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🧵 Thread (274 tweets)

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UltimApe@ultimapealmost 6 years ago

Do you ever wonder if Pavlov's theories, aka classical conditioning were wrong about how it worked, and then go on to question the entire field of learning theory perhaps derived from plausibly false insights?Sneeze pup, sneeze.https://t.co/eTt9AGlYNU

22 3
10/21/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Achoo.https://t.co/LQDm1KYlFw

3 0
10/21/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Sorry. I can't think well. My nose is stuffy.https://t.co/9fX5xorziX

8 1
10/21/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

If our gut's Circadian Rhythm responds to food schedules, how would one measure if it is actually cue'ing off sensory experience is much the same way as how bees integrate sensory experience to figure out when to hibernate?https://t.co/YhZYkrRX6e

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UltimApe@ultimapeabout 6 years ago

@MarkProffitt "Barometric pressure accounts for an additional 2% of the variation in bee egress rate when added as a predictor variable alongside solar radiation and temperature"https://t.co/RcrIN5SvXaWhy does this exist is bees *AND* humans?

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10/21/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Wake up! Time to eat, vagus nerve says to my stomach.Wake up! Time to eat, stomach says to my vagus nerve.Quiet! If you don't calm down you're going to bed w/out any dinner, says my suprachiasmatic nuclei. My mouth begins watering. Fasting it is!https://t.co/w4jim8tFeR

5 1
10/21/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Wake up wake up! It's dark again! Yells my skin."a type of opsin known as neuropsin is expressed in the hair follicles of mice and synchronize the skin's circadian clock to the light-dark cycle, independent of the eyes or brain."https://t.co/hnZSyHZQHc

10 0
10/21/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Alas, I do not have the genes to produce cholesterol from plant fats, and lipid metabolism is weird. So my body's odd development of vitamin D means I can't tell the skin to calm down.https://t.co/NhSCKJfIMP

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10/21/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

This button won't work on me because the receptor in my eye and the neural pathway is mutated. I have to reset the other systems and hope they sync.https://t.co/qwXScJOj1V

3 0
10/21/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

The tail wags the yawning dog.The house's dog yawns when she sees me yawn, but not when she hears it. She's not deaf, but that sensory modality isn't synchronized with other parts of her behavior.How to make a dog yawn by smell?What is learning anyway?

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10/21/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Training my microbiome to do stupid human tricks, like respecting the clock and not complaining about 24 hour privilege.My nose don't work, so I can't ring bells in my head with scent.https://t.co/zzC2OAIYyM

4 0
10/21/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

You are now thinking about delicious coffee. The rich velvety texture as it rolls over your tongue. The warmth of the rich beans as they wash over your pallet. The feeling of swallowing as you hold your breath for a moment. Delicious.Learned helplessness.

2 0
10/21/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

What if everything you think you know about learned helplessness is wrong. What if the dogs microbes were killed from the stress, and the behavior we see is from lack of activation of dog's hippocampus to manage memory?Temporary catastrophic forgetting.https://t.co/PiFjKEtmME

4 0
10/21/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

How strange to see a rat that is more susceptible to depression symptoms also seems to have tie to the microbiome's regulation of the hippocampushttps://t.co/ytdNuPzkJZ

3 0
10/21/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Slapping myself in time with the annoying sound so that my skin triggers a stress response in my bones thru calprotectin.https://t.co/yWR7Jc0nsm

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UltimApe@ultimapealmost 8 years ago

IF you have trouble with acoustic habituation: you can use your body's Proprioception (sense of self), to can mitigate it a bit.

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10/21/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Slap yourself to wake up?https://t.co/9PZ22PkNU2

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10/21/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Slap your self to change your sleep habits thru mechanical stress to your body's sense of pressure and pain in the subdermal sensory array known as TRP patways.https://t.co/NXlSqW5Krj

2 0
10/21/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Slapping yourself to replicate the science of attention and the effect of drowsiness as see in the myth-busters.https://t.co/nwsLDVuTBX

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10/21/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

SOBER UPhttps://t.co/DXcmoPd2Rg

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10/21/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

I can't even imagine what coffee smells like when I try to describe it. This wasn't even on purpose!https://t.co/hP5KOffoia

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UltimApe@ultimapealmost 6 years ago

You are now thinking about delicious coffee. The rich velvety texture as it rolls over your tongue. The warmth of the rich beans as they wash over your pallet. The feeling of swallowing as you hold your breath for a moment. Delicious.Learned helplessness.

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2 0
10/21/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

"We conclude that endogenous opioids are critical to experiencing both positive and negative emotions in music, and that music uses the same reward pathways as food, drug and sexual pleasure."https://t.co/A8Pq1k5VqiMouth watering? Slapping? Kinky shit.

3 0
10/21/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

"Breathe the pressureCome play my game, I'll test yaPsychosomatic, addict, insaneBreathe the pressureCome play my game, I'll test ya"https://t.co/zAx0h250Ed

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10/21/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Mind you, I am not critiquing Behaviorstein, I'm critiquing his monster. Cross-field studies are full of misunderstandings due to trouble seeing within them."The misunderstanding of behaviorism is unfortunately far more pervasive than it should be."https://t.co/k3qHwVz9Wr

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10/21/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

What I'm trying to say is that Pavlovian and Skinnerian theories need to be understood in light of modern thinking on neural variation, population phylogenetics, and risk/reward tradeoffs in the context of microbial impacts on behavior.https://t.co/e2DlFPRMZo

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10/21/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Stop ignoring outliers on the canine condition.https://t.co/NcIuc0JMrA

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UltimApe@ultimapealmost 6 years ago

I literally found a science paper that just excluded a dog that was likely autistic. Wiping normal dog variation under the rug so that they could tie their narrative up with a nice ribbon. This effect, compounded over, 100s of years is why we are biased.https://t.co/8oN4GvetO6

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10/21/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Woke up and saw this."The microbiota-deficient mice were unable to update their response, and showed persistent fearful behaviour long after control animals had adapted."https://t.co/ashYppGqzKRight on schedule; my mouth watered in sync with my circadian rhythm.

7 1
10/24/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Quiet down you. I don't want to hear your weird theories about bone hurting juice being a major player in stress pathways.https://t.co/1akDZHFsJ0

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UltimApe@ultimapealmost 6 years ago

Pooh, that not Quercetin,That's anti-bone-hurting-juice....Taste like quiet.https://t.co/WZR13VStmC

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10/26/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Stress pathways modifiable via environment and biology?What's that?https://t.co/94EvwanJft

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UltimApe@ultimapeover 6 years ago

I also find all sorts of stuff on how having a big (IRL) social network means less stress and depression. But what if we've got that wrong - its that people who have high brain plasticity can reduce their negative think easier while also supporting more social parts of the brain?

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10/26/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Stuffs going to get real weird when we start getting microbial and dietary impacts involved in stress and sleep research.Despite 23andMe & genetic chronotype research, we're not even close to mapping the impacts of immune system on sleep.

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10/27/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

23andMe's studies/questionnaire on sleep chronotype doesn't even have the ability to answer for me because I'm non-24.😂As far as I can tell, the 3 meal-a-day 24-hour sleep schedules are largely an artifact of culture.https://t.co/WLas2S7M0B

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UltimApe@ultimapealmost 7 years ago

My demon is not a thing, but the lack thereof.The lack of time.Asynchronous.Forever puppeted by event driven systems of thought.Call and response like the beat of a drum.Time dripping thru my fingers, unable to grasp it.https://t.co/OS3qDbhZ71

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10/27/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Fat cells have a rhythmhttps://t.co/kKWsahJDzGAnd so do gut microbeshttps://t.co/Ua61a7lCWjAnd even our skin responds to stuff weirdly.https://t.co/raVarjWcxfI am losing track of time because of stress and cold.I want to know why.https://t.co/xJdUxqEkxD

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UltimApe@ultimapealmost 6 years ago

@aaronzlewis I'm aiming for personal time perception myself. I saw this and realized that she was using basically all the brain scanning tech I was looking for to measure emtions and flow states.https://t.co/nN8fCrZrcJSomething something @mindfulcyborgs

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10/27/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Slapping myself to wake up... So that I might keep pace with society.https://t.co/MOG1a9MOK4

2 0
10/27/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

The best part of waking up is Folger's in your cup, triggering a sensory cascade that activates saliva glands in response to food anticipation triggered by long term training of gut bacteria on the brain.https://t.co/V403RswWmV

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11/11/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

What if sensory experience of running water triggers smooth muscle tissue in the bladder because of a sensory processing associated anxiety reduction via a microbial.https://t.co/aUNAkV4o9G

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11/11/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

"The intestinal microbiota undergoes diurnal compositional and functional oscillations that affect metabolic homeostasis, but the mechanisms by which the rhythmic microbiota influences host circadian activity remain elusive."https://t.co/SVIFD7z2Xj

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11/11/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Serotonin signals thru the day seem to correlate with circadian rhythm. A different way to say that it correlates with food anticipation and the gut bacteria's own rhythms.Perhaps other endocannabinoids are doing the same sort of thing?https://t.co/IQiYCH1qVv

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UltimApe@ultimapealmost 6 years ago

Current status: convincing everyone that trying to hibernate is a good idea and not to put me in an asylum.https://t.co/Z1gjMvCb17

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11/11/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

"Although the cross talk between energy metabolism and the circadian system is well documented, little is known about a potential circadian modulation of human eCB activity." (h/t @be_canna)https://t.co/1cHkvfNstz

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11/11/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

"Blockade of the CB1 receptor in these mice results in decreased food intake, indicating that at least part of the anorexigenic effect of leptin is due to decreased [Endogenous cannabinoid signalling]."https://t.co/NXFaeip9ntThis Bears 🐻 repeatinghttps://t.co/DPvrIs5vhT

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UltimApe@ultimapeover 6 years ago

So, my crazy brain, you're telling me that Capsaicin must act similarly to prolactin?What happens if I look that up?"[Prolactin] sensitizes TRPV1 responses in sensory neurons"https://t.co/UUTu2UK90ahttps://t.co/b2cvirscxV

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11/11/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

This Bears 🐻 repeatinghttps://t.co/hOnT0rnuH2

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11/11/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

"George Miller was a humble man who never would have dreamed that his article would become so important, nor that the entertaining manner in which it was presented might discourage others from pursuing the basic phenomena described within."https://t.co/3RmhQ5dESx

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11/14/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Looking up alcohol's impact on short and long term memory. How CB1 & CB2 receptors + way the Cannabinoid system is impinged upon by the gut.https://t.co/Z0Fpy2SwIjDoes runner's high improve long term memory?Is Anandamide partly why walking improves cognition in adhd?

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11/14/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Mnemosynehttps://t.co/xPjP3nsGgg

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UltimApe@ultimapealmost 6 years ago

"Based on the findings, hippocampal atrophy “may contribute to the neuroprogressive nature of bipolar disorder,” particularly in those also affected by diabetes."https://t.co/mKDmlmEpwzI'm just bullshitting causal effects for biolar disorder now.https://t.co/VMaODMk1GV

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11/14/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Mnemosynehttps://t.co/7hDLUsbeQy

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UltimApe@ultimapealmost 6 years ago

Mental decal. Excess alcohol lowers hippocampal volume (amount, not signal strength).https://t.co/fF8QhAAu68https://t.co/P6IG8KZaey

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11/14/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

I can't remember where I put this.https://t.co/KvrGkbZiIE

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UltimApe@ultimapealmost 6 years ago

Going to start collecting articles talking about how the stuff they were researching to effect memory and recall "don't work" and haven't been proven by science. Because 90% of the time that 'science' is mouse models. and well...https://t.co/alaSg6iNED

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11/14/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

"from:ultimape decay"https://t.co/dXj4Q02umU

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UltimApe@ultimapealmost 6 years ago

As I drift in the indifferent blissand derangement of Multiple Sclerosis,I get glimpses of ideas, of pain.A memory of losing memory.Reminding of about loss,death, and decay.Facing my own mortality?It seems just reminds me of my friends going away.https://t.co/lhAljydW5G

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11/14/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Collapsing mind palaceshttps://t.co/oiVkAi8Ras

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UltimApe@ultimapealmost 6 years ago

@ctrlcreep Losing myself in the maze of ideas.Back filling the way I came to bury my daemons.Leaving them entombed until the ideas decay.The waste heap of my mind palaces.

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11/14/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Death cults, and wanting to resurrect ideas, like souls manifesting a body. Ideas like zombies, lurching on thru deep fried memes.https://t.co/hnmnzILTp3

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UltimApe@ultimapeover 6 years ago

Fixing the body, while the brain rots away.Fixing the brain, while the metabrain rots away.Fixing the metabrain while the planet rots away.Fixing the planet while the sun rots away.Decay is inevitable.

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11/14/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

maybe I spent memosyne wrong? Or is it brain rot?Nope. Twitter just fails me again."from:ultimape Mnemosyne" nets 2 results, neither of them are this tweet:https://t.co/VW4v0Swtdb

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UltimApe@ultimapealmost 7 years ago

Chronos & Hypnos walk into a bar, they see Mnemosyne there but can't remember when they saw her last. She tells them about how her daughters inherited her memory and use it to tell bedtime stories to teach children the way of the gods.https://t.co/2XiTF6AA80

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11/14/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

I found it by remembering that I wanted to save time in a bottle, like an external memory for causative non-linear reality.So... my idea must be encoded as keyword in my spotify playlist to remember time.Ah yes... Time is on my side.https://t.co/k0aOPvzcgx https://t.co/RjfyoDInEL

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UltimApe@ultimapeover 6 years ago

Time is on my side. 🎶https://t.co/3gKnyQgzH9

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11/14/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Why does mnemosyne keep popping into my head? Greek gods?Greek... Philosophers?Greek... Orators?Yes. https://t.co/dvcGBpCurhSo what does synesthesia do to working memory? https://t.co/ZTQ0S9m2e8

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11/14/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Fluoxetine? what are you doing there little buddy? https://t.co/WXRPzDsvoohttps://t.co/7IM0Sye4A7 https://t.co/gNFFn1XPuB

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UltimApe@ultimapealmost 6 years ago

Don't mind me, just trying to figure out how our gut microbiota may effect social behavior memories via what I suspect is chemically induced brain fog via Synaptic Plasticity ala Fluoxetine (Prozac).https://t.co/3zHkgJCx8Thttps://t.co/hRCIElKkdd

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11/14/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

"Herein lies the paradox. Humans have a superb sense of smell, they can detect ethyl mercaptan at exceedingly low concentrations, yet it takes 57,000 times threshold in order to spontaneously shift attention to olfaction. Why?"https://t.co/GXYEhUCkCg

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11/26/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

When my stomach and nose go, so does my voice.Why?https://t.co/zdwX28F0xV

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UltimApe@ultimapealmost 6 years ago

A witch gave me a tincture that allowed me to speak during one of my meltdowns.Mathew 9:33-35What are my demons? That which possesses me.Matthew 9:16-17; Mark 2:21-22; Luke 5:36-39Prebiotics and probiotics in biblical lore.

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11/26/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Isolated Caynenne clears up my noseIsolated Pinene makes it run, but just a bit.I'm thinking about the intestinal mucous barrier and the impact of THC on TRPV1 and interactions with Acetylcholinesterase inhibitors.https://t.co/So32yhUgsghttps://t.co/fN3bNEWlwT

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UltimApe@ultimapealmost 6 years ago

I'm going to shove a pinene suppository up my butt sometime in the next two months to see if it solves my crohn's and ameliorates runaway immune system cascade leadsing increased autism meltdowns by way of Multiple Sclerosis's impact on sensory processing.https://t.co/nQqoFFOkSW

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1 0
11/26/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Sneeze'ing the dog.https://t.co/sVSoihV19F

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UltimApe@ultimapealmost 6 years ago

Do you ever wonder if Pavlov's theories, aka classical conditioning were wrong about how it worked, and then go on to question the entire field of learning theory perhaps derived from plausibly false insights?Sneeze pup, sneeze.https://t.co/eTt9AGlYNU

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1 0
11/26/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Mucosal barriers help the intestines absorb nutrients just like the nose's mucus lining helps the scent'ing system differentially detect nutrients.https://t.co/5ToXAE3Oxv

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UltimApe@ultimapealmost 6 years ago

@gwern @The_Lagrangian The light organ itself develops in interplay with bacteria and impacts a large number of other parts of the organism. As far as I can tell, bacteria improve mucous function and that has a direct impact on smell to the extent that it in artificial noses: https://t.co/MoVrHAgE5W

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11/26/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

chemosensors all the way down.https://t.co/1ifbxIZ5vd

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UltimApe@ultimapeover 6 years ago

"stretching 20ft from mouth to anus, air and light at each end, an ingenious pipework that incorporated oesophagus, stomach, small intestine, ileum, colon and rectum, and contained 100m nerve cells or neurons, more than in the spinal cord, as well as 95% of the body’s serotonin."

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11/26/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Taste buds, in my duodendum? More likely than I want to think."This learning process for flavor preference consists on classic Pavlovian conditioning reflexes from the post-oral nutritional effects of foods"https://t.co/FYhGXTtatjhttps://t.co/xF3ObfK4lX

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UltimApe@ultimapealmost 6 years ago

Something smells funny.https://t.co/ZFIHfExWLF

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11/26/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Quanta Magazine has an article detailing advancements in fear extinction and learning as it relates to mice + microbes.https://t.co/IC8K0nerrWCites:https://t.co/eeTfyovHSqhttps://t.co/Nz4dCtU6S7https://t.co/Suhp3ySGCq https://t.co/U06JsyoExA

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UltimApe@ultimapealmost 6 years ago

Woke up and saw this."The microbiota-deficient mice were unable to update their response, and showed persistent fearful behaviour long after control animals had adapted."https://t.co/ashYppGqzKRight on schedule; my mouth watered in sync with my circadian rhythm.

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12/4/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Trying to figure out how to decondition myself from fear & anxiety.Everybody's doing this whole sensory acclimation thing using stimulus pairing and neurofeedback. But it was taking too long for me.So I ate some bacteria poop to enhance learning.https://t.co/ZRzOHRm9h8

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UltimApe@ultimapealmost 6 years ago

Control your fears, they said.It's all in your head, they said.You're problems are caused by your lack of will power they said.I said fuck that noise.https://t.co/U9KBooN1kL

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12/4/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Still trying to figure out how to decondition sound startle response in myself.https://t.co/vwvkoCKwjJ

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UltimApe@ultimapeover 8 years ago

Dishabituation and the Acoustic Startle Response.Wincing in pain at the growl of thunder.https://t.co/QszAcQei0z

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12/4/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

I can't find much on ideas on multi-modal sensory integration & fear except in a thesis"Individual Differences in Fear Conditioning: Influence of Compound Presentation of Stimuli and Reinforcement Rate" by Asif Dhanani ala Berkeley https://t.co/77xXU5xwa4https://t.co/Lm4KnRzsaS https://t.co/tpt8fE7lkO

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12/5/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Same"We are also interested in extending this work to developing a computational model of PTSD."https://t.co/2EL669uZdAhttps://t.co/pQrZ5NphKy

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UltimApe@ultimapeover 9 years ago

TL;DR: sensory processing disorder in autism: worst effects of PTSD for no damn reason. https://t.co/Ol7z4yWdyX https://t.co/ungy9sldO4

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12/5/2019
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

Due to an incident with pickled herring over the holidays. I have confirmed first hand that it's likely TRPV1 receptors in the lungs respond to acid & feel identical to the burning feeling of cayenne.Possibly related: https://t.co/9VvbTq1UJIhttps://t.co/xhAbRRJ6YL

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UltimApe@ultimapealmost 6 years ago

Sorry. I can't think well. My nose is stuffy.https://t.co/9fX5xorziX

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12/26/2019
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

In other news. I am building out an environmental sensor to particulate matter.There's some weird things in cognition studies that seem to be centered on particulate matter. Would be funny if all my research into TRP => endocannabinoids end up relevant.https://t.co/DSsTTEDFHO

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12/26/2019
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

If particulate matter (pollution) affects cognition via TRPV1 => Anandamide along similar pathways to why exercise (triggering anadamide) seems to improve thinking; then this weird association with 'noise' from traffic might actually be about smog?https://t.co/Zi78Ko6STz

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12/26/2019
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

I need a watch that periodically prompts me to test for reaction time.https://t.co/5BMsz24j7s

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UltimApe@ultimapealmost 6 years ago

I tried a cayenne tincture on my new friend's recommendation during one of my meltdowns and it gave me the ability to speak back! All my muscles relaxed, and while I was still in a hyper vigilant state, I wasn't trapped in my own head and my narrowing of vision reversed. Crying.

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12/26/2019
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

What's fascinating about this TRPV1 => Anandamide angle is that it suggest sensitive individuals (poor diet, genetic disposition for TRP associated nerve growth), and those subject to the highest concentrations of particulate matter would experience the IQ changing effects.

2 0
12/26/2019
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

There's an angle here on Environmental Justice.https://t.co/XqESK3FoJt

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12/26/2019
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

"We conclude that even non-hypoxemic patients with COPD show significant impairments in cognitive performance."https://t.co/qb2TgKmklk (n=50)

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12/26/2019
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

"Patients with [COPD] and [OSAS] show similar neurocognitive impairments. [...] with low blood oxygen levels in both syndromes, it seems that low blood oxygen pressure is the dominant factor [...] However, further research is needed"https://t.co/Xa3C0TA3sH

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12/26/2019
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

Note to self: set up an air filter renewal subscription.On Amazon Subscribe & Save.https://t.co/3wGcZ63IQa https://t.co/weeMaCEx7A

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12/26/2019
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

I have a bunch of DIY air filtering techniques compiled together. I want to get to the point of filtering out radioactive particles, but haven't gone deep enough to figure that out yet.Homeostatic Mechanisms > Initiatives: Air Filteringhttps://t.co/99cOusMWNW

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12/26/2019
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

There are some pretty strong ties between COPD and air pollution, which would tie air pollution to cognitive decline. It seems studies are the strongest within the space of fire cooking, but I can't imagine car exhaust is that much of a stretch.

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12/26/2019
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

The reason I bring up TRP pathways is because of how often temperature seems to affect these things.https://t.co/bEX4XYRJnAWhich is a direct link to the TRPA1 and TRPV1 aspects discussed in this other paper on lung issues.https://t.co/cEE7MSaivi

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UltimApe@ultimapeover 5 years ago

Due to an incident with pickled herring over the holidays. I have confirmed first hand that it's likely TRPV1 receptors in the lungs respond to acid & feel identical to the burning feeling of cayenne.Possibly related: https://t.co/9VvbTq1UJIhttps://t.co/xhAbRRJ6YL

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2 0
12/26/2019
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

Why does this matter to me?Both my mom and my dad have COPD. My dad stopped smoking 10+ years ago.My mom's COPD spontaneously went away, as well as spontaneous remission of emphysema. She still smokes.Why?https://t.co/kQbJ5w4kwm

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UltimApe@ultimapeabout 6 years ago

Louder, for those in back."It is unclear exactly how the gut bacteria is communicating with lung tissue to create this effect, and the next step for the researchers is to investigate this unexplained mechanism."https://t.co/cjzzLafV1u

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12/26/2019
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

What I don't understand is why/how Pinene is working to take away a persistent wheeze I have during the winter.https://t.co/FwR6WOugbq

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UltimApe@ultimapealmost 6 years ago

Isolated Caynenne clears up my noseIsolated Pinene makes it run, but just a bit.I'm thinking about the intestinal mucous barrier and the impact of THC on TRPV1 and interactions with Acetylcholinesterase inhibitors.https://t.co/So32yhUgsghttps://t.co/fN3bNEWlwT

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2 0
12/26/2019
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

https://t.co/9toThGWRgE

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UltimApe@ultimapeabout 6 years ago

bUt ThE lUnGs ArE sTeRiLe!

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1 0
12/26/2019
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

"You can smell the defense chemistry of a forest under attack. Something is being emitted and plants and animals perceive that and change their behaviors."https://t.co/r9IWeZVMoxPinene affects actylecholine by downregulating a thing that metabolizes it. Changes behavior.

5 1
12/27/2019
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

Pine trees are manipulating your microbes by changing how your body's vagus nerve senses them, and this seems to have large scale impacts on your immune function as a result.How does pinene expression change during winter?What does a dying Christmas tree smell like?

8 1
12/27/2019
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

🔍Research💊DrugsTerpenes & Terpenoids, and other plant derived chemicalshttps://t.co/LcFgd9ZNCt

4 0
12/27/2019
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

No idea what i'm talking about.https://t.co/o4bD8eUuKj

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UltimApe@ultimapealmost 6 years ago

Talk to me about terpenes and alkaloid function as it relates to bacterial signaling in the body.https://t.co/kiTZceIMRF

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1 0
12/27/2019
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

"We are proposing an oscillatory habituation mechanism of extinction that can integrate and reconcile some computational and behavior mechanisms in the unified model of Pavlovin conditioning"https://t.co/6ZJ7Q1JjYqSo... gut microbe growth/decay & population cycles, no?

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12/27/2019
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

Everything makes sense when you realize that homeostasis is actually part of a complex thermionic workcycle process that we call life, and is by it's nature a dissipative structure.https://t.co/zloKIMF2CS

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UltimApe@ultimapeabout 9 years ago

Life poops out more life thru a complex mechanical work cycles.https://t.co/GfmBWfXdyN https://t.co/SKzerhVryc

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12/27/2019
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

Going to have a lot of fun this year while trying to find out what triggers my acoustic habituation responses.I think it's a feedback loop between my immune system and responses to mosquito.What does mosquito saliva smell like?https://t.co/LXh0A8bzYk https://t.co/L9aK5kVBDh

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UltimApe@ultimapeover 5 years ago

What the fuck.What are the chances that the kind of sounds I'm extremely bothered by during meltdown states are also the same frequency spectrum of a female mosquitoes wing beats?https://t.co/iQCTqYdmz4That sound makes me want to leave. Instant panic. Heh,

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2/10/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

It seems α-pinene might operate partially via inhibition of NF-κB https://t.co/Yk4zIYigUh which puts it squarely within pineal gland (and immune) territory. https://t.co/PKpXXz4r75

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UltimApe@ultimapeover 5 years ago

"This coordinated shift of the source of melatonin driven by NF-κB is called the immune-pineal axis. Finally, we discuss how this concept might be relevant to a better understanding of pathological conditions with impaired melatonin rhythms "https://t.co/tsx44okWEH

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2 0
2/10/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

This is weirdhttps://t.co/BBHefK2i7S

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UltimApe@ultimapeover 8 years ago

Study linking the D4 dopamine receptor mutation with Acoustic Startle Response attenuation over time.https://t.co/gfMGnIgJU9

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2/10/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

in particular because I've already figured out my circadian rythim is more stress (+adrenaline?) and food driven. So this suggests the acoustic startle issue might be tied to melatonin weirdness?https://t.co/8WcEBydZaD

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UltimApe@ultimapeover 5 years ago

I don't know what this means, but it seems important and might be related to my non-24."Circadian-Related Heteromerization of Adrenergic and Dopamine D4 Receptors Modulates Melatonin Synthesis and Release in the Pineal Gland"https://t.co/49pkbif0GJ

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2/10/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

Time to learn how to detect 6-sulfatoxymelatonin in my pee.https://t.co/PFtSbyWwD8

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2/10/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

I'm trying to figure out how to engineer my skin to feed a colony of microbes that produce erythromycin and other anti-viral compounds to act as a barrier against disease.Don't need to wash your hands if your body's holobiont is naturally antiviral. 😇🤫https://t.co/1rvJi1yNwG

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3/26/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

Regulating my internal immune system to help my body produce the right compounds so that it can work on feeding skin microbes. I was doing this research for mosquitoes, but now I'm wondering if I can do more with it.https://t.co/fxAKfxCzmh

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UltimApe@ultimapeover 5 years ago

@selentelechia @gwern @eigenrobot I also saw Cat Thyme has been used to improve bile acid and I am looking at what might doing this:https://t.co/fylT9ltJxk

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1 0
3/26/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

Looking up infection rates due to cumshots on a whim.Didn't find much, but semen viruses are interestinghttps://t.co/pqZMRvYYCkhttps://t.co/aSoY4vWYVJhttps://t.co/bYBycu3DpJSeems there isn't a lot of research on vaginal microbes fighting viruses.https://t.co/axwI4BySp5

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UltimApe@ultimapeover 5 years ago

Everybody is telling me that hand sanitizer is bad and I thought about it for a while.Then someone said a derivative of "a cat is fine too" and I had ideas. Not all of them are appropriate.Long story short: I'm now reading up on spit's antiviral activity & oral microbiome. https://t.co/qBYPiSZgm9

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3/26/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

Someone building a contraceptive releases anti-viral compounds.https://t.co/cGvlbRfArVIt seems there might be some people who's vagina is naturally resistant to HIV infections?https://t.co/jiRVK5nxrdHIV+ semen seems to work against that process.https://t.co/U0SBV5BB34

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3/26/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

With some inferences about the role of gut associated microbes in the production and management of those peptides.https://t.co/dSlyp2aHwphttps://t.co/oU7PJ1i88h

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3/26/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

Alright so that suggests anti-viral properties are in part regulated by what the skin produces, but also a result of interactions with host's microbes.I wonder if any of them are promoted when you coat yourself with old piss.https://t.co/S6YQeAl377

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UltimApe@ultimapeover 5 years ago

Please, for the love of god, do not use toilet water to wash your dishes.But... if you leave the urine in the toilet for a while, it turns into ammonia and can be used to clean things.Roman engineering... not even once.https://t.co/InRH7CQ33d

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3/26/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

Oh, hey, does vaginal mucus having anti-viral properties explain why anal sex is so much riskier?https://t.co/C2O8UJkvwlBut if you can get Giardia from anal, why not via oral routes? Isn't that something you get from drinking water?

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3/26/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

"Our findings suggest that the reduction in the incidence of paediatric asthma observed in recent years might be an unexpected benefit of prudent antibiotic use during infancy, acting via preservation of the gut microbial community."https://t.co/rQxgNlk4mX

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3/26/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

I have to remind myself this daily:"no, you can't taste anything with your testicles"https://t.co/SwYHUpkFyR

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UltimApe@ultimapeover 5 years ago

"Receptors in the respiratory and gastrointestinal tracts might serve to trigger a reaction to expel a molecule that’s potentially a threat, like a toxin. [Have] also linked the receptors to issues as diverse as cardiovascular disease, asthma, and obesity" https://t.co/60Ylf4h2zA

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1 0
3/26/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

What if your skin can taste bitter? What would that 'feel' like?https://t.co/2RNrSaewDg

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3/26/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

Well actually..."In fact, the medieval tendency to see disease as sexual sin was not solely based on moral judgments – there were also strong medical elements."https://t.co/Y5SxzvgRyS😝But this is a narrative violation.https://t.co/NXUY4VtI91

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3/26/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

I mean, I'd love to get shit from an actual historian on the nature of disease from the middle age while i'm in the middle of learning arabic to double check rhyming slang theory from Avicenna's texts on medicine. Cunningham's Law and all that.https://t.co/uG7PK3BwlV

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UltimApe@ultimapeover 5 years ago

So... I'm just bullshiting my way thru historical medical literature by pretending Avicenna's poetry is a form of cockney rhyming slang based on old models of alchemical thought.https://t.co/ravTFOfu5Y

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3/26/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

You got sick from "sinning" -> you got gonorrhoea from fucking a prostitute at a brothel."Concerns about the sexual transmission of disease via prostitutes were often addressed in an entirely rational manner."

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3/26/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

Did you know there were medieval cults focused on castration?https://t.co/iaxdZszi3rThis makes sense when you consider that modern medicine has been doing wonders at preventing death from STDs.

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3/26/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

"[STIs] been considered a punishment by the gods since Mesopotamian times. And it wasn't always about slut-shaming. It was likely inspired by the fact that for most of history, STDs were considered impossible to treat and, in many cases, a death sentence."https://t.co/THrzF6m9re

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3/26/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

If you wanna shit on guardian's narrative, perhaps suggest the very desire to frame nature as a separate entity opposing us may be a symptom of the disease they're trying to cure. "Nature" as construct westerners use to distance ourselves from reality?https://t.co/NGwJa4hhL8

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3/26/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

A study just came out suggesting that you also get allergy symptoms as a learned response to an environment, but only if you sleep on it. https://t.co/pJRVxpMJU7"allergy has been linked with both depression and suicidal behavior." https://t.co/EwGuEDfdT3https://t.co/XJajMx2WZo

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UltimApe@ultimapealmost 8 years ago

My random references to "the aha moment" are directly reffering to failures in the hippocampus related to processing new memories.https://t.co/SRfBdF8KNH

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5/7/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

SSRIs are weird. They trigger itch and runny noses in allergy free patients.https://t.co/FLu084W8KPhttps://t.co/KvY5dCAeqhand can induce full body allergic responsehttps://t.co/6gyR8Ow8bvWhathttps://t.co/OD2CqMVn3p

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UltimApe@ultimapeover 6 years ago

TFW: Reading a science publication that suggests the efficacy of Talk Therapy is on par with taking SSRIs, and then realizing that I could just eat bacteria shit and cure my treatment resistant depression. https://t.co/jN5azdd0ep

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5/7/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

Pavlov's dogs watering not because of a bell, but because of a gustatory stimulation response triggering a serotonin induced microbial feed back loop that drives gut colony circadian rhythm.

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5/7/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

"The data suggest that measurement of stimulated parotid salivary flow is a reliable indicator of drug-induced oral dryness."https://t.co/1Orfmw4FhF

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5/7/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

Did you know that "melanin-concentrating hormone cells" have been shown to be a driver of hippocampus memory erasure in mice?Funny that... https://t.co/He4lYEuh13

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5/7/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

melanin-concentrating hormone plays a role in memory and learning.https://t.co/yEhECrJwlkMelanin-concentrating hormone play a role in gut inflammation associated with colitis / crohn's disease.https://t.co/EXeVdxulfVhttps://t.co/rUoCq85ezI

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UltimApe@ultimapeover 5 years ago

@JunkfoodCinema @enkiv2 When I am gassey and constipated it seems to manifest in an aphasia like syndrome that seems to happen with Multiple Sclerosis. That my brain weirdness and farts correlate gives me a lot of weird ideas about the way that gut bacteria and mental health work together.

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1 0
5/7/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

But why would there be any reason to expect a role of MCH in any of this?https://t.co/8xaUPuqDSY

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5/7/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

Marble Burying? What's that?https://t.co/hN82SWr5JNOh right, thats one of the ways they measure autism like behaviors in mice.https://t.co/BfEjHxOKY0

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5/7/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

Tangential, but related, is a prediction that if MCH impacts these behaviors, affects sleep, and mediates food intake, then we ought to expect endocannabinoids to do neat things there.They do.https://t.co/3LxDSkW5DR

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5/7/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

Right. Of course they do.https://t.co/KFFqPWlQHZStressing out dogs until they give up would boost FAAH and cause immune system changes associated with CB1 and CB2 in interesting ways. https://t.co/4S5FxcRCxhI bet this is anandamide exhaustion.https://t.co/Suhp3ySGCq

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UltimApe@ultimapealmost 6 years ago

Woke up and saw this."The microbiota-deficient mice were unable to update their response, and showed persistent fearful behaviour long after control animals had adapted."https://t.co/ashYppGqzKRight on schedule; my mouth watered in sync with my circadian rhythm.

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5/7/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

chronic stress different response from acute stress."rats, chronic, intermittent water-avoidance stress was associated with reciprocal changes in levels of 2-AG and anandamide (increased) and endocannabinoid degradation enzymes COX2 and FAAH (decreased)"https://t.co/kM3jHl37xI

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5/7/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

This talks about hibernation as an evolved psychological response, framing it about observations in crickets, and in dogs.https://t.co/M7bARicP8vI think both of these effects are driven by immune->gut microbe shifts and the focus on brain psychology is incomplete/red-herring.

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5/8/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

I read most of studies that Dawkins was quoting about with regards to cricket biologic responses. IIRC it's the same rough cannon that Peterson is quoting when he talks about lobster hierarchies. I disagree with framing for reasons.https://t.co/6b1CjuwAsshttps://t.co/QXc9KVzZVO

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UltimApe@ultimapeover 8 years ago

The one on the right had a bad case of memes.https://t.co/NXj7VYMeeY https://t.co/VJsBFqLyms

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5/8/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

There's a bunch of studies exploring aggression & bullying behavior in lab mice. People go as far as to trace it to dopamine+ testosterone (with ties to fear/scent via T Gondii), but neglect to explore dopamine in the gut, nor Testosterone's impact on the mice's immune system.

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5/8/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

Anti-bone hurting juice."These findings provide support for a role of serotonin in bone metabolism by indicating serotonin regulates bone remodelling by mediating an inflammatory cytokine." 😹https://t.co/j4PTTnlZnChttps://t.co/xjOQlrbbcI

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6/9/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

Why do some children go thru growth spurts more than others?Why are children with crohn's disease abnormally short?How was it that I fixed my crohn's symptoms largely by boosting serotonin?https://t.co/QZSTPPUM07https://t.co/fWsKxC604A

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UltimApe@ultimapeover 5 years ago

Which I can infer is likely by direct action on microbiota driven calcium metabolism.Fun fact: if we want to go to mars one day, we may need to make our microbiome process calcium differently to avoid bone loss.https://t.co/aymdDJhpUc

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6/9/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

Cholesterol/Liver? nada"this study indicate that bone mineral density (BMD) is lower in boys with ASD compared with controls at the spine, femoral neck and total hip. These data raise significant concerns regarding bone health in this population"https://t.co/uegqCVCbDn

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6/9/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

Estrogen + Serotonin play role in bone development. But rarely find studies talking about cholesterol-calcium binding being done in bile. The way liver interacts with hormone production. Or how it regulates serotonin via it's impact on the gut.¯\_(ツ)_/¯https://t.co/2ool8bKKgr

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UltimApe@ultimapeover 5 years ago

No science, Only doge.https://t.co/9INukQWUBq

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6/9/2020
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

So many shrugs, so little time.https://t.co/Np8DCThCNn

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UltimApe@ultimapeover 5 years ago

I hate being on the frontiers. My brain is constantly pulling up ideas like "this should exist" or "we should expect interactions here", or "here's a game theoretic incentive system that ought to imply certain style of games among these actors."and yet all I find is ¯\_(ツ)_/¯

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6/9/2020
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UltimApe@ultimapeabout 5 years ago
Replying to @ultimape

So many shrugs, so little time.https://t.co/ohDWkgn7pS

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UltimApe@ultimapeabout 5 years ago

It's not 'repressed memories'It's stress induced reductions in serotonin in the gut leading to poor signaling in the hippocampus causing place/grid cells to not fire correctly. Fix the stress and the memories come back. Freud's got the model backwards!https://t.co/JoRagRV4GB

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6/20/2020
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UltimApe@ultimapeabout 5 years ago
Replying to @ultimape

I can replace and reference everywhere this paper on Learned Fear mentions CBD/Cannabidiol with associations found with driven gaba processes.https://t.co/dgajoqUrsDhttps://t.co/JNXLz6QIy4

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UltimApe@ultimapeover 5 years ago

My mental models of this space are strong enough to make really interesting connections.I read this tweet on serotonin and gaba https://t.co/sVLrZklDuWand predicted this idea:https://t.co/PRrBmLTb7h https://t.co/ScSfHlyI9g

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2 1
7/5/2020
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UltimApe@ultimapeabout 5 years ago
Replying to @ultimape

I watched "Dirty Pictures" - a documentary about the chemist who (re)discovered MDMA. They had a scene describing impact it had in a psychiatry setting.First think I looked up: https://t.co/33WUH7Eozk - It hits vagus nerve. Screams Gut-brain axis to me.https://t.co/acZa2na9jf

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UltimApe@ultimapealmost 8 years ago

"microbes… literally everywhere… 90% of our body's serotonin… communicate w/ vagus nerve… self-reinforcing cycle…" https://t.co/xummSNSBVI

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7/15/2020
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UltimApe@ultimapeabout 5 years ago
Replying to @ultimape

Because of that, I knew right away it was driving oxytocin (trust) + do wonders for PTSD.Vagus function suggest it impacts seizures. Sure enough, it can trigger a sodium imbalance. Likely causing intestines to not reabsorb bile acid?https://t.co/tAIZANbvGkIt's fascinating.

4 1
7/15/2020
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UltimApe@ultimapeabout 5 years ago
Replying to @ultimape

I can basically predict all the side effects of MDMA without even bothering to look them up. It's the same as what happened to me on SSRIs because of my weird serotonin mutations.https://t.co/CQEdfbGEz3

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7/15/2020
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UltimApe@ultimapeabout 5 years ago
Replying to @ultimape

Did you know that people w/ kidney issues are harder to treat safely with SSRIs?Kidney problems w/ MDMA: https://t.co/X7VksKVWhh"Serotonin (5HT) has significant effects on renal metabolism and glomerular function and is a potent renal vasoconstrictor"https://t.co/1XJouWvtXe

3 1
7/15/2020
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UltimApe@ultimapeabout 5 years ago
Replying to @ultimape

There is a lot more research we need to do in this space to be able to use drugs like MDMA safely.But we need to do it.https://t.co/g2XbBjlomH

4 1
7/15/2020
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UltimApe@ultimapeabout 5 years ago
Replying to @ultimape

But we can't because it's illegal."In 1985, The U.S. Drug Enforcement Administration (DEA) labeled MDMA as an illegal drug with no recognized medicinal use. "https://t.co/Dztwqrqhb1When I see stuff like this? I just see so much unnecessary pain. https://t.co/PLMC4fJPCl

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7/15/2020
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UltimApe@ultimapeabout 5 years ago
Replying to @ultimape

People are out there taking what they think is MDMA, not realizing they're likely ingesting something else entirely.Shits fucked.https://t.co/ARlQM4AD53And b/c of draconian and zealous approach in policing, this isn't going to change any time soon. So much potential, wasted. https://t.co/VS1EOG2cJR

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7/15/2020
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UltimApe@ultimapeabout 5 years ago
Replying to @ultimape

There are some really fun parallels: SSRI induced serotonin syndrome leading to high body temperature... and also many cases where SSRIs cause hyponatremia.And we give out these things out like candy while demonizing MDMA.This is idiotic.https://t.co/02gUbh8uCw

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UltimApe@ultimapeabout 5 years ago

I wish I had taken better care to track early research notes. I remember reading about benzodiazapine-like effects in context of Citalopram withdrawal.I'm scared of SSRIs after looking at my gene responses to them and reading all the case reports.https://t.co/aO6IleuNQs https://t.co/lejiC9KdsI

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7/15/2020
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UltimApe@ultimapeabout 5 years ago
Replying to @ultimape

Not just talking out of my ass here either.https://t.co/a1W04bOWDU

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7/15/2020
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UltimApe@ultimapeabout 5 years ago
Replying to @ultimape

The only drug I take regularly is a low dose of THC for muscle spasticity related to Multiple Sclerosis (concluded I don't need CBD to get effects of Sativex). I use alcohol (red wine) to condition my gut. I have never taken any "street drugs".

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7/15/2020
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UltimApe@ultimapeabout 5 years ago
Replying to @ultimape

I suspect, however, that I am in a natural state similar to that of psychedelics thanks to weirdness in my sleep + factors associated with autism/schizotypy.Apparently it isn't normal to think the way I do.https://t.co/hFhwQMTd4u

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UltimApe@ultimapeover 5 years ago

@mkaemingk I am now operating under a hunch that my brain wave pattern likely mirrors that of those on DMT. Hope to prove it in next year or two.

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7/15/2020
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UltimApe@ultimapeabout 5 years ago
Replying to @ultimape

Also worth noting that the THC is a new thing, and unrelated to reversal of my fear/anxiety.Low doses may be impacting my memory in a positive way.https://t.co/V8KdeJ1PdpAnd seems to mirror findings in age related decline.https://t.co/w6uBfI5eDkhttps://t.co/17h2pDZs9O

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UltimApe@ultimapeover 5 years ago

In other news, THC helps with immune related aches and pains from the Flu, and there's a good chance it might be helping me with M.S. symptoms. I like gifts.

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7/15/2020
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UltimApe@ultimapeabout 5 years ago
Replying to @ultimape

Was just exploring the same space in the brain WRT impacts of glycine and gaba on sleep."The Sleep-Promoting and Hypothermic Effects of Glycine are Mediated by NMDA Receptors in the Suprachiasmatic Nucleus" https://t.co/ThfeshCfnR https://t.co/KBho3kEctI

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7/16/2020
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UltimApe@ultimapeabout 5 years ago
Replying to @ultimape

Interesting to think that gut bacteria promoting bile acid synthesis might be playing a role with sleep via regulating salt levels somehow.https://t.co/7pPWt8gSI4

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UltimApe@ultimapeabout 5 years ago

Just ordered some Glycine to experiment with.Apparently it gets metabolized into methionine. https://t.co/D3kbXLxvlX

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5 1
7/16/2020
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UltimApe@ultimapeabout 5 years ago
Replying to @ultimape

I wonder how much L Casei and L Rhamnosus are impacting my sleep via glycine + gaba?https://t.co/umgyMRisJthttps://t.co/TyjF62piGP

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UltimApe@ultimapealmost 6 years ago

"Lactobacillus casei reduces CD8+ T cell-mediated skin inflammation."https://t.co/3s4Uyh7Ohs"The Absorption of Glycine and Alanine andTheir Peptides by Lactobacillus casei"https://t.co/3USqq8cvUo"Altered T cell responses in children with autism"https://t.co/Ed25GHPTIa

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7/16/2020
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UltimApe@ultimapeabout 5 years ago
Replying to @ultimape

Glycochenodeoxycholic acid is Glycine,Taurochenodeoxycholic acid is Taurine.Suggests both of these are important to have if you want functional bile acids.https://t.co/Xe4Z4wgOZV

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7/16/2020
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UltimApe@ultimapeabout 5 years ago
Replying to @ultimape

I wonder how much this plays into neuronal plasticity and fear reduction.https://t.co/84GBMkzYQf

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7/16/2020
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UltimApe@ultimapeabout 5 years ago
Replying to @ultimape

I think it is interesting how many of our commensal gut bacteria are salt-loving varieties. Lots of fermented meats are made via a salt rub. Kimchi/Sauerkraut is made by putting salt on veggies and letting oxalate eating bacteria take over. Etc. Etc.https://t.co/9hrRlKjhbW

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UltimApe@ultimapealmost 6 years ago

I'm just so fucking salty I guess."Our results connect high salt intake to the gut–immune axis and highlight the gut microbiome as a potential therapeutic target to counteract salt-sensitive conditions."https://t.co/Vvk6Z8fZci

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7/16/2020
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UltimApe@ultimapeabout 5 years ago
Replying to @ultimape

"[…] discontinued the shocks, the ordinary mice gradually learned not to fear the sound. But [those] with depleted or nonexistent microbiomes, the fear persisted — they remained more likely to freeze at the sound of the tone than the untreated mice did"https://t.co/t4AqXKcxd5

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7/16/2020
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UltimApe@ultimapeabout 5 years ago
Replying to @ultimape

🎭

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7/16/2020
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UltimApe@ultimapeabout 5 years ago
Replying to @ultimape

I know things that no sane person should ever know.https://t.co/1qd3LWbzOk

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UltimApe@ultimapeabout 5 years ago

A hypothesis in 1984 that talks about citalopram acting on parts of GABA as the possible anxiolytic (anti-anxiety) action.https://t.co/25fnxxIyN8GABA weirdness may be what's going on here?https://t.co/alaSg6iNED

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7/21/2020
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UltimApe@ultimapeabout 5 years ago
Replying to @ultimape

I wonder if MDMA does strange things to GABA.https://t.co/3B5um6xykb

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UltimApe@ultimapeabout 6 years ago

@HundredthIdiot Is MDMA the one that makes everything "Feel good" - like the touch sensation is enhanced? I get it confused with the side effects of meth.https://t.co/blqPdl6rXJ

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7/21/2020
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UltimApe@ultimapeabout 5 years ago
Replying to @ultimape

I am so curious about my sense of time being fucked.https://t.co/rWjtxdeFJO

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UltimApe@ultimapeabout 6 years ago

@realjdburnett @eigenrobot @HundredthIdiot Ok ok, now does MDMA fuck with your sense of time, like to the point where it's a noted side effect people report on?https://t.co/PwqKGbhB2X

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7/21/2020
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UltimApe@ultimapeabout 5 years ago
Replying to @ultimape

Imagine thinking the marshmallow test is meaningful and not a reflection of sugar loving gut bacteria and the impact of sweet tooth variance among children affecting risk tolerance driven by immune function & social stress. https://t.co/rBRibD2GJ2https://t.co/2eQWGVUXqR

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UltimApe@ultimapeover 6 years ago

Risk Tolerance and Loss Aversion are linked."Now that we know loss aversion is a key factor that drives risk tolerance, it is important for investors to take steps to reduce their loss averse tendencies."https://t.co/GmWiRsRY4Y

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8/20/2020
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UltimApe@ultimapeabout 5 years ago
Replying to @ultimape

Imagine thinking the marshmallow test is meaningful and not a reflection of sugar loving gut bacteria variance among children affecting social disposition and cooperation norms driven by immune function & social stress.https://t.co/UOiPwbUNmXhttps://t.co/ILcgLeaaWb

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UltimApe@ultimapeover 6 years ago

Remember when we thought that oxytocin played a role in autism, but found out that taking it directly did nothing... but then it turned out that L. Reuteri was helping to trigger the brain's production of it via action on the vagal nerve... via serotonin pathways?How to GABA?

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8/20/2020
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UltimApe@ultimapeabout 5 years ago
Replying to @ultimape

Imagine thinking the marshmallow test is meaningful & not a reflection of a different game being played by children that is impacted by social stress and immune changes that impact sense of fairness / risk & reflect trust of adults.https://t.co/3FWK3FjtA2https://t.co/kpIbzcXP7d https://t.co/oL2yM6gJ33

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UltimApe@ultimapealmost 9 years ago

"Of course, the game does not always works so smoothly in practice. How do the children play this game?"https://t.co/nBIsbfsxBD https://t.co/wgxfxau8xj

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8/20/2020
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UltimApe@ultimapeabout 5 years ago
Replying to @ultimape

I feel like the fundamental machinations of our entire society are based on false pretenses and the inertia of high-status scientists promulgating their misinterpretations. I am frustrated constantly by the scientific world.https://t.co/LR6W3NMMft

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UltimApe@ultimapeover 6 years ago

@alexeyguzey @The_Lagrangian But who would have thought to control for changing rates of sugar consumption and the impact on BDNF? https://t.co/KZulQSHFO4

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8/20/2020
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UltimApe@ultimapealmost 5 years ago
Replying to @ultimape

"Results support our model, revealing that inflammation predicts these outcomes even after controlling for factors that may contribute to a spurious linkage between them. [...] our model was a better fit for the data than alternative models"https://t.co/W99vImLZ7B

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9/28/2020
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UltimApe@ultimapealmost 5 years ago
Replying to @ultimape

"new evidence that fear and anxiety reflect overlapping brain circuits. [...] counter to popular scientific accounts, highlighting the need for a major theoretical reckoning. [...] distinction between 'fear' and 'anxiety' dates back to the time of Freud"https://t.co/1wJtIP7MMq

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10/21/2020
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UltimApe@ultimapealmost 5 years ago
Replying to @ultimape

What are you afraid of? Are you sure it's a real fear, and not the impact of trauma on your gut microbes leading to rumination?https://t.co/V3d1JyhUCq

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UltimApe@ultimapeover 5 years ago

from the wiki:"Past studies have shown that GABA aids in forgetting of fear memories in infancy and that it may be a general mechanism for regulating infant memory retrieval"Oh. LOL of course it is.

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10/21/2020
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UltimApe@ultimapealmost 5 years ago
Replying to @ultimape

Playing poker with the card castles I've toppled in my quest to rethink this space thru alternate utility.https://t.co/cT0JmLPUK5

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UltimApe@ultimapeover 6 years ago

Rethinking the foundations to fell the ivory towers. A house of cards if I've ever seen one.https://t.co/I3WuS3OPQT

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10/21/2020
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UltimApe@ultimapealmost 5 years ago
Replying to @ultimape

"But he was soon overwhelmed by the complications. Even dogs, he came to realize, had different personalities. Early on, he counted three “nervous types,” a number that later grew to more than 25." https://t.co/jkAPG8vleH

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12/3/2020
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UltimApe@ultimapealmost 5 years ago
Replying to @ultimape

I am thinking about dirty thoughts.It is said that orgasm and food reward share the same chemical response. I have to learn more about that.https://t.co/HcAcZDO40I

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UltimApe@ultimapealmost 5 years ago

I can't believe I was dancing around wet dreams this whole time. I hear that everytime some rings a bell, an angel gets it's wings.https://t.co/a5gRRpkI9Shttps://t.co/vX4uBuBXvd

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12/3/2020
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UltimApe@ultimapealmost 5 years ago
Replying to @ultimape

"He began by putting cats in a puzzle box and placing food outside of the box so that the cat wanted to escape. [...] Thorndike learned that the cats attempted to escape the box without the reward of food." https://t.co/IciI4epIId

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12/3/2020
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UltimApe@ultimapealmost 5 years ago
Replying to @ultimape

"Berridge discovered that blocking dopamine systems did not seem to change the positive reaction to something sweet (as measured by facial expression). In other words, the hedonic impact did not change based on the amount of sugar. "https://t.co/2TFo84OVXN

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12/3/2020
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UltimApe@ultimapealmost 5 years ago
Replying to @ultimape

"may evaluate someone as lacking in facial expressions, when, in reality, these expressions are just different to the ones they would produce themselves; a different style of emotional expression is falsely interpreted as a lack of emotional expression"https://t.co/xlRkkcULKP

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12/3/2020
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UltimApe@ultimapealmost 5 years ago
Replying to @ultimape

"The team from Columbia University found that the gut-brain axis (the connection between bacteria in your gut and your brain), is essential in the sugar preference of mice. "https://t.co/1AXrv95Xhm

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12/3/2020
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UltimApe@ultimapealmost 5 years ago
Replying to @ultimape

Its fun that I can just trivially refute basic findings in behavioral science at this point.I wonder how many people assume sweet is a reward and bitter is a punishment, and assume this is innate, but never test the assumption on the root cause.

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12/3/2020
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UltimApe@ultimapealmost 5 years ago
Replying to @ultimape

Your urethra responds to bitter because pathogenic bacteria's biofilms are relevant.https://t.co/SInxEtWAL4https://t.co/IVCgZfkNke

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UltimApe@ultimapeover 5 years ago

I have to remind myself this daily:"no, you can't taste anything with your testicles"https://t.co/SwYHUpkFyR

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1 0
12/3/2020
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UltimApe@ultimapealmost 5 years ago
Replying to @ultimape

After everything I've read on taste and the impact of microbiota on the brain, I'm half expecting bitter and sweet reward pathways to actually be modifiable via diet and methylation.https://t.co/f6WR3FWwEQ

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UltimApe@ultimapealmost 6 years ago

"For example, when pain was inflicted upon him, he could change his nerve receptors from transmitting pain to pleasure, allowing him to enjoy the injurious experience, saying to Aeryn while she twisted his arm, "Please, push harder,""https://t.co/CKWw7hIWkb https://t.co/HLiA4q6kkL

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12/3/2020
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UltimApe@ultimapealmost 5 years ago
Replying to @ultimape

"The current research shows, apparently for the first time, associations between different methylation patterns at olfactory pathway genes and adiposity indicators [...] which were independent of age and sex."https://t.co/vmjqEhDZQTSo why not taste?https://t.co/3kSV2oZPvf

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UltimApe@ultimapeabout 7 years ago

Dysgeusia is fascinating. Why do taste sensors seem to show up in parts of the body that deal w/ chemical concentrations, microbial management, or have a high need to maintain homeostatic / immune responses?We have taste receptors in our brain, ovaries/testes, pancreas, & anus.

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12/3/2020
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UltimApe@ultimapealmost 5 years ago
Replying to @ultimape

I wanna pull a hat trick and figure out what to feed people to bias their response to Asch.https://t.co/vtYVqMsaXe

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UltimApe@ultimapeover 6 years ago

So many conclusions from the asch conformity experiment doesn't take into account natural diversity among human swarms.https://t.co/jLe8YCAgk0

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12/3/2020
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UltimApe@ultimapealmost 5 years ago
Replying to @ultimape

That is to say, I wanna figure out how to make people autistic using diet and microbes... and just absolutely wipe the floor with leading scientists theories about behavior.https://t.co/NHU3Zr4Evj

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UltimApe@ultimapealmost 8 years ago

@jordanbpeterson @JonHaidt Oh, you mentioned the asch line experiment. That one's fun.There's some findings that people on the spectrum have reduction in conformity across the board: https://t.co/Hh6iEHkgyt I see this all the time in other social creatures.https://t.co/fdwpd9IGQl

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12/3/2020
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

We treat dogs like shit, and then treat humans like dogs.And then wonder why ABA therapy isn't working.https://t.co/mYs4gYSpz6

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UltimApe@ultimapeover 8 years ago

We've raised a generation of dogs to be conveniently helpless and depend on their masters. https://t.co/I0orDtUnJI

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1/18/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

👇https://t.co/Tbvg2yn24Q

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1/29/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

🐶https://t.co/9N2AwQVe7c

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UltimApe@ultimapeover 5 years ago

No Science, Only Dogehttps://t.co/Vc3rgY9Yqd https://t.co/G8wP6NN2aM

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1/29/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

¯\_🐶_/¯

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1/29/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

lol. We are apparently surprised that there is an enhanced synesthetic response in autism around taste and vision that corelates with social function?https://t.co/u23RATcWib

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2/11/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

I realized I was yawning when I need to pee.Made a connection in my head between doapmine and blood flow in the brain tied to bladder spasms.Went to look up if yawning correlated with urination.Found on Page 234https://t.co/UFqOfTsVOLNow this? This is surprising. https://t.co/u44BOd1F4H

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2/13/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

heh"Glutamate is an excitatory neurotransmitter in pathways that control the lower urinary tract. Serotonergic pathways facilitate urine storage. Dopaminergic pathways may have both inhibitory and excitatory effects on urination."https://t.co/fLAaF3skqPhttps://t.co/dTDM4ewMGg

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UltimApe@ultimapeover 5 years ago

Turns out urination frequency, concentration, and volume are actually medically relevant.https://t.co/6SS7VwhpTwSo I may be able to find out if dancing makes me pee.Awkwardhttps://t.co/8cwqAQ5EMb https://t.co/yuWjuIKOTS

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2/13/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

"And, using external transcranial magnetic stimulation (TMS), it was also possible to increase "excitability" in the motor cortex and therefore people's propensity for contagious yawns."https://t.co/NtbiX004Fo

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2/13/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

Yawning in anticipation, but in anticipation of what?https://t.co/bhngcm5cq4

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UltimApe@ultimapeabout 8 years ago

Can we use #quantifiedself techniques to measure yawning in dogs (and people?) to measure anxiety? 🤔😃https://t.co/qNQN0cAEUn

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2/20/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

"Our findings indicate that [Gut Microbiota] partially mediates and coordinates the effects of genetics on anxiety."https://t.co/hu642VUe1a

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UltimApe@ultimapeover 4 years ago

I'm going to go back to reading research on PTSD and the gut microbiome. You can keep parroting pop-psychology based on shit surveys to justify your world beliefs about power if you want; but one of my models is being proved out in mice as we speak https://t.co/qa9MKvWnX3

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3/9/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

Geek out, don't freak out.Wake up, don't break up.Restart, don't fall apart.When in doubt, go on walkabout?https://t.co/djxXyOtdstAssumptions.https://t.co/9pZFaLcCCU

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UltimApe@ultimapealmost 6 years ago

My assumptions here: complex regulatory network to modulate immune system response microbial colonies in our gut, driving both anxiety (gaba) and aggression (serotonin) to influence food foraging behavior under varying environmental constraints. https://t.co/lK65nwv35f

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3/9/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

"[exercise] changes brain chemistry, increasing the availability of important anti-anxiety neurochemicals, including serotonin, gamma aminobutyric acid (GABA), brain-derived neurotrophic factor (BDNF), and endocannabinoids"https://t.co/8HWRltuO3YOH SNAPhttps://t.co/lzp0bUFvpA

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UltimApe@ultimapeabout 7 years ago

"BDNF expression was found to be reduced in the hippocampus and cortex of germ-free “gnotobiotic” mice, and the reduction in the expression of BDNF was found to specifically associate with increased anxiety and progressive cognitive dysfunction"https://t.co/eztAbDnjZdOH SNAP

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3/9/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

"Nevertheless further studies are needed to fully understand the mechanisms that determine changes in the composition and functions of the microflora caused by exercise and all their related effects."https://t.co/FhXs9Mw73G

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3/9/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

"And, there’s preliminary evidence to suggest a tentative link between physical activity, gut microbes, and mental health, Campbell notes. “These correlations are out there,” she says. “The mechanisms . . . that’s what we are going to start to look at.”" https://t.co/iKE1SjOD3n

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3/9/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

“I choose a lazy person to do a hard job. Because a lazy person will find an easy way to do it.”― Bill GatesI'm not lazy. I have chronic fatigue associated with immune dysfunction shifts related to gut microbiota's impact on immune gene expression.https://t.co/EO9odiS7gH

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UltimApe@ultimapeabout 5 years ago

@0x49fa98 @HundredthIdiot I think a lot about how bears gain muscle while hibernating because they are lazy, and if eating chipmunk poop would fix my mental illness.

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3/9/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

How do I alter methylation and epigentic signaling pathways with gut bacteria? Asking for a friend.https://t.co/QZF639xxpE

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UltimApe@ultimapeabout 7 years ago

@37point78 @Honstomanian @Oo_O_o00o_O_oO @0xa59a2d @Cernovich The grasshoppers change to locust due to methylization pathways being affected by serotonin - which is downstream of their diet. Its basically an "epigenetic" effect driven by microbes and the body feeding back into each other..https://t.co/XqYss4H5E0

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3/9/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

PTSD -> inflammationhttps://t.co/waJACpVMGk

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UltimApe@ultimapeover 5 years ago

"Findings have not always been consistent in studies of cross-sectional associations between PTSD symptoms and inflammatory markers. A recent meta-analysis demonstrated that PTSD is associated with higher [IL-6, IL-1β, TNFα, & IFNγ] relative to controls."https://t.co/EEEA5Hj2dT

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3/20/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

Childhood Poverty -> Inflammationhttps://t.co/qWxvu4zM9XEpigenetic -> Inflammationhttps://t.co/Q0ukQF66r5Stress & Burnout -> Epigenetic Depressionhttps://t.co/hju1CTjOQREpigenetics -> Possibly mitigatable.https://t.co/vwEo7FQSwnFun https://t.co/KA0MWCMj7I https://t.co/8D0MdrY5z9

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3/20/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

Is "Revenge Bedtime Procrastination" is fake?Another interpretation is stress is killing gut bacteria that regulates serotonin/melatonin regulation leading to poor sleep. We're overlooking it thru psychoanalyzing anxiety behavior.https://t.co/5ic0eYPrYPhttps://t.co/hu642VUe1a https://t.co/X14z0FNLxZ

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UltimApe@ultimapeover 4 years ago

I'm going to go back to reading research on PTSD and the gut microbiome. You can keep parroting pop-psychology based on shit surveys to justify your world beliefs about power if you want; but one of my models is being proved out in mice as we speak https://t.co/qa9MKvWnX3

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5 1
4/20/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

"potential means to correct dysregulation of the host circadian rhythm associated with aging or chronicillnesses, such as metabolic syndrome, through the modification of the diurnally shifting microbiome."https://t.co/EPtO32xCSJ https://t.co/8m48amalyW

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1 1
4/20/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

MDMA for PTSD beginshttps://t.co/DMLfmpWiiz

1 1
6/7/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

Boo!"when the results were compared against another dataset from the same group – an analysis of the infants' stool samples, taken at both one month and one year of age – a link was found between the makeup of their gut microbiome and their fear"https://t.co/UmajwauiTA

1 1
6/7/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

Hives and red swelling of the skin in response to an SSRI."Here, we report an adult patient who developed acute urticaria and angioedema during treatment with fluoxetine."https://t.co/cuhFZemCsuhttps://t.co/RvnzakqY5g

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UltimApe@ultimapeover 5 years ago

SSRIs are weird. They trigger itch and runny noses in allergy free patients.https://t.co/FLu084W8KPhttps://t.co/KvY5dCAeqhand can induce full body allergic responsehttps://t.co/6gyR8Ow8bvWhathttps://t.co/OD2CqMVn3p

3 0
2 0
6/11/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

Hives as a delayed reaction to long term use of Wellbutrin"Of the antidepressants, bupropion may pose a higher risk of drug-induced urticaria, and this condition might be ignored due to the delayed onset phenomenon."https://t.co/gjv4NCjj8y

3 0
6/11/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

"by which the antidepressants achieve these effects are not understood, the recent recognition of a novel antidepressant-dependent form of angioedema may offer important insights into the mechanisms by which the antidepressants exert their effects." https://t.co/7b1pXZ8Q0v

1 0
6/11/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

Cases of spontaneous urticaria are dismissed."At the time of development of urticaria, she was on long-term venlafaxine and dexamphetaminefor a mood disorder. There was no history to suggest an allergic reaction to current medications."https://t.co/xBPHxVTjfs

2 0
6/11/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

Why would anyone suspect SSRIs to impact allergen factors associated with gut bacteria?"demonstrated that the microbial composition was significantly different between [chronic urticaria] patients and the healthy individual"https://t.co/grn55EGNf8https://t.co/hRCIElKkdd

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UltimApe@ultimapeabout 6 years ago

'Dose‐dependent seizure activity associated with fluoxetine therapy'https://t.co/ADjHhmO7df'Fluoxetine Overdose-Induced Seizure'https://t.co/SjSQsEtsEB'The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet'https://t.co/HbIub6MKFs

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2 0
6/11/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

Why do allergic responses disappear when I drink lactic acid bacteria prebiotics?"Our study showed that some types of gut microbiota are found in normal individuals in a higher amounts than patients with chronic spontaneous urticaria."https://t.co/wXyBKX9UuT

1 0
6/11/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

Must be the stress /shttps://t.co/6HYSzjdlLN

1 0
6/11/2021
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

"A giant photograph of Harvard psychologist B.F. Skinner, founder of the theory of behaviorism and patron saint of ABA, is visible in the background."https://t.co/cBfBopK5ebhttps://t.co/AcHuqXEIW0

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UltimApe@ultimapeover 4 years ago

Project Pidgeon? BF skinner was a dork. https://t.co/aiDyTAJXBMhttps://t.co/1XwkXlB4uF

0 0
0 0
2/2/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

Skinner box.https://t.co/5a7o4nhHcy

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UltimApe@ultimapeover 4 years ago

Licking operant conditioning's taint."Our work questions the dominant view that equates value with reward, showing how a change in goals triggers a reorganization of the neural representation of value, enabling flexible behavior."https://t.co/licj47ww4m

1 0
0 0
2/2/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

"If they could train a pigeon to guide a bomb, they reasoned, they could probably train other animals to do extraordinary things. And if they could do that, there was probably money to be made."https://t.co/XSd4TnuVP4

2 0
2/2/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

Will weaponize my autism for fruitloops.https://t.co/YnkRBsMhX5

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UltimApe@ultimapeover 4 years ago

Hired: putting a rat in a tiny car to see if you can use them to navigate robot dogs using drone based telerobotic systems.I'm sure they don't realize this is what is going to be done with it. But hey, at least the rats are happy and get fruitloops.https://t.co/UpqHv2dDtv

2 0
1 1
2/2/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

I'm not afraid anymore.I am angry tho.https://t.co/u2n2xyzHPR

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UltimApe@ultimapeover 4 years ago

I'm arguing and emotionally reactive. I'm sorry. "The findings suggest that when serotonin levels are low, it may be more difficult for the prefrontal cortex to control emotional responses to anger that are generated within the amygdala."https://t.co/oW1RaelmlR

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0 0
2/2/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

Disgusted, perhaps? Frustrated? Annoyed? https://t.co/P9R4rmhp7v

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UltimApe@ultimapeabout 9 years ago

"the distinction between anger and disgust and between surprise and fear, is socially, not biologically based." https://t.co/HzXPgHaSyi

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0 0
2/2/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

No. Protective."Rats, in contrast, seem to have some sort of emotional response that triggers helping. Mason and her colleagues have found that giving rats an anti-anxiety drug seemed to take away their urge to release a distressed rat from a trap."https://t.co/v143cqhlpO

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UltimApe@ultimapealmost 8 years ago

Antidepressants make rats stop caring about their friends?https://t.co/DmbzU0AERL https://t.co/tpkKd9QYED

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0 0
2/2/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

Anti-anxiety "benzodiazepine anxiolytic MDZ" (midazolam) => GABA sensitivity => not care about friends? or does this just make them idiots?https://t.co/WRqyhnjbt1 https://t.co/gOXNhXkmyL

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2/2/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

"Practically all effects of the benzodiazepines result from their actions on the ionotropic GABA(A) receptors in the central nervous system. Benzodiazepines do not activate GABA(A) receptors directly but they require GABA." https://t.co/E3cifmTQaS

2 0
2/2/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

"concentration of midazolam in the brain 180 min after administration was about 14-fold higher in GF mice compared with SPF mice. [...] demonstrated that the gut microbiota altered the metabolic ability of Cyp3a and the tissue accumulation of midazolam." https://t.co/0rQgWVHiyS

1 0
2/2/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

"Overall, knowledge of how the microbiome responds to exogenous influence remains limited. [...] We suggest the definition of psychobiotics be expanded beyond probiotics and prebiotics to include other means of influencing the microbiome." [2016] https://t.co/cW9fg3zxtL

0 0
2/2/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

Oh neat. I wonder what else hits dopamine in the nucleus accumbens...https://t.co/4wZpQk0ISLhttps://t.co/39l9McJeCx

1 0
2/2/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

"response to cocaine was normalized in antibiotic treated animals upon supplementation with [SCFAs], major biproducts of microbial fermentation, suggesting an indirect path for the microbiota to influence reward behavior" [2018] https://t.co/UvQvsBMdOhhttps://t.co/fynMQtUR58 https://t.co/QTtLBT6V8U

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UltimApe@ultimapealmost 6 years ago

Google search seems to confuse Cathiones with Cocain.Still this is interesting: Just like how microbiota impact drugs that impact Parkinsons, it also mediates the effect many illicit drugs.https://t.co/DDFlfFM8xi

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5 2
2/2/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

Weird to see Sigmund Freud / behavioral psychology and Cocaine all tie in with ideas of microbiome twice in the same day.https://t.co/tHHpzxEwCT https://t.co/HZa3bxP5UV

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UltimApe@ultimapeover 3 years ago

Does Cocaine makes you constipated? Vasoconstriction aught to lead to direct gut motility problems and exhibit the issues we seen in Crohn's Disease / IBS-C.https://t.co/D6RrU6S5L6https://t.co/mVvIyclAtO https://t.co/lDkssYq3zN

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1 0
2/2/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

Ya'll ever eat a bunch of herbal remedies after being given something to induce vomiting/diarrhea to g̶e̶t̶ r̶i̶d̶ o̶f̶ s̶o̶m̶e̶ d̶e̶m̶o̶n̶s̶ p̶o̶s̶s̶e̶s̶s̶i̶n̶g̶ y̶o̶u̶ reset your gut and improve insulin/lipid function to target mTORC1 related pathways?https://t.co/2CRnwyK3rs

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UltimApe@ultimapeover 3 years ago

I wanna recreate all the learned helplessness experiments but sample gut metabolome and microbiome. The variation in the dogs was really high IIRC. Rats + mice studies are already suspect because of completely ignoring water+food+environmental pathogens.https://t.co/9e7BEtSI2i https://t.co/6gBtyNxLiJ

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3 0
2/23/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

Why would epigenetic factors around stress covary between parent and child?https://t.co/ZqrNoXE2zd https://t.co/cd6big72xw

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3/14/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

Could it be.... that gut bacteria and diet is largely heritable? and stress is driven by this space?https://t.co/t8C6IsgRyU https://t.co/8v8GkIVIzK

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3/14/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

Sure is funny how many antidepressants are actually antiinflammatory and antibacterial in nature.https://t.co/FdATajJljm https://t.co/Rc0ooOqcdt

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3/14/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

Sure. give your mouse some Fluoxetine. It helps the stress and depression.Or maybe what you're really doing is killing a fungal infection driving insulin resistance and inflammation tied to a fungus's demand for high sugar diet? https://t.co/UsiqgWSR1Y

4 0
3/14/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

Sure wish there was some explanation for the link between anti-fungal associated cytokine pathways and the endocannabinoid system as it relates to immune signaling via endocannabinoid system.https://t.co/DGB6S49X0w

3 0
3/14/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

What could be going on here?"Surprisingly, therapeutic administration of L. reuteri to stressed mice improves metabolic homeostasis and corrects stress-induced despair behaviors."https://t.co/UkHCrWirYK ¯\_ (ツ)_/¯https://t.co/n18GQxVdkk

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UltimApe@ultimapeover 3 years ago

@tszzl L Reuteri - a gut bacteria that helps with IBS symptoms. Seems to promote the production of oxytocin in the brain via the gut-brain axis and is being researched as a way to mitigate some autism symptoms.It's antifungal.https://t.co/qHa5QFktDx

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3 0
3/14/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

"I drive these brothers crazy, I do it on the daily [...]You can look, but you can't touch itIf you touch it, I'ma start some TraumaYou don't want no TraumaNo, no Trauma, no, no, no, no Trauma"🎶https://t.co/rKdXxFTEpvhttps://t.co/ALaAvfcX1W

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UltimApe@ultimapeover 3 years ago

@nosilverv @yashkaf @msutherl @MechanicalMonk1 @natural_hazard If you really really need your world view to stay inline with trauma model of disease. consider at least this model of childhood trauma causing gut dysbiosis https://t.co/JzzRfpVAEj

6 2
1 0
3/14/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

Tired: Daddy issues.Wired: Doggy issues.https://t.co/Q4puMRqL9K

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UltimApe@ultimapeover 4 years ago

No one realizes how important Freud's dog was to his ability to diagnose and treat patients.Dogs can smell fear.Humans can too. If you know how.https://t.co/DZHzeFOtJK

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1 0
3/14/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

We have no idea what we're doing.https://t.co/x1EorCZvJh

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UltimApe@ultimapeover 3 years ago

"mood stabiliser lithium and the antidepressant fluoxetine, influenced the composition and richness of the gut microbiota. Although some [...] drugs have been previously investigated in in vitro settings, this is the first evidence in an animal" [2019]https://t.co/z6crEpCft1 https://t.co/mKN2FwQwZa

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3 0
3/14/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

"In this study, we observed that the human infant gut microbiome is also associated with differences in observed fear reactivity." https://t.co/pt8ewwrP2t

1 0
4/17/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

*licks the bees*https://t.co/KX4atFot4o

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UltimApe@ultimapeover 5 years ago

"Despite attempts to consider bees in behaviorist terms, honeybee learning is much more complex than traditional classical and operant conditioning."https://t.co/tnHa62GZT8

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1 0
4/17/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

So much licking.https://t.co/5a7o4nhHcy

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UltimApe@ultimapeover 4 years ago

Licking operant conditioning's taint."Our work questions the dominant view that equates value with reward, showing how a change in goals triggers a reorganization of the neural representation of value, enabling flexible behavior."https://t.co/licj47ww4m

1 0
1 0
4/17/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

If you lick the taint long enough, you can start to smell it in the model making of experts.Operant conditioning is for cattle.https://t.co/maYOU1nluw

1 0
4/17/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

"Furthermore, the results of the open-field observations may suggest that social differences in the BTBR strain are anxiety induced." https://t.co/FCQws3jvSNhttps://t.co/IBZLWCK3iA

0 0
4/17/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

> anxiety induced💅"Taken together, our findings indicate that alteration of GM in BTBR mice shows relevant sex-associated differences and supports the use of BTBR mouse model to dissect autism associated microbiota-gut-brain axis alteration." https://t.co/zen1qMeXbY

2 0
4/17/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

"These results suggest that while the anxiety responses of BTBR mice to novel situations (EPM and zero-maze) are inconsistent, BTBR mice appear to be more defensive to animate threat stimuli (predator or another mouse)." https://t.co/MD9xxSTYWX

1 0
4/17/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

"Taken together, our data show that treatment with L. reuteri selectively reverses the ASD-like social deficits in genetic, environmental, and idiopathic models of ASD." [in mice] https://t.co/FVonSfICj7 https://t.co/uhg2e8aKKa

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4/17/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

It licks the sour milk or it gets the fear again.https://t.co/t683AUor2S

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UltimApe@ultimapealmost 7 years ago

Oh hey, look at that... L. Reuteri is the exact strain I chose when selecting @lifeway_kefir as my source of probiotics and lactic acid.Weird eh? https://t.co/mk3re2dGf3

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4 0
4/17/2022
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UltimApe@ultimapeabout 3 years ago
Replying to @ultimape

"assumption here is that microglia hold the key to cementing these memories and underpinning what is forgotten and what is retained. The study goes on to show that it is the rearranging of the connections within the mice that leads to this observation" https://t.co/rNwMNb1sFA 🤓

2 0
8/31/2022
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UltimApe@ultimapeabout 3 years ago
Replying to @ultimape

Boy, I sure do have an axe to grind where it comes to flaws within the field of behaviorism and learning, huh.https://t.co/2CRnwyK3rs

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UltimApe@ultimapeover 3 years ago

I wanna recreate all the learned helplessness experiments but sample gut metabolome and microbiome. The variation in the dogs was really high IIRC. Rats + mice studies are already suspect because of completely ignoring water+food+environmental pathogens.https://t.co/9e7BEtSI2i https://t.co/6gBtyNxLiJ

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2 0
9/2/2022
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UltimApe@ultimapealmost 3 years ago
Replying to @ultimape

This looks like a good book for quickly bootstrapping into a model the thoughts of modifying behaviors from the zeitgiest in the 1970s (ABA was first introduced in ~1959)https://t.co/N8g6vwNGOJhttps://t.co/e8TzwPvCvL https://t.co/JJHWAk3k3n

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9/27/2022
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UltimApe@ultimapealmost 3 years ago
Replying to @ultimape

I've had to undermine basically all of the field of aging and all of behavior theory to figure out how to change my behavior.https://t.co/oR8YJnlCCDhttps://t.co/hSqpuJPCE2 https://t.co/0WXW0Isn0f

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UltimApe@ultimapealmost 3 years ago

Prepping a large thread on DNA repair, and what I suspect it's it's role in autism etiology and possible relationship to telomeres and aging as it relates to my thinking on immune function. (with emphasis on Tylenol and related risk factors for autism https://t.co/ejeZa7khem)

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2 0
9/27/2022
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UltimApe@ultimapealmost 3 years ago
Replying to @ultimape

I'm basically retarded. I was non-verbal during most of my grade school career and it is reflected in all of my report cards.https://t.co/vE4q2DkmfA

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UltimApe@ultimapeover 3 years ago

I changed my profile to the joker because I think it's funny to call myself a Retarded Autistic Psychopath.If I get banned for this post it would give me joy because gatekeeping is my fetish. Go ahead, click that report button. I'm a sadist. Turn me on.https://t.co/hwZnAoM8WE

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3 0
9/27/2022
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UltimApe@ultimapealmost 3 years ago
Replying to @ultimape

Learning how to fix my health issues and figure out what was wrong with my brain is easy.The hard part is figuring out how to fix the institutional and cultural norms that make this stuff keep happening.

3 0
9/27/2022
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UltimApe@ultimapealmost 3 years ago
Replying to @ultimape

I want a brain wearable that can help people like me display when they are in pain to doctors, teachers, and parents.But not other children... who will use it to gamify torture.https://t.co/RPzW6vhBZJ

3 0
9/27/2022
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UltimApe@ultimapealmost 3 years ago
Replying to @ultimape

There are a lot of 'profoundly autistic' people who didn't get lucky to have a disabled parent. Someone who had the time to spend to teach them how to read and write. Like all the hours my mom spent with me, teaching me how to use words and hold a pencil.https://t.co/n3arVhmmx5

2 0
9/27/2022
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UltimApe@ultimapealmost 3 years ago
Replying to @ultimape

I can speak most to the time these days. But I have an agreement with my GF that if I pull out my phone to type to her that she understands I'm having trouble with words.https://t.co/KqBaoNqP2W

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UltimApe@ultimapeabout 6 years ago

"I'd meet this beautiful girl that was also a deaf-mute and we'd get married. She'd come and live in my cabin with me, and if she wanted to say anything to me, she'd have to write it on a piece of paper, like everybody else"https://t.co/fPMyFHW7CR

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0 0
9/27/2022
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UltimApe@ultimapealmost 3 years ago
Replying to @ultimape

I learned to type when I was in like 1st grade. Then all my schools we moved to forced me to use a pencil that I couldn't hold due to hand coordination problems.

0 0
9/27/2022
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UltimApe@ultimapealmost 3 years ago
Replying to @ultimape

Funny how I suddenly got better at writing when they let me type on a keyboard. Even ended up getting such a high score on my PSATs that I drove up the average of the school district. I got in the newspaper because it was so high.

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9/27/2022
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UltimApe@ultimapealmost 3 years ago
Replying to @ultimape

I was getting bad marks because of dyslexic issues and spelling mistakes. So it made me disgusted when my teachers were praised for teaching me so well.No, fuck you. I read the dictionaries on my own cuz you specifically weren't helping me.https://t.co/by0XsAa8vj

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UltimApe@ultimapeover 9 years ago

"Handwriting and spelling errors were found in 89% of suicide notes left by adolescents" https://t.co/IHyCVTFzae

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0 0
9/27/2022
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UltimApe@ultimapealmost 3 years ago
Replying to @ultimape

These institutions are broken. I don't know if I can fix them. I have it in my head that I can figure out how to undermine them by fixing the health problems that make people like me struggle. https://t.co/PLLuaaSBmR

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UltimApe@ultimapeabout 4 years ago

One of my friends in highschool got kicked out when he had a tantrum threw a chair at his teacher. He was brilliant.I learned more valuable lessons about physics from him teaching me about bicycles & skateboarding than I did from physics class that year.https://t.co/EMhXWDFzNI

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0 0
9/27/2022
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UltimApe@ultimapealmost 3 years ago
Replying to @ultimape

I might be retarded. But the entire western world and the institutions we depend on is absolutely bat shit. https://t.co/t9xOWcHkIn

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UltimApe@ultimapeabout 3 years ago

Call me a eugenicist because I wanna fix gut bacteria so we stop trying to remove genes from the gene pool in our ignorance.

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1 0
9/27/2022
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UltimApe@ultimapealmost 3 years ago
Replying to @ultimape

I feel like that mouse who didn't like peanut butter, so they assumed it was dumb for not being good at solving mazes.https://t.co/mPoQkITXTv

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UltimApe@ultimapeover 3 years ago

Officially ignoring all conclusions derived from mice maze studies. https://t.co/Ji7G6kMYidhttps://t.co/oUfQokBB9B https://t.co/MmeapoeiL9

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7 1
9/27/2022
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UltimApe@ultimapealmost 3 years ago
Replying to @ultimape

If I just stand in this corner of the maze long enough, the teachers let me go home on the bus and I can go outside and play with our pet turkey and make sure my mom isn't dying.

1 0
9/27/2022
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UltimApe@ultimapealmost 3 years ago
Replying to @ultimape

Whoa, neat."Parental olfactory experience influences behavior and neural structure in subsequent generations"https://t.co/4Kl2HYIu1whttps://t.co/16nSvmUOh3

1 0
11/30/2022
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UltimApe@ultimapealmost 3 years ago
Replying to @ultimape

If the fear memory trigger is epigenetic reprogramming via immune system and bacteria, that might explains some neat things.https://t.co/2CRnwyKBh0

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UltimApe@ultimapeover 3 years ago

I wanna recreate all the learned helplessness experiments but sample gut metabolome and microbiome. The variation in the dogs was really high IIRC. Rats + mice studies are already suspect because of completely ignoring water+food+environmental pathogens.https://t.co/9e7BEtSI2i https://t.co/6gBtyNxLiJ

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2 0
11/30/2022
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UltimApe@ultimapealmost 3 years ago
Replying to @ultimape

Seems easy to test. Scare one mouse then see if you can transfer the scent fear memory into a germ free mouse pup (account for time for reprogramming to impact brain).May be able to see if it also has impact in flatworms.https://t.co/V2quQDkP5r

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UltimApe@ultimapeover 4 years ago

@The_Lagrangian @insurrealist "Researchers discover flat worms retain memories even after decapitation"https://t.co/nkhPKa9X6rhttps://t.co/Qzk81HIiRN

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11/30/2022
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UltimApe@ultimapealmost 3 years ago
Replying to @ultimape

"Here we show that they can express genes present in plasmids carried by bacteria and those that are encoded by naked DNA [...] they can also express genes taken up during feeding"https://t.co/n4HozxfZGk https://t.co/qqLjQkPUTs

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11/30/2022
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UltimApe@ultimapealmost 3 years ago
Replying to @ultimape

Plasticity? Fear. Intergenerational Trauma?Ergo, I hum a song about trauma."No one ever listens[…]Uh oh, she's coming to the attic, plasticGo back to being plastic[…]D-O-L-L-H-O-U-S-EI see things that nobody else sees" 🎶https://t.co/oJbaYM0ViYhttps://t.co/0KSIb4KwZO

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UltimApe@ultimapeabout 3 years ago

"Because epigenetic and plant-associated (micro-) organisms are both key sources of phenotypic variation allowing environmental adjustments, we argue that they must be considered in terms of evolution" https://t.co/KDYCoon1yS

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11/30/2022
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UltimApe@ultimapealmost 3 years ago
Replying to @ultimape

Thinking a lot right now about how DNA repair mechanisms and epigenetics / immune function all impacts semen quality. TL;DR: what if trauma is actually stored in the balls?

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11/30/2022
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UltimApe@ultimapealmost 3 years ago
Replying to @ultimape

I think about this meme a lot.https://t.co/uJdywtEIgq https://t.co/24UeZagnMG

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11/30/2022
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UltimApe@ultimapealmost 3 years ago
Replying to @ultimape

Stress & Trauma 🤝 Genetics & Gut Bacteriahttps://t.co/ezgQok1B1M

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UltimApe@ultimapeabout 3 years ago

@__________1890 @Outsideness @realMaxCastle @nihilaxis All of western psychological gestalt believes trauma can be passed on from mother to child. Most of of evo-psychos believe traits are genetic inheritance.No one is looking at impact of stress on gut bacteria & how they are viable means for evolutionary processes to accumulate.

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11/30/2022
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UltimApe@ultimapealmost 3 years ago
Replying to @ultimape

Cortisol is a major bacterial signaling molecule.https://t.co/kkgs12O4Hl

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11/30/2022
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UltimApe@ultimapealmost 3 years ago
Replying to @ultimape

Intergenerational standing waves.https://t.co/0C6ZRAyKEl

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UltimApe@ultimapeabout 3 years ago

"Think of them like genetic parasites, jumping around the genome to selfishly replicate themselves, and sometimes jumping between species." [2018] https://t.co/aTpx3HWWqBhttps://t.co/m03twABa8I

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11/30/2022
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UltimApe@ultimapeabout 2 years ago
Replying to @ultimape

"These results demonstrate that colon-delivered SCFAs modulate hypothalamic-pituitary-adrenal axis reactivity to psychosocial stress, thereby supporting their hypothesized role in microbiota-gut-brain communication." [2020]https://t.co/Bm7F9ggwtFhttps://t.co/JxV9YWbL7D

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UltimApe@ultimapeover 3 years ago

I got curious about curiosity, and realized that our model of fear and trauma is wrong.https://t.co/5LQ24EdpIh

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6/26/2023
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UltimApe@ultimapeabout 2 years ago
Replying to @ultimape

Environmental enrichment => stress reduction => healthier immune system => improved gut => less fear => improved resistance to cocaine.Solving mice mazes in the meta.https://t.co/Qis4d851FU

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UltimApe@ultimapeover 3 years ago

"response to cocaine was normalized in antibiotic treated animals upon supplementation with [SCFAs], major biproducts of microbial fermentation, suggesting an indirect path for the microbiota to influence reward behavior" [2018] https://t.co/UvQvsBMdOhhttps://t.co/fynMQtUR58 https://t.co/QTtLBT6V8U

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6/26/2023
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UltimApe@ultimapeabout 2 years ago
Replying to @ultimape

The mice swim longer when they are not depressed and anxious? Have reduced fear response? https://t.co/z58W0ZErU5

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UltimApe@ultimapeover 2 years ago

Have you tried expanding your blood vessels so you can swim for weeks without rest?What could he have meant by this?> "Some studies suggest that the community of microorganisms that live in the gut are associated with athleticism."https://t.co/XUjIa3uyVo

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6/26/2023
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UltimApe@ultimapeabout 2 years ago
Replying to @ultimape

"A microbial compound in the gut leads to anxious behaviors in mice" [FEB 2022]https://t.co/0ClH1wXjSm

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6/26/2023
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UltimApe@ultimapeabout 2 years ago
Replying to @ultimape

"Fear Potentiation is Associated With Hypothalamic-Pituitary-Adrenal Axis Function in PTSD" [2011]https://t.co/xeAG2rDHQiSolving my autism fear reactivity by revere engineering how the gut impacts PTSD, lmao.https://t.co/eEUCqHZdTC

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UltimApe@ultimapealmost 9 years ago

"suggests increased reactivity of the HPA axis to stress and novel stimuli in children with autism." https://t.co/kvNp53G1ba https://t.co/89v78GAYzt

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6/26/2023
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UltimApe@ultimapeabout 2 years ago
Replying to @ultimape

It's always the same thing.https://t.co/c4QFySfb4Q https://t.co/N19Oq4W6bu

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UltimApe@ultimapeover 7 years ago

@Tipsycaek @kevin_bowen @PDGumshoe Ahh, sensory processing issues, yeah. I've tracked my own to something to do with my amygdala and a stress response, possibly being enhanced by "sensory motor gating" abnormalities that occur often autism/schizophrenia. Its is my biggest hurdle.https://t.co/pQrZ5NphKy

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6/26/2023
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UltimApe@ultimapeabout 2 years ago
Replying to @ultimape

Must be the stress. Must be the trauma. Must be the learned helplessness.Must be wrong.https://t.co/BFSIPexsb1

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UltimApe@ultimapeabout 5 years ago

Next, you'll be telling me how consuming one of primary precursors for the production of endocannabinoids (one that also contributes to feeding the gut bacteria responsible for serotonin production), ends up protective against PTSD.But muh stress tho. /shttps://t.co/iHI4FmwuJu

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6/26/2023
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UltimApe@ultimapeabout 2 years ago
Replying to @ultimape

"People who experience anxiety symptoms might be helped by taking steps to regulate the microorganisms in their gut using probiotic and non-probiotic food and supplements, suggests a review of studies published today in the journal General Psychiatry."https://t.co/Q0d7TVkDRY

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6/26/2023
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UltimApe@ultimapeabout 2 years ago
Replying to @ultimape

"thus, we demonstrate for what is to our knowledge the first time that the presence of the host microbiome is crucial for the appropriate behavioural response during amygdala-dependent memory retention." https://t.co/PiFjKEtmMEhttps://t.co/gkA3NTppXX

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UltimApe@ultimapealmost 9 years ago

What does your fear say?"Activation of the amygdala by threatening stimuli then influences cognitive processes" https://t.co/s8cBEzyJoH https://t.co/9b91tKKAB5

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6/26/2023
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UltimApe@ultimapeabout 2 years ago
Replying to @ultimape

'autism serverity may stem from fear'?No. It stems from gut bacteria's impacts on fear. https://t.co/BZzYNpcjsg

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UltimApe@ultimapeover 3 years ago

I am looking for firms that might be exploring fear extinction and not just gaze/behavior training.There's some interesting studies around fear's impact on autism symptoms https://t.co/rgiSn6jZIG that seems to line up with oddities in the amygdala.

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6/26/2023
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UltimApe@ultimapeabout 2 years ago
Replying to @ultimape

"Germ-free mice transplanted with PTSD microbiomes compared with those receiving resilient microbiomes exhibited anxious behavior" [2022]https://t.co/ScPYiHgy8t

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8/14/2023
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UltimApe@ultimapeabout 2 years ago
Replying to @ultimape

"Our study is limited by the relatively small sample size: male veterans and PTSD related to combat in those with cirrhosis. Therefore, the results may not be generalizable to women and noncombat PTSD." https://t.co/fS6tiBjrTG

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8/14/2023
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UltimApe@ultimapeabout 2 years ago
Replying to @ultimape

"Manipulation of the microbiota reversed the behavioral and biochemical changes induced by the [chronic mild stress] protocol, and the vagus nerve influenced the gut–brain axis response." [DEC 2020]https://t.co/lHu4EVDNBmhttps://t.co/DB8Hyen9r6

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UltimApe@ultimapeabout 5 years ago

Did you know the guy who coined "fight or flight" was very interested in the nature of the vagus nerve and the role it plays in the nature of gut motility?https://t.co/OVAzZrQKZZ

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8/14/2023
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UltimApe@ultimapeabout 2 years ago
Replying to @ultimape

"MDMA-assisted therapy is highly efficacious in individuals with severe PTSD, and treatment is safe and well-tolerated, even in those with comorbidities." [May 2021] https://t.co/F28tnm6i1jhttps://t.co/WHqL8q7whm

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UltimApe@ultimapeabout 5 years ago

There is a lot more research we need to do in this space to be able to use drugs like MDMA safely.But we need to do it.https://t.co/g2XbBjlomH

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8/14/2023
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UltimApe@ultimapeabout 2 years ago
Replying to @ultimape

Going to ask my mom if she'd rather eat dog shit or take medical MDMA after I figure out what MDMA destroying serotonin neurons via" mTOR-independent autophagy" is about.https://t.co/JasPK0zefthttps://t.co/rEhqv59o9i

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UltimApe@ultimapealmost 3 years ago

Never read this before today."The present findings suggest that the microbiome-gut-brain axis may play a contributory role in the hyperthermia mediated by MDMA." [2019]https://t.co/UMKcWicIgh

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8/14/2023
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UltimApe@ultimapeabout 1 year ago
Replying to @ultimape

many have been saying this https://t.co/iFLZduMwGo

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MAGE THE COURAGEOUS {❤️‍🔥}@myceliummageabout 1 year ago

I HAVE BEEN SAYING THIS

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7/3/2024
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UltimApe@ultimape2 months ago
Replying to @ultimape

https://t.co/OSnJBI43tz

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UltimApe@ultimapeover 3 years ago

The reason I got into genetics was to solve my pain. To figure out why my mom was sick. Maybe answers were there? Maybe science had solutions? They didn't. I kept looking. I hurt less now than before. I am thankful for this. But there is more to be done. https://t.co/3G4w6kNyF8

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7/5/2025
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james, the giant peach@JimmyRisover 5 years ago
Replying to @ultimape

@ultimape https://t.co/qfFW8FlaiE https://t.co/0S8ShmeW4V

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12/27/2019
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james, the giant peach@JimmyRisover 5 years ago
Replying to @ultimape

@ultimape https://t.co/qfFW8FlaiE https://t.co/0S8ShmeW4V

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12/27/2019