🧵 View Thread
🧵 Thread (28 tweets)
@JimmyRis @InquilineKea @The_Lagrangian A surface look at it suggests it's action on Schistosoma (a flatworm / helmith) is in line with what we see in tumeric: https://t.co/lupazBNGMg and is comparable to other anit-helmith meds https://t.co/WQMQSvaGyAA hunch: Tumeric's anti-tumor effects act on similar pathways?
@JimmyRis @InquilineKea @The_Lagrangian med is also used in fisheries along w/ cod-liver oil. I wonder if anti-inflammatory properties of oil help with removing of the parasites. https://t.co/4Gw8dGrlG8Been trying to track a trend of kind of thing https://t.co/Lp5fbvC8nH ala Ayurvedic; looks like anti-parasite stuff.
@JimmyRis @InquilineKea @The_Lagrangian Related: that flatworm's widespread immune system deregulation seems to cause a bunch of strange cancers https://t.co/b00iExmxAS
@JimmyRis @InquilineKea @The_Lagrangian Weird connection: Males have higher parasite burden https://t.co/Ss8QZgvjSXAnd seeing this earlier today: https://t.co/5GyvbPS3PJ
@JimmyRis @InquilineKea @The_Lagrangian So... whats going on here?"This is a major finding — bladder cancer development and spread to other organs depends significantly on CD24, which in turn depends on androgens like testosterone."https://t.co/xyDADKrDiN
@JimmyRis @InquilineKea @The_Lagrangian Exploring further, that drug may have strong impacts on cytochrome processes in the liver based on this study in pigs https://t.co/5VGukT1gwb and may have adverse impacts during pregnancy https://t.co/RrSJJPw3Tx
@ultimape @InquilineKea @The_Lagrangian https://t.co/zxOfDTnJWl This is interesting, I didn't know about: tumors aren't so great as vascularizing themselves so they end ⬆️ with hypoxic zones of cells, and these areas of hypoxia are radiation resistant.
@ultimape @InquilineKea @The_Lagrangian Yeah, hypoxic areas stick around thru radiation treatment and revive the tumor. Some popular cancer meds effect the mechanism by which radiation damages the tumor cell DNA to make radiation more effective on hypoxic cells (though that paper says they didn't see this with fenben)
@ultimape @InquilineKea @The_Lagrangian "Because molecular oxygen is a potent chemical radiosensitizer (4-6, 20), hypoxic tumor cells are resistant to radiation, can survive radiation regimens that would eradicate fully aerobic cell populations, and can cause tumors to recur after radiation therapy."
@ultimape @InquilineKea @The_Lagrangian "Intensive efforts inour laboratory and many others, have therefore been devoted to improving the outcome of radiation therapy by combining radiation with drugs that improve tumor oxygenation, selectively sensitize hypoxic cells to radiation, or preferentially kill hypoxic cells"
@JimmyRis @InquilineKea @The_Lagrangian So if its not impacting radiation therapy via oxygen (c/f "oxygen is a potent chemical radiosensitizer"), then that would suggest another possible avenue is affecting metabolic properties of cancer cells and their ability to grow/eat? Nice.
@JimmyRis @InquilineKea @The_Lagrangian Inflammation -> white adipose recruiting -> supply of food."the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration."https://t.co/uEpudPgMFO
@JimmyRis @InquilineKea @The_Lagrangian I also wonder if some parasites use a similar process:"This finding led them to drill down and look at the matter in more detail. Were cancer cells themselves making their own fats? Or were they importing them from the nearby adipocytes (fat cells)?" https://t.co/s7SbQvVlWU
@JimmyRis @InquilineKea @The_Lagrangian afaict this is new idea."Recently several studies have clearly demonstrated that the white adipose tissue is a true endocrine organ, a secretory organ metabolically active, and far from being inert tissue "https://t.co/ulImH9OuA6
@JimmyRis @InquilineKea @The_Lagrangian but not entirely newhttps://t.co/S21IdFCgBk
@JimmyRis @InquilineKea @The_Lagrangian That space has lots of weird links into my main focus -> immune system shifts and it's impact on autism/brain development. https://t.co/AybDFiOMNg
@JimmyRis @InquilineKea @The_Lagrangian huh, maybe it's operating via Glycoconjugates and N-Acetylgalactosamine / oligosaccharides (energy production pathways)https://t.co/eXoFFXNKMH (references https://t.co/uMQchqu9pJ )I saw while exploring oligosaccharides & diabetes type II ala Curcumin: https://t.co/OKpwS81BCv https://t.co/mh3ctznLXb
@JimmyRis @InquilineKea @The_Lagrangian I made a thread on garlic that dives into a medieval antibiotic mixture meant to fight eye infection. Turns out it works great.https://t.co/ONcOELrbzi
"When we built this recipe in the lab I didn't really expect it to actually do anything. [...] it could actually disrupt and kill cells in S. aureus biofilms, I was genuinely amazed."https://t.co/AayajO0PuUWhat a wonderful username "@friendlymicrobe" :Dhttps://t.co/VnBbWoVk07