🧵 View Thread
🧵 Thread (109 tweets)
Ants are tiny self-replicating roombas powered the crumbs they pick up. The undomesticated kind plant seeds, which act as long term energy harvesting systems that absorb material from the earth/air and generate ATP using the sun.House ants should be treated as friendly daemons. https://t.co/TDuJ0AxTEj
I'm still trying to figure out how to leverage mice as house-elves... A swarm of small big-ear'd things that help tidy up the workplace?https://t.co/z8Qhfm6Ucq
What's really funny is that... this isn't a one-off phenomena!https://t.co/GdcQTraBXj
Undomesticated mice can also be trained to plant things…"It adds a new dimension to our understanding of the ongoing battle between plants and animals, [...] In this case, the plants have twisted the animals to do their bidding, to spread their progeny"https://t.co/es60q8bL1e
"And then what they'll do is they'll urinate on you because that's how they mark their trail. The thing you have to not mind, working with mice, is that you go home at night with a lot of mouse (urine) on you. My cat would be intrigued;"https://t.co/ATX9CNLy4a
Getting a mouse to trust you is a lot harder than giving them a cookie.https://t.co/1Jgs78CE3n
I'm exploring ways of interacting safely with wild mice (and squirrels). There are a lot of diseases they can harbor. https://t.co/G1HdGi1OkqAnd rat-bite fever is pretty scary.https://t.co/JSnJx9jSVU
There's talk about using gene-edited mice to help them fight against the transmission of lyme disease. The thinking is that lyme is being passed from tick-to-tick via their hosts, so if we can stop mice as a vector, it might reduce the spread.https://t.co/k5N2DFFIbb
Figuring out ways to safely handle mice - and what kinds of things make them upset or stressed - is very important if you want to do non-invasive observational studies on them.It also helps understand how research is conducted related to disease.https://t.co/pklf2pMrPO
The last thing in the world I want is to raise a small colony of mice and then have them eat each other due to stress.https://t.co/FApwVhuZVP
But there is this weird chasm to cross. Since we don't really have any strong idea 'why' that kind of thing occurs, doing studies to avoid it are inherently risky. It would be absolutely monstrous to do experiments like this: https://t.co/nuB59mzXTY
Everything I've read on the mice plagues that seemed to happen regularly in Australia suggests that after the food runs out they start eating each other. https://t.co/WBX6noVpYi
I think the answer to figuring this out is to track wild mice and try to monitor what they are eating. If we can reverse engineer their diet by measuring fecal mater, correlating it with food availability, and they forage, then maybe we can figure out what is causing cannibalism?
What am I meme'ing myself into?https://t.co/ReDYbKKIOL
Why am I looking up how to build a sealed environmentally controlled chamber for housing large amounts of mice in a basement?https://t.co/MjWhEfwqM8
Happy Rats?https://t.co/hFZSLqYyziMaybe your rats are dumb because you don't let them play.https://t.co/MkdKAIgCX8
"A new study systematically assesses cage enrichment and its effects on mouse welfare and experimental variability."https://t.co/iTDlfuupUW
So we isolate rodents — a poor surrogate for human serotonin, gut microbiota, brain structure, & microglia / immune system function — then test 'em by torturing & seeing how long they struggle.This is foundation of pharmaceutical science?Is that right? Am I missing something?
This weird idea of impregnating (fancy word for inserting) mice with human cells and testing them seem like some kind of perverse fetish scientists have to be able to study stuff. I'm so ready for humans-on-a-chip variations on personalized medicine.
"Replacement of these poorly predictive animal models with dynamic systems composed of human cells has the potential [...] to provide drugs that [may be] less likely to have deleterious effects on the patients for which they are destined"https://t.co/wALpoF2Dcx
Did you know that Feynman's observations on the weird junk science testing around mice mazes was probably because he was curious about multi-sensory integration in humans?https://t.co/u1P88jz0qN
I think I figured out human hibernation, but I need to see if I can induce it in mice first (without torturing them).Let's just say: TH17 and impact on neuroinflammation and neurodegeneration at intersection of immune system & diet is very interesting.https://t.co/U3LiQZsmkr
@Meaningness I've been operating under a mental model that some people are predisposed to a hibernation like syndrome that operates thru the immune system's response to sunlight. Stuff like your sun lamp or this new type of at cell falls out of my model trivially: https://t.co/CYFYmr7uMI
How do we measure 'torpor' in mice? asking for a friend.https://t.co/e2FoIJlAtn
This is interesting. I wonder if this shows up in mice too.https://t.co/WrXloQzpqShttps://t.co/Lhopif3PJv
Talk to me about Hydrogen Sulfide's impact on body temperature and mitochondrial function.https://t.co/ToepU3I5pf
Meme'ing myself into doing science.Giving my self the courage... and permission to try.https://t.co/h9lnbT8Yt0
Do nematodes hibernate? Yes https://t.co/QPEoDyK7VZDo we test nematodes with an intact natural microbiome? Probably nothttps://t.co/FayQxEBD7rAre we able to get nematodes to hibernate in the lab? Not surehttps://t.co/7r8YrmFHow
😎"to their surprise, that nematodes that were raised in a carefully controlled atmosphere with low concentrations of H2S (50 parts per million in room air) did not hibernate. Instead, [...] their life span increased and they became more tolerant to heat"https://t.co/lRVaia4FJ0
I heard that many hyper-social ants don't age. Now I am wondering if they fart out hydrogen sulfide from their gut microbes, or if they generate it from the fungus they grow.https://t.co/oP40EyFkC5https://t.co/tt79CFBKVR
I wonder what this bacteria does.https://t.co/CBndACrMiG
Oh wow, a paper from 1964 talks about how that bacteria (Streptomyces) which makes antimycins also produces hydrogen sulfide.https://t.co/qoxwwbqJPJI'm going to go eat the fiery heart of an ant nest.https://t.co/Q0fGHVR9Hx
"Ascend" kills fire ants. I wonder what it is doing.From '(Hymenoptera: Formicidae): An Historical Perspective of Treatment Programs and the Development of Chemical Baits for Control' [2001 american entomologist]https://t.co/6l1mmyKRU9 https://t.co/C27LZ8fzve
"rats also behaved quite unlike rodents that take part in typical studies for typical rewards. When conditioned with food, rats are usually silent and can tirelessly perform hundreds of trials. Reinhold’s rodents were eager to play"https://t.co/H2pFS2CHLthttps://t.co/fRGh68kAC5
I wonder how SSRIs impact playful rats.https://t.co/v143cqhlpO
Do ants or bees "Play"?How would you know if you weren't looking for it?https://t.co/n4AaVGVecF
Apparently this wasp's behavior is referenced in Godel Escher Bach? https://t.co/RXWIhtuT1QI wonder if humans have automatic behaviors like that.*tickles you*https://t.co/4s0zNx4KKz
Is nervous laughter as infectious as yawning?https://t.co/1e1loNmedDWhat of chortling rats and barking dogs?https://t.co/FJX6LDPgjQ
If rats chortles are too high pitched to hear, how would you know if mice yawns are audibly contagious (like dogs)?And if your captive rats don't play because you aren't raising them that way, how would you even begin to find out?Why does nobody seem to look for these things?
"but in general it was difficult to induce tickling in adult animals “unless they have been tickled abundantly when young.”"https://t.co/pjrAX4JniS
I wanna troll variations on rats to see if they experience envy.https://t.co/ziuaEUDSde
What does maniacal laughter sound like?Asking for a friend. 🤔https://t.co/R354V2CacT
1897 article talking about variations in human laughter.I wonder if laughter is culturally mediated.https://t.co/c79vzIdXoH
Whatever you do... Keep a straight face!https://t.co/wxksg0OYv7
oh no 😂https://t.co/1lz6rZb9W9
Do you ever go to bed musing about the practicality of building a box to keep your shit temperature controlled (for reasons), then wake up sweating, then start wondering if you can turn it into a coffin?https://t.co/v9PtJR3M0z
I wonder how this compares to IRL mouse habitats.Honestly, this looks like it would be fun to explore in VRhttps://t.co/oD5aMesJqk
Does anyone know of John W. Tukey experimented with any serotonin associated psycho-active drugs, or what time period (and where?) Feynman would have had the conversation he talks about here? https://t.co/ifjMHY9gG6
I suspect it would have been at Princeton when Feynman was there getting his Ph.d? but I can't collaborate it with anything.Trying to figure out if Feynman was experimenting w/ drugs while in college.Trying to cross ref Alcohol and LSD / John C. Lilly: https://t.co/cS25wR6yxt
Here Feynman is relating between mental conceptions of ideas and translating between different modes of sensory interpretation.https://t.co/C10xT3UtFhSomething at the 2 minute mark caught my attention.
Why was he stumbling?"I found that out because at-it-the-l [very early] lowest level... I won't go into the details but I got interested in.... well I was doing some experiments, and I was trying to figure out something about our time sense"
I'd bet money he was getting hung up on social taboo feelings around experimenting with drugs and causing him to stutter and then self-censor. Was he hiding information because of the context of the interview? Was he trying to avoid incriminating friends?https://t.co/rplfI91WRb
Peter N. Witt's experiments on giving spiders drugs happened roughly 1948. I'm trying to track down the memetic diaspora at time lead to it happening. I noted that John Tukey was previously a chemist.Shot in the dark; perhaps it's an echo of Christopher Kelk Ingold's work?
I make a joke. https://t.co/UiJPubjD2K
Who else should I research if I'm interested in multi-modal learning theory and sensory integration and synesthesia conditioned by experiences?https://t.co/2T3hlopev2
I think part of Feynman's particular genius was his awareness of how his own mind works compared to others. Perhaps a result of his curiosity directing his thinking inward. He found that people read differently. (and can perhaps respec?)https://t.co/Qf3PVEMTgU
I always find it weird how many SSRIs I find seem to have strange impacts on insulin and gut microbes.https://t.co/NUzMs5NAKc
Why do SSRIs impact sense of taste and smell?Why is do some pain killers impact inflammation and pain.Why does major depression seem to be about brain inflammation and cause chronic pain symptoms?So many questions.https://t.co/OQByWRQiL8
Is CBD acting as an antibiotic?Why do some people report antidepressant effects from ibprophen?Why does tylenol kill gut bacteria?What the fuck is acetylsalicylic acid doing to regulate pain?https://t.co/tF4Pfx5GFU
Antibiotics can cause depression?https://t.co/zdmq9pFKLYAntibiotics can cure depression?https://t.co/gxY0hmHGws🤪https://t.co/OD2CqMVn3p
How much can you infer from existing studies?https://t.co/FSVns8rPTa https://t.co/QtiNDjrlfs
I am spooked, myself.https://t.co/tPmZmszoB7
@JohnNosta @Forbes @mikeadams73 After a couple of months of exploring this idea and the mechanisms around both CBD and Tylenol's impact on the endocannabinoid system, I am avoiding both, and recommending others do the same under all cases except treatment resistant seizures.
Theory: CBD oil inhibits FAAH and allows natural endocannabinoid system to work as anti-inflammatory. Can get around needing CBD if I just up-regulate anandamide production by eating well.https://t.co/XoLNrF2sao
But if I am up-regulating anandamide, I ought to also ensure that my tesosterone and estrogen levels are matched. https://t.co/6t761yCSfqTo avoid possible feedback from lutinizing hormones.https://t.co/GeA2mlcfLVThankfully i'm not castrated.https://t.co/x6vRbxUpbK
But for me, deriving a model from current research is questionable. My cholesterol production is fucked, and I have tons of liver / CPY mutations, and that throws this whole system in disarray. At least I can generate enough of a model to make hypothesis.https://t.co/cgyFwrWEAA
my thinking: there's some complex thing going on where my body overcompensates for higher estrogen production by producing more testosterone. Or vice versa. so what I'm trying to do is regulate estrogen levels & hopes that it'll stop my testosterone from going out of control.
I love my twitter network. I suddenly remembered that there are weird things happening with serotonin and Multiple Sclerosis at the intersection of psychedelics research. Forte already dug thru @tferriss's stuff to find what I wanted!https://t.co/Rs9JkT521S
I'm not trying to reverse my brain issues and invent a Limitless pill. I have no idea what you're talking about.https://t.co/Nqf4cjNAV8
Oh yeah, experimenting with THC suggests I can use it to easily enter hyperfocus flow-state, with linalool helping to avoiding sensory issues that I normally hit upon.https://t.co/sVRnItq6qc
Whats really fun is finding someone who's already 3-5 years ahead of me in exploring TRP function and finding out that all my hunches on terpenes and endocannaboids are mostly correct.Linalool consistently resolves a pain/itch sensation from Flow State.https://t.co/19yDZ6lwIo
"On the contrary, long-term stress (chronic) impinges on reaching the flow state and disrupts the immunoprotective effects on various physiological functions (Dhabhar, 2014)."https://t.co/oKbHWYudNp
Stress impacts the immune system, you say?https://t.co/ggeEtBfYUI
I need to move out of this house. I need more control over my environment. This has been my priority. But it has been slow going. Ideas that are waiting for me to reify...https://t.co/bKV1TqiKdL
I can't wait till the sun comes back.https://t.co/bIluIXAN1r
What is psychological hibernation?"These variations can significantly influence parameters such as circadian rhythms, sleep, mood, and executive functions [...]These changes have typically been associated with decreased mood and cognitive impairment"https://t.co/0C0MuFTInD
"[In] absence of such clinical evidence, a citizen science movement has emerged where patients share their experiences with using different strains and products to treat a host of conditions. We can do better, provided restrictions on research are lifted."https://t.co/jszY61FISk
"I had made the mistaken but absolute assumption that: everybody realized that aging was by far the world's biggest problem, and therefore biologists would be working on it, and grinding away. [...]I found out I was wrong."https://t.co/bxYqTOg2QK
The "pro-aging trance" is induced in part as a way to sell cruise ships. A lot of our advertising plays into our fear of death and implicitly reinforces the existing meme.https://t.co/FtBUbXNMrt
Remember, your children are slowly aging; if you don't give in to their shill cries for Disney merch, they won't love you. As you lay on your death bed, don't you want to have your memories filled with their smiling faces, knowing you provided them joy?https://t.co/WYgg0IJBmG
I heard brains are pretty cool.https://t.co/c5eNwSTcjo
I read this "The brain was a cold, moist organ formed of sperm." and then wonder what he actually meant by this, and if I can find an actual quote to see if it might have been misinterpreted.https://t.co/Mv3xWz1wxe and also to see if he dissected any hibernating animals.
Them doctors and their depraved necromancy, trying to prevent death.https://t.co/K4xDDRbmAC
"This conceptual rearrangement represented a scientific revolution in thinking, a change in absolute perspective that required the reinterpretation of old data within a completely novel framework. "https://t.co/cvWMnNrU5W
“Ah you think T cells are your ally? You merely adopted the Thymus. I was born with it, molded by it. I didn't see the sun until I was already a man, by then cytokines was nothing to me but blinding!”https://t.co/alUgIFGgfdhttps://t.co/flGrpEWVjW
I get upset when people mention universe 25 and don't realize Calhoun's Rat parks kept going after the media hyped it up about Malthusian collapse.Don't get me started on Stanford prison or the milgram ones.I shit on your myths.https://t.co/5Boww1MS0F
EGCG (matcha), Zinc, Selenium (Oysters), Lemolene, Yerba Mate, Sapponins (Tereré), Lactic Acid based low lactose diary as source of cholesterol+fats (cheddar cheese)San's yerba mate, this is basically what I'm doing to reverse Multiple Sclerosis. 😇https://t.co/AuC8InPYzM
This works for ants. They really like pepper jelly.https://t.co/qpZlEqRvoP
I have a little tomten visiting my house. I can see their footprints in the snow. Funny how they follow the same path as the squirrelfriend I made in July.https://t.co/BKGTHJEEs1
Cool, lets to mosquito saliva next.You can see the research chain that lead to thishttps://t.co/eLbQaI3dnU [2002]https://t.co/fbd4CHxPFW [2009]https://t.co/14ddi12AuF [2019]https://t.co/FcozZfam1M
The problem? That we were studying this in mice.https://t.co/QgJwQ1zOUIWe literally have to gene edit mice to prevent Lyme transmission. A good example of how we need multiple animal models paired up with the real world to make advances in this space.https://t.co/5A52P4QSEQ https://t.co/nSmxm1Ojz2
There's talk about using gene-edited mice to help them fight against the transmission of lyme disease. The thinking is that lyme is being passed from tick-to-tick via their hosts, so if we can stop mice as a vector, it might reduce the spread.https://t.co/k5N2DFFIbb
Studying spotless germ free mice kept in questionably sterile conditions and prevented from eating their own feces like they do in the wild.https://t.co/tbVi1hzqDV
@EmLyWill @G_Protein Would be funny if saliva repels fleas that spread plague, but only if they have a certain oral microbiome.Seems plausible? https://t.co/AzGMUCBGbJ"Saint Roch in the Middle Ages was said to have been cured of a plague of sores by licking from his dog."https://t.co/gcjMy0ulpA
Watching gene edited mice lick themselves like they are the anxious 'pretty ones' in Calhoun's experiments. But they're gene edited/specially breed BALB/c mice whos immune systems don't support right kind of gut microbes to act as viable proxy for real world gut-immune interplay. https://t.co/QKjdM6Oh8t
If a mouse was covering itself in shit, do you think we would try to stop that? What happens if we prevent self-medication by restricting behaviors meant to help augment metabolic-immune axis driven by TRP pathways from chemicals in an animal's gut?https://t.co/FB6IbCSelf
Do you think mice moms eat baby mouse poop as a reverse transfaunation?https://t.co/WlzS7BzMGE
what happens to rodents that live in the dark who are cut off from eating each other's poop because they are raised isolated and without access to recylced microbial metabolites?https://t.co/OqZtahMuq9
Do you ever wonder why cannibalism occurs when Mormon crickets are starved, and if that is driven by shifts in their gut microbiota?https://t.co/jBoxFlzRwY
Would be funny if there are entire rodent labs who raise rats carefully because of cannibalism, but it turns out they just don't have the right microbes to eat carbs because they don't let them cycle feces like rats in the wild. https://t.co/eSGvIXNmYbhttps://t.co/i1AXYYKSJX
Emergent behaviors are tricky things to model.https://t.co/VGgZzZhfxR
"This adaptation by an insect to exploit a common metabolite produced by indigenous gut bacteria has wide implications for our appreciation of the role of the gut microbiota in insects." [2000]https://t.co/bEsvgfCNaQhttps://t.co/1wCZ5DNJ9q
My, what big brains you have.Why all the better to express an underlying epigenetic factors driven by gut bacteria, my dear.https://t.co/8irh7pKhA0
hehe"Infection suppresses bacteria responsible for instigating locust hordes"https://t.co/b017xXj923
"a role for gut-bacteria derived volatiles in the swarming phenomenon, and suggested that locusts are capable of manipulating their gut microbiome according to their density-dependent phases. Here, we directly tested this hypothesis for the first time."https://t.co/sBxrzYSsGc
Whelp."Yet another largely uninvestigated—but important—aspect of locust–microbe interactions, is that of the locust’s symbiosis with fungi and viruses." [2020]https://t.co/N6hj0c19P8https://t.co/0mlVNVQZhZ
Can't find what you aren't looking for.https://t.co/fM4EOh9eW9
So many mice fall out...https://t.co/YWSvPq0A6X
"suggest that nutritional composition of commercially available rodent diets impact gut microbiota profiles and fermentation patterns, with major implications for the reproducibility of results across laboratories. However, further studies are required..." https://t.co/9DBRZTRPCF
So many mice fall out...https://t.co/5gk0bgjDea