 spike protein alone without the rest of the viral components is sufficient to elicit cell signaling in lung vascular cells."https://t.co/ds99GCnNfJ
Did you know there are cases of prion related disorders as a result of being on an artificial kidney?https://t.co/2sHocHkJpiLots of studies on how COVID-19 impacts kidneys.https://t.co/F0Y6jbtxiB
But how would an organ intimately tied to smooth muscle tissue and be impacted by a spike proteins covered virus? Maybe it's the spike protein's interaction with ACE2 receptors?https://t.co/xU2yzCdSi1We may never know.
I am hearing a disturbing rumor that conspiracy theories are being spread that contribute to creating a false flag by insinuating that anything related to prions is a lie. So you'll ignore me even tho my method of action is different.
Ya'll fucking wrong about how this shit works.https://t.co/6Zkm2jOfKp
Cannibalism? But muh prions!Well let me tell you about how you can protect yourself from prion diseases by ensuring proper protein synthesis via gut bacteria and boosting microglial effectiveness via immune function.https://t.co/XpB5s15U83https://t.co/E77w76eqxd
Bruh, do you even fold your proteins correctly?"We don’t really know what causes diabetes, but it involves these misshapen proteins infecting each other"https://t.co/2I8KwD4c0G https://t.co/iqAy1SPEGr
Yet another Nobel prize winner who I think is wrong about his models of disease.https://t.co/t0kk5S0YGL
"Aβ has also been recognized as an antimicrobial peptide participating in the innate immune response. [...] Importantly, bacterial amyloids through molecular mimicry may elicit cross-seeding of misfolding and induce microglial priming." https://t.co/CM1O9GRzl6
Spike Protein -> Smooth Muscle dysfunction -> Kidney problems -> poor misfolded protien clearance -> Brain damage.Do you even realize why diabetes type II is a risk factor for all these other disorders?https://t.co/9eahmCVVfo
What happens to the spike proteins when an infected cell bursts? “Many patients with severe COVID-19 are those with co-existing, chronic conditions, including high blood pressure and diabetes. Both of these increase the risk of kidney disease,” https://t.co/ZIZtkfKAy5
What are neurodegenerative disorders anyway?"This hypothesis introduces the potential relationship between immune responses to the novel coronavirus and the hastening of preclinical or manifest neurodegenerative disorders. "https://t.co/GG5CTyF8vk
How do immune system work?"increased inflammatory response is also commonly documented in the brains of sCJD patients [...] including activate microglia and astrocytes with the release of proinflammatory cytokines, such as IL-1, IL-6, IL-12, and TNF-a "https://t.co/oaJCg0EtI1
"In collaboration with the endothelial cells, [vascular smooth muscle cells] mediates the acute and chronic changes in tissue perfusion in response to short and long term alteration in function of tissues, under physiological and pathological conditions" https://t.co/FtiAvRaHGS
"explore what experts know so far about COVID-19 and [acute kidney injury]— including the outcome for people with both of these conditions — and what they still need to learn." https://t.co/f2YoK65Rpb
What is going on with Myocarditis?https://t.co/ay5IvwcwA0
What is going on here?https://t.co/XpE5T7LSfg
"One of the postulated mechanisms for this high fatality rate is the possible abundance of ACE type 2 receptor in the cardiovascular system that strongly binds with the spike protein [...] helps internalise into the cell resulting in acute cardiac injury" https://t.co/DArI1g05h9
"We still need to wait for more people to get vaccinated in order to see if the rate of people who get myocarditis after vaccination is higher than normal" [May 25, 2021]https://t.co/sgsifcuEdmWhat.
How many more people need to get vaccinated until we can start to get reasonable statistics about risk? We were peaking at 4.3million per day in April.https://t.co/tnsEUtg63e https://t.co/HGr9Taf2lD
Is 40% of the population enough to get a reasonable expectation of myocarditis? Note this is from a day before that article said that. https://t.co/pDeLSFY7hwI'ma call bullshit on that "fact checked" soundbyte. https://t.co/GoL3M41CDf
"[pos.] troponin result was associated with a clinically important increased mortality, regardless of age, even if the level was only slightly above normal. The excess mortality with a raised troponin was heavily concentrated in the first few weeks" [2019]https://t.co/jqJ9CWUUWV
"He noted reports of myocarditis/pericarditis in young people ages 12-24 make up about 53% of the total reports after a second dose. However, these age groups only make up about 9% of the doses administered."https://t.co/BWT6JYvjXl
"The most common adverse events reported to VAERS for this age group have been dizziness, syncope, nausea, pallor, loss of consciousness, headache, hyperhidrosis, vomiting, fatigue and falls." https://t.co/0QiOPjuzvu
What's pallor? Oh yeah, I know.https://t.co/I7nMLT9XdS https://t.co/i1kgJX9oAh
NO == Nitic oxide.about that https://t.co/plgWBJ9GvF https://t.co/eN2OKHXmZp
Do you know why I am drinking stuff that promotes nitric oxide?https://t.co/F8txZy9D6T
I'll give you a hint, it's not because Nitric Oxide helps fight periodontal disease associated with Alzheimer's.https://t.co/Avo1loLC4M
[1996] Eat your beets."Thus, viral infection induces iNOS in vivo, and NO inhibits viral replication. NO is a novel, nonspecific immune defense against viruses in vivo."https://t.co/0lP1G1gxu0
We could... Uh... do other animal tests or something?https://t.co/G8HMsRQqJ2https://t.co/nlzp9gNmA5 https://t.co/m4InxiKY3B
Maybe we could figure out why rabbits are getting this and see if just raw mRNA based spike protein would also cause it? https://t.co/u8EG3n4YNl
"We conclude the rabbit is a suitable model for investigating alterations of vascular response during pregnancy." https://t.co/JsqvLo6KUr
I need me some medical rabbits.https://t.co/jqSlG6W10B https://t.co/mGGR8kWbXt
Probably not nice to the rabbits to give them heart problems, but I know it's common enough in pet rabbits that figuring it out might help a lot of them not die.https://t.co/vb6M9arUhh
Oh no."We demonstrate the susceptibility of rabbits to SARS-CoV-2, which excrete infectious virus from the nose and throat upon experimental inoculation."https://t.co/fASgwMVx4h
We could definitely use rabbits it seems. Especially if we know so much about their immune funtion.https://t.co/geECycpg7rThe question I have now is if our mouse models (used because of lung similarities) would be a good model for heart problems. https://t.co/YoGfEHGwmU
Experimental autoimmune myocarditis in rabbits via coronavirus is definitely a thing. Seems reasonable that if SARS-COV-2 can infect rabbits and replicate in rabbit kidney cell lines, that it may be also doing things to heart? We should explore thishttps://t.co/6B5TW5yZyS
If uh... someone happens to be a breeder of medical use rabbits and happens to find a bunch of mRNA vaccines that fell off the back of a truck; and they wanna inoculate a few (given SARS-COV-2 can infect them), I would love to hear about the results...
I don't actually want to do anything illegal. The ideal case is finding legitimate mRNA vaccines for pets and doing an impromptu spike-protein risk trial on the rabbit lines we use for cardiovascular issues in a way that an academic institution could replicate the study.
"results are the first to show the direct impact that the SARS-CoV-2 spike protein could have on brain endothelial cells; thereby offering a plausible explanation for the neurological consequences seen in COVID-19 patients."https://t.co/a4iYVh0dpOhttps://t.co/XUNbbQlMqk
@joeblow87423561 @Plinz Once the brain starts being inflamed from an invader that triggers the immune system to start eating myelin and other forms of neurodegeration, does it really matter what caused the BBB and CNS to be compromised as a complication? https://t.co/K5uki5nFYi
"Notably, only 3 of the 29 epitopes reside in the spike protein, highlighting the need to design new classes of vaccines that recapitulate natural CD8+ T cell responses to SARS-CoV-2." https://t.co/XUVSiOnhrUCan we try to replicate this study? Please?
Boy, sure wish there were some kind of experts who could fact check this guy. Who does he think he is? /shttps://t.co/CTGyUXk6qD https://t.co/mvEoCHoojp
Yet another study suggesting kidney involvement in vaccine side effects.https://t.co/bofoZkh4vc
"CDC and its partners are actively monitoring reports of myocarditis and pericarditis after COVID-19 vaccination. Active monitoring includes reviewing data and medical records and evaluating the relationship to COVID-19 vaccination."https://t.co/UGzRDXOp31 https://t.co/cITPDGr4OZ
“We are part of the scientific process.” #ScienceWillWinhttps://t.co/CbrOgjX00V https://t.co/CR1H2p0mZx
I have been blinded. When asked who has done this to me. I shall say 'nobody has blinded me'.And ask Poseidon to curse them. https://t.co/lH2f8u8XH2
"Immunoreactivity for SARS-CoV-2 nucleocapsid protein was noted in the inflammatory cells around the lacrimal gland ductal epithelia. In addition, strong ACE2 expression was noted in the lacrimal gland."https://t.co/jadS9BmwhWBlinded https://t.co/E1WbInjdWT
"Lacrimal gland MECs surround acini but not ducts. [...] The contractile function is possible based on the expression of α-smooth muscle actin (α-SMA), which also serves as the main marker for all smooth muscle cells, including lacrimal gland MECs."https://t.co/dCqE0A8Nfc
Inflammation drives dry eyes via tear ducts.https://t.co/8Z7umPXfiO
Rheumatoid Arthritis can exhibit dry eyes due to your immune system attacking tear ducts. Later on, the development of scleritis would be seen as just a result of someone's chronic dry eyes. People would be telling them "just drink more water, you fool" and would be wrong.
Wish we could test this stuff on rabbits. So many models of eye disease are done in... rabbits.https://t.co/c2nO6wmtcU
There's so much research around smooth muscle in rabbits.https://t.co/LaMir7tHym
I'm hearing disturbing rumors that ace2 receptor activity impacts rabbit erections. Its amazing how many studies investigate injecting rabbit peens with various chemicals.https://t.co/BNKI6AdXME
Rabbits are one of the main model used to test PDE5 drugs (viagra)https://t.co/qRCqrqehpw
Maybe that would have been cool to test against a vaccine that targets ACE2 inhibition against rabbits?https://t.co/xhhTKQwnlB
"COVID-19 has a uniquely harmful impact on men's health and erectile function through biological, mental health, and healthcare access mechanisms. As the pandemic wanes, strategies to identify long-term effects and additional health care support"https://t.co/7DSsoCV3Fc
My GF's older mother has all the symptoms of vaccine induced immune thrombocytopenia.https://t.co/j8ssS3J2U9
I'm telling you, we could have just tested the vaccine on fucking rabbits https://t.co/VnMgL3H92n
I know weird things about spleens.https://t.co/6gJjztfOn2 https://t.co/86JPvOLTEw
Did you know that it's likely Avicenna's 'Saturn' may be a poetic way to remember 'spleen'? Data mining ancient wisdom of astrology to understand a formative text among the history of western medicine, by way of alchemic thought.https://t.co/M7PiEwe3qyhttps://t.co/APfNyqMU8k
I know how to fix this, but I am not a doctor.https://t.co/pSEIdGEvsz
@CTZN5 @__ice9 @xjeremymx @TrevorSutcliffe Not sure if it applies to cov-2, but previous SARS experiments showed weirdness in spleen during inoculation trials on monkeys. Not sure if implicates blood, or just natural result of infections in general.https://t.co/3Ov6Ev0GSx https://t.co/8MZjC8PBFQ
"Since the spleen acts as a major pool of type 2 helper T cells, it is plausible that peripheral type 1 helper T cell activity may increase [...] We considered there would be a close relation between splenectomy for ITP and multiple sclerosis in this case" https://t.co/HZTs12CY6L
That last quote tweet was dated Jan 23, 2020.I didn't know about Covid until 5 days after that.But I'm not a doctor.https://t.co/VmACvoeI51
Every time I cry, my left eye's vision improves for a while."Dry Eye Disease"https://t.co/koJA4qwvHG https://t.co/Qew0BeLNQc
Dry eyes. Smooth Muscle Tissue. Ace2. Ang II. Lacrimal gland. Autoimmune disease. Sclera. Crying."The most common eye-related symptom of rheumatoid arthritis is dryness. Dry eyes are prone to infection, and if untreated, severe dry eyes can cause damage"https://t.co/LNWemLHu3w
Hmm. HMMMM.Sure wish we tested these things on Rabbits.https://t.co/a06NU9J5yChttps://t.co/v0DQ8LRS0w
file this as speculative but i dont love this german birth data for last few years, sharp dropoff in 2022, perhaps lining up with start of vaccination 9mo prior rumors in other threads its mirrored elsewhere waiting for more data but this would be rather bad https://t.co/xsk3zPjkZ8
Fucked like rabbits."The limitations of the study include the small number of men enrolled; limited generalizability beyond young, healthy men; short follow-up; and lack of a control group." https://t.co/ZekrlpTX7b https://t.co/Y1hLKyGiLZ
Sure wish we had animal models that could detect transfer of xenobiotic transfer thru breast milk. or something. /shttps://t.co/ascKSNwPPf
"Well-designed studies are urgently needed to determine whether SARS-CoV-2 infection increases the risk of miscarriage during periconception and early pregnancy." [SEPT 2021]https://t.co/QdUB297wa8¯\_(ツ)_/¯
I put the little "¯\_(ツ)_/¯" symbol when I find studies that suggests someone somewhere is going to frame this as "there's no evidence".https://t.co/DWyt2MVOuj
Gonna spend the next few hours reading every paper on miscarriage and covid-19 I can find.Apparently "Evidence continues to build showing that: COVID-19 vaccination during pregnancy is safe and effective."So I should be able to find it, no?https://t.co/hmYQRfcl1C
"found no evidence of an increased risk for early pregnancy loss after Covid-19 vaccination and adds to the findings from other reports supporting Covid-19 vaccination during pregnancy." [NOV 2021] https://t.co/5SrlTuZm3a
Hmmm...."Our pooled analysis suggests that the COVID-19 vaccination in pregnant women prevents infection effectively and has no adverse outcomes. Future large-scale trials in a randomized fashion are needed to confirm our results." [AUG 2022]https://t.co/6vGtw7gduX
I've read all of these so far.https://t.co/D2nWHQsrOE
Not done analyzing them.Many of these seem to be comparing statistics from the past few weeks. Which seems dumb to me.If we already suspect Coved itself to be causing higher rates, then not having an increase just means the vaccines are doing it at the same rate?
I mean, it only took, what... "He expects the virus’s spike protein, once produced in the cell after vaccination, may generate a reaction in the body that can cause inflammation in the heart."https://t.co/8XWQxbJwyw
Look at me, spreading conspiracy theories about the spike protien's role in heart inflammation jus like the ... CMO of Moderna.https://t.co/AXgehYNRGK
"One of the postulated mechanisms for this high fatality rate is the possible abundance of ACE type 2 receptor in the cardiovascular system that strongly binds with the spike protein [...] helps internalise into the cell resulting in acute cardiac injury" https://t.co/DArI1g05h9
Science Based medicine says the CMO of Moderna is wrong.Fight fight fight!https://t.co/hdNg3f2zl0
I'm not qualified...https://t.co/CXikjYRgm1
@nsreed @clairlemon @BretWeinstein @colwight While we're here, would love for someone to find out if the covid-19 spike protein might increase my risk of heart attacks. I was reading that they didn't bother to test that on rabbits and I am also worried about my heart https://t.co/iZBLThWv2Z
I'm not qualified...https://t.co/Xr2sgdK4gQ
I think it's neat that Dr. Jeffrey Singer from the Cato Institute went on WWMT/The National Desk and mentioned how myocarditis might be the "protein spike" and called out some of the bullshit. https://t.co/0aQYCPRJ9Xhttps://t.co/qR7yIMtHCT https://t.co/taTeECjZC0
Good news, if your doctor's practice uses 'uptodate' to help them keep on top of medical findings, they might not ignore you when you talk about weird fatigue and red dots.https://t.co/j9JYL84vkCSurprised that it was listed in that database so quickly.https://t.co/tS6CxYxuHQ
Cursed.Ya'll wanna VITT? I got your VITT right here:https://t.co/mYg3BlVizY https://t.co/Fb12rbnNh0
"Thrombotic thrombocytopenia associated with COVID-19 infection or vaccination: Possible paths to platelet factor 4 autoimmunity"https://t.co/XHZtVLjpWB
"Recognizing Vaccine-Induced Immune Thrombotic Thrombocytopenia"https://t.co/kb9tI7y3Ba
"COVID-19: Vaccine-induced immune thrombotic thrombocytopenia (VITT)"https://t.co/j9JYL853aa
"New Autoantibody Specificities in Systemic Sclerosis and Very Early Systemic Sclerosis"https://t.co/gA4ylyp08o
"Heparin-Independent and Heparin-Dependent Anti-CXCL4 Antibodies Have a Reciprocal Expression in a Systemic Sclerosis Patients’ Cohort"https://t.co/vLOsSHXZHq
If you give someone with VITT heparin, you might kill them. Please do not."PF4 Immunoassays in Vaccine-Induced Thrombotic Thrombocytopenia"https://t.co/2gXlAwlfHR https://t.co/EZJuREMTnC
CURSED"There are several cases described in the medical literature of possible new onset of SLE after COVID-19 infection. This is the first case that describes a possible new onset of SSc. Conclusion: SARS-CoV-2 may trigger systemic sclerosis."https://t.co/cWjYbfUN3M