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Turns out @ mentioning somebody prevents me from removing them from my tweet storm, so I'm continuing this thread here. https://t.co/c6jzjbb799
Does acetaminophen reduce itch?https://t.co/fFjoHj5R2n
What the fuck even is acetaminophen?>One mechanism researchers have kicked around is that acetaminophen blocks cyclooxygenase (COX) enzymes. These help to form prostaglandins, which are pain- and inflammation-mediating signaling molecules.https://t.co/j13ulFRz4a
Thats... weird."Niacin-induced “Flush” Involves Release of Prostaglandin D2 from Mast Cells "https://t.co/72dLH03WEb
1973 called"itching in inflamed skin can also be explained by a pharmacological synergism in which low concentrations of prostaglandins, which do not themselves cause itching, potentiate itching due to histamine and possibly other agents."https://t.co/nHy5u06hoI
If an autistic person is more likely to report sensations of pain differently. What does a sensation of itch feel like to someone on the spectrum?> “Nociceptive” sensory neurons with small diameter nerve fibers are responsive to noxious stimuli.https://t.co/1aJAPUpXRn
I wonder if my skin mechanoreceptors grew funny for teh same reason why my whole left side went numb due to Multiple Sclerosis and cholesterol processing oddness.https://t.co/J3s0yQAK5i
I bet these don't work right in my skin.https://t.co/tn9SqaUFBR
Now... What kind of quantified self styled wearable would let me get a measure of how often I itch myself? I'd rather not have a camera watching me all day.https://t.co/VdYVMKBfbS
I wish we knew more about SSRIs and other serotonin regulation mechanisms impact stuff in OCD and itch. I think something is there that seems to coincide w/ my own biology. Sometimes I can't stop itching & thinking about them once surprised by an insect.https://t.co/7AgcbT91LS
Future me, after reviewing TRPV1, figure out what TRPM* is by comparison. You don't seem to have these committed to memory yet. They seem super important.https://t.co/oN0Gpp0Tf3
I'm going to go research the impact of diabetes on C tactile fibers.https://t.co/kiTZceIMRF
What if I told you that all of this research is promulgated on a hypothesis that I can cure my girlfriend's type 2 diabetes thru diet by using various terpenes to bias her microbiome... and all this about dicks is proxy research to hormone-microbe ties.https://t.co/zZ9obc2BGY
"Loss of sensation and increased sensory phenomena are major expressions of varieties of diabetic polyneuropathies needing improved assessments for clinical and research purposes." 🙄https://t.co/sNQqKNleGB
Fuck me."We showed in this study that children who used acetaminophen at age 12 to 18 months vs. those who did not were eight times more likely to have ASD"https://t.co/G9UyMZRkZM
huh"Our data support the belief that activated charcoal is more effective [at clearing acetaminophen] in the presence of [atropine based] anticholinergic activity."https://t.co/p29qKVqQ9e
Muh child had a fever after taking a vaccine, it's clearly the vaccines, and not pervasive advertising around Paracetamol that I gave to my child to cure the fever. /sAlso, what?https://t.co/GdjEGIJImA
I don't take anticholinergenics. If anything I've upreggulated choline in hopes that it would help my gut-brain axis operate more effectively.What the heck is going on? (and why do anticholinergenic meds help you sleep?)https://t.co/of489fhDxm
Thats... weird.https://t.co/e8Lj1wsfdK
Acetaminophen causes changes in touch sensation via TRPV1 receptors? wild.https://t.co/hDOHdtjNNq
"Our paper is also the first demonstration in humans that opioids affect how touch feels. In healthy individuals, blocking opioid binding tended to increase touch pleasantness, whereas in fibromyalgia patients it decreased perceived intensity."🤔🤔🤔https://t.co/IMnR9Zpb0o
haha."Spinal Endocannabinoids and CB1 Receptors Mediate C-Fiber–Induced Heterosynaptic Pain Sensitization"https://t.co/OwNqomQe8q
Is this why CBD oil helps me sleep and seems to be the only thing that improves my mom's Fibromyalgia Pain? Is it reducing some kind of inflammation factor and impacting skin irritability via TRPV1 pathways?https://t.co/t97UPMf480
"Among all tested variables, the affective touch awareness correlated with autistic traits only [...] Taken together, individuals with mental health issues have a lower baseline of expression and reception of affective touch."https://t.co/qhRscb57kV
I need to figure out a bunch of different painful stimuli I can do to myself at varying times / mental states. I wonder if painful electric shock (like ons used to test pain) can be variate to target individual tactile fibers.https://t.co/bN3GphP3g6
"Starting with the story of a girl whose sprained wrist turned into a nightmare, Elliot Krane talks about the complex mystery of chronic pain, and reviews the facts we're just learning about how it works and how to treat it."https://t.co/uFSYvdxV2F
I need to figure out more about @danariely's work in behavioral economics. IIRC he was studying pain (and placebo).Maybe I can test myself thru the same mechanisms, maybe via a wearable EEG and a device that hits pain receptors at random.
@danariely I wonder if weird way placebo and autism's strange sense of risk aversion/tolerance operate mean that some times I am immune to placebo, other times I am not.Does eating hot peppers reduce sensation of pain (via TRPV1) *AND* my reward for placebo / risk?https://t.co/WchlLiK0J9
I found a patent published this month about using a medical wearable to trigger Mechanoreceptor sensation.Makes me wonder what would happen if they weaponized it.https://t.co/xldkoSY7FK
I wanna figure out what causes feeling like stuff crawls all over my skin sometimes; so I can decondition it.🤓I may need to figure out ways to experimentally induce a sensation of stuff crawling over my skin.😭Maybe I can stop my mom's chronic pain?https://t.co/VprjrvXKCS
I just realized I can now afford to pay for my mom's 23andMe next month. I am going to cry.https://t.co/pNdlLZhJDF
I have nightmares of all the medicinal drugs she's tried over the years. Pain management is a clusterfuck of mismatched efficacy and lack of understanding.https://t.co/DGafFQIvPL
In a completely unrelated topic, here's a video about how the 'sound' of a gun changed the way that people perceived the effectiveness of a virtual weapon in a video game despite having exactly the same stats. And it *caused it* to be more effective.https://t.co/9ItYO0g5WC
Make the noob cannons go big boom,give noobs a psychological motivation to be get gooder-er.Scare many enemy!Get pumped. Psyche yourself.https://t.co/bK0YsPc0RO
'Interference of TRPV1 function altered the susceptibility of PTZ-induced seizures'https://t.co/HFvfYxg43p'Dampened neural activity and abolition of epileptic-like activity in cortical slices by active ingredients of spices'https://t.co/crsL7z0SWx
'Capsaicin prevents kainic acid-induced epileptogenesis in mice.'https://t.co/j42UamWlLl
'Cannabinoids Desensitize Capsaicin and Mustard Oil Responses in Sensory Neurons via TRPA1 Activation'https://t.co/cMQBx4ixFo'Systematic review of topical capsaicin for the treatment of chronic pain'https://t.co/SoecbEuyB2https://t.co/9UQT9gdaJM
'Serotonin Increases the Functional Activity of Capsaicin-Sensitive Rat Trigeminal Nociceptors via Peripheral Serotonin Receptors'https://t.co/GuuU5jEm4W
'Dietary Capsaicin Improves Glucose Homeostasis and Alters the Gut Microbiota in Obese Diabetic ob/ob Mice'https://t.co/g7Rm07qXYB
'A 12-week intervention with nonivamide, a TRPV1 agonist, prevents a dietary-induced body fat gain and increases peripheral serotonin in moderately overweight subjects.'https://t.co/yH4jid0qXG
'TRPV1 (vanilloid receptor, capsaicin receptor) agonists and antagonists'https://t.co/njBW0jPoi2
"Confusion exists in the medical literature secondary to a failure to recognize chronic marijuana use as a source of vomiting. [...] two recently published series of adult patients with CVS, approximately one third of patients reported daily marijuana use"https://t.co/7LVDlDqEsS
"Cannabinoid hyperemesis syndrome (CHS) is characterized by symptoms of cyclic abdominal pain, nausea, and vomiting in the setting of prolonged cannabis use. The transient receptor potential vanilloid 1 (TRPV1) receptor may be involved in this syndrome."https://t.co/89pcXoXsni
'Are itch and scratching the nausea and vomiting of skin?'https://t.co/AppFYrLcWP
'Itch: Mechanisms and Treatment. Chapter 6 Pruritus of Cholestasis'"The effect of lidocaine on the pruritus of cholestasis may be related to the role of transient receptor potential vanilloid receptor-1 in the transmission of the itch sensation."https://t.co/8NCKOFyYrk
NSAIDs and microbes interplay.Who could have guessed that things that impact fever change the microbes, and they fight back?https://t.co/zBy8vRhEAC
Nausea.Pica-chew."When mice are in either acute or chronic pain, they may start to engage in pica-behaviour, which is defined as eating bedding material or other strange, non-food objects"https://t.co/dSFJ8u4PI8https://t.co/bqr3FigdeP
I lost my vomit reflex + nausea. Its back now. It's been back partially since I fixed my serotonin thru diet, and came back entirely after my gut-reset fast.Why do autistic kids exhibit Pica?is it common when they are in chronic pain?is it downstream of TRPV1 and vagus nerve?
Why doe some people vomit when they run?What even is anandamide?https://t.co/bIISkv8bNo
Serum anandamide is low in autism, adhd, (elevated in acute schizophrenia)https://t.co/Rv7ThtbzOi
Looking up alcohol's impact on short and long term memory. How CB1 & CB2 receptors + way the Cannabinoid system is impinged upon by the gut.https://t.co/Z0Fpy2SwIjDoes runner's high improve long term memory?Is Anandamide partly why walking improves cognition in adhd?
Anandamide produced via omega fatty acids.Improvement in adhd symptoms only happens in individuals low in omegas.https://t.co/nzyG6lj46DI wonder why.
There is weird stuff here. Weird stuff . It's almost like eating fats and sugars together causes some kind of immune response leading to gut dysbiosis and poor fatty acid management, leading to brain development oddness in utero.https://t.co/IEKpzaYNKM
Like some kind of neruoinflammatory disorder driven by diet leads to autism.https://t.co/xylqQpYlc7Murkyhttps://t.co/jtMHE8pZ7h
I see pain everywhere now."Little research has been done on this topic, but the very behaviors interpreted as a high tolerance to pain — such as head-banging or hand-biting — might be signs that the individual is in agony."https://t.co/mXXS1TAXnO
When the pain stops in my gut, I can start to feel externally.To sense the world and engage with it. To communicate with it.The *pain*ic goes away.https://t.co/my3XG3i9CE
One might call this an... Oral fixation?https://t.co/86xHFg71Nt
Chewing gum seems to improve anxiety symptoms and mental function for those with adhd. I'm looking at buying a chew toy for myself.What is haloperidol doing?https://t.co/xeNnhxU5uk
Anadamide impacts neuronal cell death. If It's low in autism, could that explain hyper connectivity?https://t.co/AYrhPKYN8mAnadamide impacts sleep in an interesting way.Could being low be why sleep troubles are common in autism?https://t.co/9bvYq9lrRmhttps://t.co/bVCKxberb3
Does being in a flow state mean that my brain cells are accumulating toxins and make me have to sleep more?https://t.co/6RqC6H7L2lDoes autism's sleep associated brain wave issues mean my brain isn't reaping memories.Is why I seem to remember too much?https://t.co/xllVfueDwC
So many weird ideas around TRPV1, CB1, CB2 and Endocannabinoid. Half tempted to just get a medical cannabis card so I can experiment on myself.https://t.co/V9UWmecEEi
Huge implications if we frame this against serotonin -> vagus nerve -> Oxytocin expression that shows up in L. Reuteri Studies (assoc. with autism).Why does a bio-available Cayenne concentrate give me my voice back during sensory associated a meltdowns? #trpv1 #actuallyautistic https://t.co/Fnbf0IeLJE
I know how to boost AEA (run + eat precursors).How do I affect 2-AG?https://t.co/qwcwpNi9uS
I have to understand TRP pathways.https://t.co/UXzHqeGDPU
@MicroBerto AEA also binds to TRPV1, which is equally weird in rodents as it relates to their their body temperature. Antagonism of TRPV1 makes them hypothermic https://t.co/7m8b7xr1MVwhere as in humans it seems to be the reverse.https://t.co/kLib0JUxgzStill trying to figure out why.
If I just let myself get sick for a few months, I can trigger an MS flair up and then plausably get an offical diagnosis. This would let me try out this fancy spray that just got FDA approval.https://t.co/0JPYELU6RP
> It is noteworthy that in some cases, particularly concerning multiple sclerosis and HD clinical studies, CBD per se does not seem to be beneficial. However, when CBD is administered with Δ9-THC in a 1:1 ratio, therapeutic effects are observed. https://t.co/i7IzfCuD9WWhelp. https://t.co/RTvz6tKDT4
Fatty acid amide hydrolase mutation immunizes a woman from pain and anxiety.https://t.co/CbWleWQdXo"That's not good at all, is it?"https://t.co/iwjNrNKid7
"The University of British Columbia recently published a study indicating that certain over-the-counter painkillers, like Tylenol, can be taken to relieve anxiety."https://t.co/1AUQ3N56g3
"administering cannabinoids with a high-fat meal or in lipid-based formulations has the potential to be a therapeutic approach to improve the treatment of MS, or indeed other autoimmune disorders."https://t.co/myeG0N5EMYTL;DR: Sativex as spray is joke. https://t.co/ZbqORcBRrX
Runners diarrhea?: High levels Anandamide maybe inhibits TRPV1 and locks down the intestinal barrier - leading to poor absorption and a response in intestinal motility driven thru 'itch' sensations?https://t.co/EHqsKDa6aX
"TRPV1 becomes rapidly desensitized upon activation, rendering the channel refractory to further stimulation."https://t.co/h779QWLU3e"[anandamide] is a [poor] TRPV1 agonist that behaves as a partial agonist in tissues with a low receptor reserve" https://t.co/HWzKdCGBP2
What kind of itch?https://t.co/0D4iARf1IG
The kind of itch that makes it so mice don't vomit up poison.https://t.co/bqr3FigdeP
Sprouting cannabis seeds by soaking them in water would be the way to maximize CBG content. https://t.co/k59ksw1mQJAnd CBG? well... let me tell you about "pain that prevents movement".https://t.co/Kg0btwGha3 https://t.co/Q4BUlz6Jom
@MeFromBefore I ate some CBG a while back and it seemed to have changed my TRPV1 receptors because I couldn't taste any capsaicin, or even feel pain.Been trying to figure out what drives tolerance in hopes I'll figure out how to stop my mom's chronic pain disorder.
I'm not allowed to help my mom with her chronic pain disorder or they'll make her go homeless.https://t.co/3gpbWddoM8
"We also focus on the overlap in mechanisms whereby commensal gut microbiota and endocannabinoid ligands can regulate inflammation and further aim to exploit our understanding of their role in microbiota-gut-brain axis communication in pain processing."https://t.co/u4H1GunjKH
There is something interesting here.https://t.co/WX8uEt6t71
Great exploration of the role of ion channels (& TRP receptors) and their impact of metabolic function, with a slant on the impact of circadian rhythm factors. https://t.co/fpgNpjGsgdWill need to find the book if I can.looks like curcumin hits TRPM2https://t.co/9aUAKGYYcF https://t.co/EDuFl5u2MF
Timely to have that insight as I've been digging back into mTOR / adrenaline in fatigue lately.https://t.co/xoNvMbWoEm