🧵 View Thread
🧵 Thread (48 tweets)
This makes me giggle.Hey, @jessekarmazinmd did you see this? https://t.co/Go6IMJRdQk
I think that makes this the second healthcare venture that I've predicted was bullshit and based on false premise.Anybody know if Thiel Capital are investing in firm doing FMT? I wanna go for the hat-trick.https://t.co/tgs5ioeXP7
All these fad companies being funded because they can leverage wellness branding. No one wants to fund me doing research on electroshock butt-plugs to cure aging via reactal vagal nerve stimulation.https://t.co/iDDWlM2LQj
"Seed" develops a trusted brand while navigating oncoming storm of regulatory capture. Eventually gets bought by Coca-Cola/PepsiCo. Then the formula changes underneath them and it becomes just another probiotic branded juice drink SKU. It got Sugar; what microbes crave.
Will stick hotsauce up my butt for science.https://t.co/61LH18vasX
Small chance I might move to Canada to study psilosybin's impact on autism.I really am following in @tferriss's footsteps. :Phttps://t.co/IjoizK2e6c
While the news media is jerking off over the Theil Foundation being vampires. I'm actually exploring the history of Pellagra and serotonin deficiency's impact on aggression and possibly the desire to eat blood thru impacts on iron.https://t.co/fYq4m91PZ9
I wonder how much of this is true: https://t.co/08TjWQZ9nqA ward against curses? Vampires sucking breath from children? A ritualistic rumor & applied metis for spreading protective medicines from before germ theory of disease, but rife with folklore and mythos?Become witcher. https://t.co/7Y03VhJ6wt
Why did we call it cannibalism when we could just call it "unplanned spontaneous bacterial autophagy via reduction in serotonin processing in the intestinal microbiome" https://t.co/yQryu8KTLa
"You’re talking over 2,000 years. Cannibalism, to these writers, was the worst taboo. Add that to Christianity and Judaism where it’s important to keep the body intact and you get the knee-jerk reaction to the very mention of the word we have right now."https://t.co/OlQZmgXrnn https://t.co/8aLTolmOxM
Just shot water out my nose.https://t.co/STgnKAV5es
Dancing like a mad man.https://t.co/j9g1j1k4bzhttps://t.co/wPc8Wh01Og
I'm trying to get an audience with Peter Theil, mostly to tell him how he's an idiot and a genius.And I hate that I know what levers to pull to make this happen. Unspoken, but implied;https://t.co/jPuNwHn9Ga
"Our results indicate that classic psychedelics may have therapeutic efficacy that is more persistent than that of ketamine, and also suggest that a subjective existential experience may not be necessary for therapeutic effects."https://t.co/rQ5Wz8co2J https://t.co/YkusEeHqxI
"The phenylalkylamine hallucinogens are selective 5-HT2 receptor agonists, whereas the indoleamines are relatively non-selective for serotonin (5-HT) receptors." https://t.co/Ryz9dymU0b
"[suggests] binding of the serotonin transporter is unlikely to be a primary antidepressant mechanism at routine antidepressant doses, as substances that facilitate antidepressant effects via serotonin transporter binding show 70% to 80% occupancy"https://t.co/yOsEMBbX0y
"A deeper understanding of the many mechanisms by which 5-HT signaling can be disrupted, alone and in concert, may contribute to an improved understanding of the etiologies and heterogeneous nature of [autism]" https://t.co/gdCt0UxmN0https://t.co/PFvQ2fIgCd
Ya'll ever wanna just do shrooms to see if it has a long term improvement on autism symptomology?https://t.co/SAbrMRwJhC
@steven_kotler There are also some interesting things with serotonin and hippocampal function & stress https://t.co/3xkwWQR3mRThat show up all the time in microbiome research: https://t.co/ecywDn68PZThat seem to be mirrored in meditationhttps://t.co/AtIPDEFwYD
"these previous findings have implied that the actions of hallucinogens such as psilocybin might be due to a mixture of actions on both excitatory (e.g., pyramidal) and inhibitory (e.g., GABA-ergic interneuronal) neuronal circuits"https://t.co/RxQdrcvvZChttps://t.co/KZ0utR2RWA
I'm probably going to move in with my mom so I can afford better food, lol.https://t.co/KFvUeCGtEg
@Brainclinics @elonmusk Check out John Elder Robison's experiences as described in "Switched On". It took multiple rounds before he was able to reinforce empathy pathways they were targeting, and it degraded over time.I've had luck with doing this via diet tailored toward emotion centers of the brain.
I don't say that lightly.https://t.co/t32tHb36ak
I have bad ideas, will travel.https://t.co/Ft8fEqr352
Down the road I hope to try and find the strain of L. Reuteri that are in @seedhealth - they seem to be ones derived from breast milk(?). There are some studies that suggest it helps fight Candida.I have no idea where to source, it sounds promising. https://t.co/nwYLmFnGIb
"In conclusion, topical application of capsaicin causes a small fiber neuropathy and is associated with a delay in healing of shallow, but not deep wounds. This novel human model may prove valuable in the study of wound healing in patients with neuropathy"https://t.co/IhABgaIKwr
Does being out in the sun reverse diabetic neuropathy in a way that is similar to capsaicin's action on TRPV1?If it works on Parkinsons... maybe?https://t.co/fXUDSVXNuE
Neat."Red to near-infrared LEDs have been shown to promote mitochondrial oxidative metabolism. In this study, LED irradiation improved nerve regeneration"https://t.co/AvKA50UECD
"Thus, oxidative modulation is a robust mechanism tuning TRPV1 activity via covalent modification of evolutionarily conserved cysteines and may play a role in pain sensing processes during inflammation, infection, or tissue injury."https://t.co/I2LaNk927b
Become salamander. https://t.co/4bJL4ctdPN
haha"And Lewis would like to make it clear that Founders Fund’s excitement about the latest addition to their portfolio has nothing to do with the nature of Privateer’s product. Nothing at all. Really."https://t.co/nSmnyRtfKghttps://t.co/Ecxh2zG04r
I don't have health insurance tho. It will apparently cost me twice as much as my total income to use Sativix if we go by this estimate for UK pricing.Looks like I'll be learning how to make my own THC distillate from self-grown plants.https://t.co/Kzt06VlJHS
I shit you not. A rejected a girl I met on ok cupid back in 2014 because I saw the writing on the wall with the cannabis market. This was before I even knew about using it medicinally for M.S. etc.https://t.co/fUrBRacN1m
"Here we present a modern view of the [endocannabinoid] system, and alterations of its main components in human patients and animal models relevant to [autism]." https://t.co/i1DaS4dLt3 https://t.co/L37eOjCwQ3
"In both adolescents and adults, rates of NSSI are highest among psychiatric populations, particularly people who report characteristics associated with emotional distress, such as negative emotionality, depression, anxiety, and emotion dysregulation."https://t.co/G91kd0pq5K
"These preliminary findings highlight the need for increased awareness and further research about non-suicidal self-injury within autism spectrum disorder."https://t.co/1YCtitsZJz
Populations of people with poor lipid regulation and impaired endocannabinoid function are more likely to self-medicate with drugs or bodily injury to avoid chronic immune system driven pain.Nah, must be the pot making them do it. 🤪https://t.co/bEoJNuWbf9
They called him the mountain called monkey.And he spit fire like a salamander."There were no screams, there was no timeThe mountain called Monkey had spokenThere was only fire, and then... nothing"🎶https://t.co/FpAuhFMEqXhttps://t.co/yMtjC5BmE3
"powerful predictor of [bed sores] as well as mortality and other poor outcomes. [...] is popularly perceived to be caused by malnutrition, acute and chronic illnesses often cause hypoalbuminemia, and acute illness may be the primary driver"https://t.co/jpGw3JX9lJ
Why would fixing albumin impact liver health? Maybe Bilirubin?"Bilirubin IXα is insoluble and binds to albumin in the blood for transport to the liver for conjugation"https://t.co/9GSnpuSb9M https://t.co/LCx5PQmcS2
Bilirubin being tied to liver via bile production is fascinating.https://t.co/eTUvfScWlR
I love that I can just type "albumin" into my twitter search and inevitably find something fascinating.Like a finding that nutrition levels + inflammation plasuably drive hypoalbuminemia. https://t.co/Z9n0VQCO7zhttps://t.co/xpzWxKRoBZ
Mangan also has some commentary on the Saline+Albimum study at the root of the thread.I figured this was about replacing old blood & poor liver/kideny function around that process. But poor metabolism of iron => (high free iron levels?) may be it too.https://t.co/N9GPPvYcvF
You ever wanna just remove some blood from circulation for a while and see what happens?https://t.co/NEwQ4XspqP
Low oxygen / high co2 states are correlated with a lot of mammalian hibernation/aestivation factors. And Hibernation has been show to do weird things to the blood via spleen engorgement, and impact immune system. Something weird here.https://t.co/hVenP6xE33
@nosilverv @__________ur0 @dvdhhhh Lots of stuff promoting blood donations talk about it a lot."effects of blood transfusion and blood donation on the immune system are still unclear. In a prospective study we investigated the effect [...] on several immunologic parameters." [1996]https://t.co/qOrnagHF8k
huh."The level of autophagy is considered as an indicator for monitoring the toxic impact of pesticide exposure. Avermectin (AVM), a widely used insecticide, has immunotoxic effects on the pigeon spleen." https://t.co/36tisfLQJZhttps://t.co/hjfsPdoLhk
The big sleep.When your blood cells go to the spleen and fight.https://t.co/C60ru5ub5J https://t.co/UivviMb74e
If your body make all the blood go into the spleen while hibernating, do you think they start eating each other as a sort of local/acute apoptosis effect?https://t.co/thooVGu1pE
Body temp correlates loosely with spleen engorgement. Fits more resent findings."During arousal bouts in small hibernating animals, there is a rapid (within a few hours) reappearance of retained lymphocytes probably from the gut and spleen to the blood "https://t.co/EAzs7PauvN
"Hibernating ground squirrels experience a similar loss of blood flow to the brain as ischemic stroke patients, but squirrels wake up without trauma because a cellular process called SUMOylation protects their brains."https://t.co/TL0i7LKWJp
