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Mifepristone has an impact on the immune system in how it causes abortion and a rare rare rare cases can cause septic shock. I wonder if having the wrong vaginal microbiome could lead to that? Seems to be similar to toxic shock syndrome ala tampons.https://t.co/KetC9oOhH2
Huh, it seems to help with arthritis in dogs.https://t.co/KKuNxLzCw2
The action seems to be via an overgrowth of C. sordellii. Would suggest that there might be a pre/probiotic combination that would help make Mifepristone safer. Still it seems to be such an extremely low risk I don't think anybody would bother researching it.
I'm mostly putting these notes here so that I can remind myself to research 'cramps' and how Mifepristone acts on smooth muscle tissue in the uterus. I wanna see if there are natural herbs that act on the same chemical pathways. I wonder if True Blood's abortion arc was real?
Note to self: Cimicifuga racemosa (Black Cohosh Root) also causes cramps.https://t.co/MHI0t216Og
Neat! I'll have to dig up these studies."Preliminary studies suggest that black cohosh may help reduce inflammation associated osteoarthritis and rheumatoid arthritis."https://t.co/Vkxwmc0fOS
"The causes of many of these diseases, which occur more frequently in women than in men, are not clear." <- the idea stuck in my head today after reading: https://t.co/0Uquo4OSyw
does it help w/ schizophrenia?"Black cohosh seems to be modulatory of the visual cortex, but I have to find a dopaminergic modulator. When I take risperdal and black cohosh together, I experience a very visual fluid trip that is unlike any psychedelic."https://t.co/xJxwjBkVU0
Oh neat, given it's likely operating on smooth muscles, of course it acts as an anti-hypertension agent.https://t.co/1g75FFNFqs
Tangential:https://t.co/KBZkAI87Xd
Weirdness"Several studies have shown that, direct and indirect evidence exist on increased testosterone in Toxoplasma infected human and animals [35–39]"https://t.co/QYr2b5p84u
T gondii likely impact mice thru immune system changes. This is basically my model of how it affect testosterone levels in humans. https://t.co/Kp2t7Qlnmh
But the larger idea is that humans have a tweakable immune system.I wonder if human's sense of smell operates on a similar system as mice.https://t.co/1L9KxxYj5Q
Can shame and social stress alone cause a women to auto-abort?https://t.co/cDCG45nDaj
"immune system affects -- and even controls -- social behavior, a new study has found. [...] The discovery could have enormous implications for neurological conditions such as autism and schizophrenia."https://t.co/6kbt7INyY8My dog butt theory of autism strike again. Shocking.
social stress -> immune system -> social behavior. This is a feedback loop.Mmm butyrate. https://t.co/VAkuyH8Cq9
White matter in the brain.https://t.co/y9nkey24QA
Huh, could it be Saponins (from the root) causing the these effects by down regulating certain infectious agents?https://t.co/fuFsTY3rH2
Saponins (from gensing) may be the reason why it helps with atherosclerosis, by acting on smooth muscle tissue in an interesting way.https://t.co/YhzoEOve9a
Hmm. Now that is interesting. How?"In a small study, patients had fewer negative symptoms -- such as lack of motivation and a severe reduction in emotional expression known as "flat affect" -- when they took Panax ginseng than when they took a placebo."https://t.co/01DnGU8psn
hehe, taking gensing and st. john's wort can cause mania/psychosis as much as it can help it. Suggests it's regulating something in one case, disrupting it in another.https://t.co/HliVgry0N8
Possibly related: https://t.co/icowAT4iDF
@KikiSchirr Interestingly, St John's Wort can mess with birth control effectiveness too b/c it changes liver metabolism of Progesterone etc. https://t.co/kRXrYgm7PNDon't know the full picture (genes, microbiome?), but it seems related to Nonalcoholic fatty liver disease in schizophrenia.
"pointed out that the patients with schizophrenia and those with bipolar illness were being dumped into the neighborhoods, many of them becoming homeless, or victims of assaults or of suicides, or found themselves in jails." :(https://t.co/I3JkGBhk0e https://t.co/EXO8vS0Fwm
"Although it has been suggested that P. ginseng may have beneficial effects in the treatment of ASD patients in a preliminary study with human patients , no definite and elaborate study has been conducted in either animal and human studies." why?https://t.co/cBotrLRrxw
Did you know that institutionalized schizophrenic women would have their uterus removed b/c birth control doesn't work for that population - if anything with higher levels of diabetic/pcos issues, the pill can actually improve fertility.Pregnancy is hellhttps://t.co/WZrBebIFxI
Is anyone making Mifepristone via DIY bio? Please keybase message me if you know."identifying lifesaving, costly drugs that can (at least theoretically) be recreated in a canning-jar reactor."https://t.co/GaxPXh0vNS
"Massachusetts prosecuted a woman in 2007 under a state law that says it is a felony to procure your own miscarriage. [...] The wording of the laws differs in every state and not every state has laws on the books that explicitly criminalize this practice."https://t.co/KKuNxLzCw2
"Many folks take it for general good health and for added vim and vigor. Try it for yourself! [...] Do not take while pregnant or breastfeeding" 🤔https://t.co/RWYZ4t58Ij
"Black cohosh has a history of traditional use among Native Americans for the treatment of a variety of disorders, including various conditions unique to women such as amenorrhea and menopause." and might be an effective Galactagogue?https://t.co/BqmIkr2lTf
Everything here seems to be related to smooth muscle tissue, from the effects on hot flashes to even the side effects of headaches and upset stomach.https://t.co/13aAadP1Dv
Tired: plant based terpenes as natural detergentWired: plant based terpenes to heal your skinHired: plant based terpenes to repel mosquitoesInspired: plant based detergents to assist the growth of a mosquito killing skin fungal microbiome. https://t.co/fG8uvcW9Fk
Wow!"Vermont has perhaps gone further than any other state to codify protections for abortion rights. [...] were to overturn Roe, the bill would prevent a governor or a local government from limiting access to abortions through regulation or other means."https://t.co/P771tmBbO3
Fascinating that there are "trigger laws". Is this a new thing, or something that states have done in the past to protect against drastic rule change? The idea of state level trigger mechanisms being used as a signaling is interesting too.https://t.co/1eAxtmCXDQ
Why does black cohosh do this? It is so weird.https://t.co/3w3kb78iW8
I wonder if this is similar to how we see Spironolactone (a hormone therapy) having an improvement on various issues in schizophrenia/autism.https://t.co/yxA2vQ3mfh
What if what we're seeing wrt memory performance variations among sub populations (associated with estrogen, body temp) is actually an artifact of bloodflow differences in the brain?https://t.co/0k41cWwikQ
Going to have to dig into that study on mental performance and temperature re:women and see if there is a similar correlation that shows up ala blood pressure.https://t.co/19mKVSYZx8
One thing that stood out on a cursory reading of the office temp study was that logic ability didn't decline. With my own memory and cognitive issues, I've often had to depend on logic and reason alone at times because my memory itself was so poorly.
Memory issues due to temperature effects would also explain math performance differences. At least I think it would affect the kind of math they were testing in the study. https://t.co/dUQNf3MoKf
Would be wild if sex differences in memory were all regulated by smooth muscle tissues. https://t.co/C0okv6gE38
If I had a uterus, i'd be considering trying to induce an fake abortion in myself right now (aka premature menstrual cycle) using smooth muscle tweaking stuff.Sadly, I only have a penis, and can only measure erection turgidity.https://t.co/Ty1WwVDqHV
The cruelest trick the devil ever played was convincing people that the answer to their problems is praying to a centralized authority in hopes that they will bless them with better laws.https://t.co/7P3WEHGImX
"Dose-dependent effects of antipsychotics on efficacy and adverse effects in schizophrenia[...] further investigations with larger sample sizes and more robust study designs that focus on each antipsychotic agent are needed." [March 26 2021]https://t.co/E8xp447503
>"Black cohosh does not appear to be inherently hepatotoxic, and the clinical features of cases suggest that the liver injury is an idiosyncratic reaction which may be immunologically mediated."https://t.co/mry3BklKrH
Fetor Hepaticus (a sort of liver disease/failure symptom) can be caused by "portal hypertension". Basically the blood doesn't get into the liver to be filtered.Why would black cohosh, a drug that impacts blood vessels, cause liver problems in rare case?We may never know.
"Here, we review the conflicting effects of estrogen on vascular smooth muscle cells, mainly proliferation and migration as two cellular capacities intimately related to physiology and pathophysiology of the cardiovascular system." https://t.co/9hvBdACCqK
I should stop taking the herbs that preserve estrogen for a while so I don't accidentally my liver."These results suggest that spironolactone acts on slow calcium channels in a manner similar to that of calcium blockers." https://t.co/tuRpahicjOhttps://t.co/Gn4hn4RBum
Writing a grant proposal to work on building a DIY sperm tracking tool to help aid with fertility concerns. And I never want to have children.Life is absurd.https://t.co/NS7R6OiiEi
This whole space is full of fucked ideas. Stuff that is used to help induce abortions is also super important for having a healthy pregnancy. If you're against abortion medications, you're likely unknowingly against medications that help women have successful births. Its absurd.
Did you know that sperm move a lot like ants? I'm going to build a tiny tiny ant farm.https://t.co/BwrFy1s588
I am soon to have documented proof that I likely cured my GF's PCOS - one of the leading causes of infertility in women in western nations.https://t.co/R4J4xHjTjD
I wanted to alleviate autism associated problems in myself. All of these discoveries I'm making are a result of trying to do that.https://t.co/soLKlQl8xk
@pmarca @sbaroncohen I have PCOS genes and estrogen resistance genes. And so while I present and was assigned male at birth, I have immune disorders that seem to show up in females in 5:1 ratios.It is said women get IBS more than men, but we ignore autism's GI issue rates.https://t.co/YaaBF9GNIR
Sometimes a willingness to lean into the taboo and explore things that others find disgusting, is the only way to make progress.https://t.co/GOlBOmVZ1g
Like making a connection between drinking semenhttps://t.co/GaXJXIsFrx
And wanting to become like alchemists of old.https://t.co/1QyoIlzJAt
@enkiv2 @sirsfurther One of the stranger implications of this is that the alchemical symbol for urine might actually be semen and the same mistranslation may have occurred. Apparently Newton used gallons of horse urine in quest for life giving water."life giving water" makes more sense as semen.
"The study of sexual physiology [...] has been going on for centuries, behind the closed doors of laboratories, brothels, Alfred Kinsey's attic, and, more recently, MRI centers, pig farms, and sex-toy R&D labs." https://t.co/qoV6XP8mgDhttps://t.co/IpxuC1rusz
This is weird. If states aren't allowed to go against FDA stances on drug safety, then that means they could just declare something unsafe and we'd be stuck with it being illegal too.What gives them this power?https://t.co/O3XkWeKixT
Something no one is really looking at is the strange changes in cortisol levels that Mifepristone induces, and it's secondary impact on BDNF. https://t.co/22S7EXFXbsCortisol is a major signaling molecule used by gut bacteria, is this effect actually a shift in gut populations?
I can only find speculations on what it's doing to mood."lack of correlation between cortisol and depression could represent hypersuppression of the hypothalamic-pituitary-adrenal (HPA) axis or insufficient mifepristone dose to alter HPA axis activity." https://t.co/ZU6y3vE9Hf
Def seems to have some pretty impressive action against pathogens, both in a negative way https://t.co/9oxo6EityHBut also possibly positive shifts in gut, with notable destruction of C. Diff and related. https://t.co/GNEQvwciQYhttps://t.co/HqlhhGMFWsSo what is it doing?
There are way worse drugs out there in terms of pregnancy complications and immune disruption FWIW https://t.co/LQvoAueynY
Has anyone taken gut bacteria from a pregnant women and inserted it into a mouse? I am looking up Couvade Syndrome + Phantom Pregnancy. The entire thing reeks of gut-brain axis impacts.https://t.co/ASCJAEH5TG
This is fascinating. @Evolving_Moloch's description of a traditional Covade Syndrome related behaviors mirrors what I would expect behavior to be if you wished to avoid pollution a child's gut microbes from cross contamination.https://t.co/we2onsyDJThttps://t.co/GrdY75ZwkJ
The weird umbilical rituals also align indirectly with interesting aspects of childbirth and stress hormones.https://t.co/hLcuAG0PQN
What I am seeing here are shifts in pregnancy mirroring weird findings around hibernation in animals.https://t.co/KYrhkOb4bm
If there are shifts in hibernation that mirror shifts in pregnancy, it may explain the weird feeding behavior shifts that would be a sort of accidental contamination into the father. Many interesting secondary implications.https://t.co/qeC4zpCuw3
"suggest a pathway of communication between certain gut bacteria and brain metabolites, by way of a compound in the blood known as cortisol. And unexpectedly, the finding provides a potential mechanism to explain the characteristics of autism."https://t.co/kkgs12NwRN
"It seems that pregnancy enhances that adaptation even further, allowing bears to become even more efficient at recycling waste to preserve protein and prevent accumulation of metabolic “trash.”" https://t.co/trJbRalT4M
What... happens if you drink your pregnant wife's breast milk to promote healthy lactation?https://t.co/2pTW4FcSN5
Pregnant mammal's immune system changes, microbes migrate to breast tissue and vaginal area to prepare for transfer and milk production to offspring. Disease that causes respiratory infection due to immune response leaves scientists puzzled.https://t.co/5YVk64ePd9 https://t.co/wnhIczD1CS
Lots of weird things going on in breast milk that could have an impact on the husband's gut biome. https://t.co/LlE8NajnAk
Did you know breast milk contains butyrate and melatonin on top of the prebiotic colostrum? It varies thru the day too.Works well to feed bacteria & calm the child's immune system during the first few months of their life when their natural antibody system hasn't bootstrapped.
Dogs may be getting cross contamination too, driving behavior changes."Some dogs become more protective of their owners during pregnancy and will stay close by your side. As your baby bump grows, this protective drive may even increase."https://t.co/EdN5lEZnQr
Psychosomatic: my ass.https://t.co/nrAJ8Ipfei
I bet not."The technique of temple sleep—a forerunner of the modern treatment of psychosomatic ailments—has been likened to present‐day “symptom removal,” [...] is achieved by “leaking through to the patient's subconscious the suggestion of healing.”" https://t.co/gxmUF5wanK
*in a very pompous early 1900s aristocratic voice*Well you see, the father ingests the soul of the mother and takes on her spirit, thus creating a sympathetic resonance with the energy of pregnancy. Every school boy knows this is what is occurring.https://t.co/9D4sBdLTmD
@kerry62189 @visakanv It fun how close these symptoms are to gut dysbiosis from stress resulting in poor production of important neurochemicals that impact the ability to think.The argument about it being 'body or soul' still exists today, with people arguing if its psychosomatic or something else.
"We show that pregnancy-induced changes in the female gut microbiota occur immediately at the onset of pregnancy, are vulnerable to modulation by diet, but are not dependent upon increases in maternal weight gain during pregnancy." [in mice]https://t.co/K4KqDnAZxG
This doesn't explain the phantom baby kicks directly. But gut shifts may be driving *really weird* behaviors and many of them could be psychosis-adjacent, may be rare or dependent on what bacteria are upregulated / food during pregnancy. https://t.co/dWOLQ9NSXw
We should be able to see phantom kicks showing up on the touch centers of the brain on brain scanning machines, similar to how people with emotion-touch synesthesia have an effect here (or like when some schizophrenics describe being touched by angels). https://t.co/LJEZ3MJXGr https://t.co/Ah1qkIlErl
Yes, I am saying that gut bacteria shifts during pregnancy are diving acute schizophrenic states in some people depending on dietary issues and immune state changes.https://t.co/sngivMUskC
"transplanting a totally new human gut microbiota in one shot, which is referred to as FMT, is likely to strongly improve the efficacy of microbiota-orientated treatments in MD and schizophrenia and maintain the effect over time." ¯\_(ツ)_/¯ https://t.co/Ged7u2Twxj
If I'm right, the herbal stuff that treats negative symptoms of schizophrenia are acting to cause abortions because they are acting on the same pathway: the gut.https://t.co/ATh5uxRu8c
@eigenrobot @Vahn16 @Shannon_Liao I have a bottle of herbal stuff in my fridge that helps with blood flow in the brain related to trying to find ways to prevent negative symptoms in schizophrenia. I found them because they help with menopause, and help me by impacting smooth muscle tissue in brain blood vessels.
If a pregnant person's immune system and gut bacteria shift quickly like seen in a rat, there ought to be a near term shift in the scent of the chemicals being extruded by sweat.https://t.co/AwkP3iz0Yp
"Even in the very early days of pregnancy — sometimes before you even know you’re expecting — your body is busy changing to help nourish your developing baby. Many of these changes can bring on side effects that might surprise you." https://t.co/Y7mwuiqYL6
"You’re likely going to smell and taste different — so heads up when your significant other is down under. That taste may be more “metallic or salty,” according to The Journal of Perinatal EducationTrusted Source."https://t.co/9rCXlaRgGO
"first direct demonstration that pregnancy is detectable via scent [...] important in cooperative breeders as, in addition to the competition [for mates], there is also intense competition between females for access to alloparental care." [2017] https://t.co/aq3FZpl7FP
New book on my Wishlist. Talks about doctors using something akin to plague masks to help thwart airborne infection risk from patients."The Scented ApeThe Biology and Culture of Human Odour"https://t.co/E6PyM1GWEk https://t.co/mlxdZnLHJV
Can learn a lot about someone if you sense of smell is well honed.https://t.co/YAwYR2puyO
Found it. Its a different image too? That's what threw me off.looks like the URL doesn't show up in search because one is /sv/ and one is /en/For future me when I try this search again: Semen Vagina Peaches Smell Taste Study Article Scent.https://t.co/jfh4NDJ02d https://t.co/cb32eplSb4
I think about smell and fertility-associated-health-factors a lot more than any healthy person should.https://t.co/UywOJZfRTR
Patents w/ threatening aura."(systems and methods for environment sensing) would be an array of ionic liquid sensors that could actually detect smells. A machine learning algorithm could help the device learn to distinguish between different smells." https://t.co/DVCe8MDd1a
I think it would be neat to be such a good midwife that I can smell when someone is pregnant before they know it and recommend ways to help them in whatever they choose to do.https://t.co/tSuu7Nr79i
"Our study is the first to show that the odour of peri-partum women may lead to upregulation of men’s interest in infants." [2019]https://t.co/i4L42wlngENeat.