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I wonder if acetaminophen impacts rat social responses.https://t.co/DMIb4yPN0l
A larger study came out recently that seems to be on the method of action for the Acetaminophen leading to less response to seeing the pain of others. You'll note that it impacts the anterior insula and anterior cingulate.https://t.co/p3PBnuKgBG
"Considering that anterior insula connects to amygdala, it is also noteworthy that amygdalar volumes are enlarged among pre-adolescent children with ASD"https://t.co/icFicbZLso which cites
a commonly referenced article "Amaral & Corbett 2003"https://t.co/kJYHqRB8i6
Which has been referenced in both a socio-cultural contexthttps://t.co/gLIw73oadI
as well as part of a reinforcement of a critique of Baron-Cohen's theories:https://t.co/JaROPIg1Rs https://t.co/iSdJg62ypV
I don't remember reading the amygdala theory of autism. But if it's an issue of connectivity between the anterior insular and the amygdala... I would expect such a theory to manifest in 1990s.https://t.co/KZ0utR2RWA
Its almost like... almost like we might be dealing with an overactive social response?https://t.co/gkA3NTppXX
"Meditation-induced reductions in pain intensity ratings were associated with increased activity in the anterior cingulate cortex and anterior insula"https://t.co/ZI1ryVDMx0but how exactly?https://t.co/LYDGFlWtDX
"The results show increased activations of the anterior insula (AI) and anterior cingulate cortex (ACC) as well as the medial prefrontal cortex and temporal pole when sharing others' social suffering, both in LTM practitioners and controls."https://t.co/RmS6lWQbx1
Now all that junk about mindfulness meditation opening you up to other people makes sense to me.https://t.co/y9WPpLq0rs
A loss of words."role of the ventral mid-insula in language processing remains unclear although this region looks similar to the insular region implicated in patients with apraxia of speech […] These regions need to be directly compared for confirmation"https://t.co/HlqPiw6DaR
A brain storm.https://t.co/WJRAlVnbtR
Repeating myself. Echolalia.https://t.co/rwAmw8PHUv
Anixety induced stuttering... so hard the words never make it out.https://t.co/SICPg3npAy
"Activity in the bilateral striatum, planum polare and left anterior insula positively co-varied with stuttering severity only before therapy, while the activity of the left rolandic operculum showed positive correlation both before and after therapy."
"Cortical plasticity associated with stuttering therapy"https://t.co/odNDqqiLbw
"Research conducted prior to the turn of the century produced evidence of heightened anxiety in people who stutter, yet findings were inconsistent and ambiguous."https://t.co/eGrd5rRlkH
Ok google, how dose the microbiome impact cortical plasticity?"In addition, delayed maturation of the gut microbiome may be associated with a prolonged period of cortical plasticity and maturation, leading to better cognitive performance."https://t.co/NKAd43K7XN
I don't stutter, I just halt and catch fire."A 2012 study showed that mindfulness meditation scaled down participants' stuttering frequency."https://t.co/fPilOBOgdY
Telling myself jokes that I don't even fully understand.https://t.co/JoRagRV4GB
Tired: Talk therapyWired: MedicationInspired: Meditation to calm your gut microbes, and eating bacteria waste as a prebiotic.Hired: Realizing all the norms around handling mental disease in western society occurred after the 1870s, co-occurring with the germ theory of disease. https://t.co/61begB6biP
The dog I live with will stutter at the mailman.https://t.co/hlDWLTNsYI
The dog I live with freaks out of the furniture is different.https://t.co/c0QCK6CZW1
I figured out the dog I live with wasn't the breed everyone thought after her sister had to be put down for an unknown neurological disorder. Poor thing had her first seizure last week. Vet prescribed CBD oil.https://t.co/c99LCSx8lk
Knowing things is torture.https://t.co/xm9CK4QYhL
"immune system affects -- and even controls -- social behavior, a new study has found. [...] The discovery could have enormous implications for neurological conditions such as autism and schizophrenia."https://t.co/6kbt7INyY8My dog butt theory of autism strike again. Shocking.
I went to Taryn's twitter page to find somehing to celebrate her new indie movie about cyborgs (@iamhuman). I saw that Rat empathy paper and now somehow I found myself reading my thread on cyber butt plugs for dogs:https://t.co/B7r2uBC27r
Just heard that our house's dog's sibling is going to be put down because of a neurodegenerative disorder causing her to loose sense of smell, eyesight, and loss of hind limb movement. She manifest first with odd mood issues & anxiety. ☹️https://t.co/QCg7yWWLIk
Before we were cyborgs, we used animals as extensions of ourselves. https://t.co/SE93U1GGzQ
Tired: Russian trained whales to spy on us.Wired: CIA using cybernetic implants in dogs to make them remote contorl.https://t.co/Xsu7IZilrh
Stuttering may be a psychological disorder as much as a biological one. If the gut-brain axis plays a role in white matter development via impact on microbiome, and meditation improves symptoms, it would explain all these shitty theories about stuttering. https://t.co/2x4qg7oZfR
A circus of fools.https://t.co/k7J2vAvI3D
What a pain in the ass >.>"They find that antibiotic-treated rats have higher level of acetaminophen glutathione conjugates in blood than untreated rats, which further suggests the gut microbial impacts on acetaminophen metabolism."https://t.co/IzAX1iTorS
Oh wow. (paracetamol aka. acetaminophen)"A total of 13 articles of more than 1,043,109 individuals were included in the meta-analysis. A statistically significant association between prenatal paracetamol exposure and child asthma risk was found."https://t.co/ZxFC9q9VPK
A strain of Lactobacillus helps prevent Tylenol from causing liver damage. https://t.co/R9P1cyNAzH
rosehips make people vomit up tylenol.https://t.co/MylXM1Jgtcno seems to know why.Looking at citations, rosehip extract changes fat deposition?https://t.co/fj8w4yGiZC
and apparently fights heart disease.https://t.co/eyAIW9rlB1and even helps with oxidative stress in Parkinson's/Alzheimer's.https://t.co/zbre88Yr9Dhuhhttps://t.co/59jAKUq218
Stutteringhttps://t.co/BORbtvT23x
What the fuck even is acetaminophen?>One mechanism researchers have kicked around is that acetaminophen blocks cyclooxygenase (COX) enzymes. These help to form prostaglandins, which are pain- and inflammation-mediating signaling molecules.https://t.co/j13ulFRz4a
TRPVwat?TRPV1"an active metabolite of paracetamol (also known as acetaminophen) —that serves as an anandamide reuptake inhibitor and COX inhibitor also serves as a potent TRPV1 agonist."https://t.co/az0gzhaVqIPain relief, you say?
"roles of the TRPV1 channel and of its structural, pharmacological and biophysical properties. [...] an overall view of the status of the discovery of potential therapeutic agents for the management of chronic and neuropathic pain."https://t.co/b0bRYDIAI2
Give Tylenol to pregnant woman! Its safe! Absolutely won't impact anandamide regulation in the infant's brain and impact immune function during vital developmental stages. I have no idea what your'e talking about. /shttps://t.co/tuR1MuGjTA
God. I want to be wrong about this."In our own data, regression was featured in 38% of cases, and we were able to show an increased likelihood for ASD from acetaminophen use, which was higher in children with regression"https://t.co/G9UyMZRkZM
Am I autistic because I was given Children's Tylenol to deal with all the ear infections I had while young? Constantly taking Theraflu when I had a chest cold?If the effect occurs in pregnant women, how can we ethically test this? https://t.co/CCWhslg97A
If the endocannabinoid system impacts Febrile Seizures https://t.co/HOV5hdCQK2Is this why we see Tylenol can help with them too? https://t.co/MIupaarsu2Why do autistics get seizures at a higher rate?
You've got to be FAAH'king kidding me"Acetaminophen and p-aminophenol are metabolized to AM404 by fatty acid amide hydrolase (FAAH) in the liver."https://t.co/H3whzD0dxWhttps://t.co/1HrqXSYLCF
So.. Animal models?This person was neat. I read thru their tweets last night.https://t.co/QLpUMXRrP6
Slept on a weird idea. Why does p-cresol smell familiar?https://t.co/qZmo5RUhLi
I woke up this morning hugging my stuffed animal - a cute little piggie I use to prevent my arm from falling asleep.Then it hit me. (not the pig, the idea...)https://t.co/vRYAFTaedB
p-cresol is what makes pigs smell like pigs.https://t.co/LKJpjImAhg
Does Tylenol make shit smell like pig?"by altering the amount of p-cresol produced, variation in either the diet or the gut bacteria could potentially exert a major influence on drug-induced responses or diseases where sulfonation has an important role."https://t.co/nlWxLXRZyZ
What of boar taint & bacteria?"Malodorants from food production animals are both public nuisances and health concerns. Skatole is also the main compound that causes boar taint, which is an offensive odor and flavor present in the meat of some male pigs"https://t.co/vj4J1WBCxq
So how do we test this? Of course. I already know the answer.https://t.co/bS9a62QcHV
We give Tylenol to pigs for fever!"Children's Tylenol (acetaminophen) 5 mg per pound of body weight every 8 hours for no more than 3 days."https://t.co/8k2Oim3KL4
We give Tyelnol to pigs for pain!"Tylenol, 5 mg per pound every 8 hours. (If you use infant’s Tylenol, 1 cc per 6 pounds). Always with food. For no more than 3 days"https://t.co/qDJlulGaiZ
So... what are the similarities between human microbes and pig microbes? https://t.co/qc4XAOO6fK
Pigs on cannabis get the munchies. 😂https://t.co/paYhrBf18Y
I wonder how much money it would be worth to invent a pig food supplement that makes pig farms not smell like pig farms.https://t.co/wXBOlmPEhQ
"And so Poincheval went to see a scientist. Eventually they cracked the flatulence code, developing a pill that makes human farts smell like flowers."https://t.co/dNsgyiEEiAI wonder? Did they down regulate indole via plant terpenes so our noses misunderstand it as roses?
Boar taint - a condition where their meat taste like literal shit, happens more with captive pigs. It happens less when you let them 'free range', which basically means you give them an ability to eat wild mushrooms and use their nose to forage as they please. ~ Self medicating?
A quick look online suggests major kinds of bacteria that produce skatole and indole, (which then possibly leaks into pig meat via a leaky-gut phenomena?), are all seemingly able to metabolize acetaminophen or downstream metabolites from that process.
Some pig.https://t.co/XWqdGbtNCD
I know there are scientists studying mental modeling of others in goats.But is anyone trying to study if pigs steal things?https://t.co/sWyEbXqmtqhttps://t.co/aKZZlahEpc https://t.co/mT0VQQR5xW
Heh, it seems pigs can learn that other pigs know where food is and bully them away from the food. After a while the bullied one starts feinting where the food is as a deception.Amazing.https://t.co/kAj7AoaRbI
"It seems that, since pigs are smart enough to tell researchers how they feel, they could be trained to understand that although a routine husbandry procedure might be frightening, it could be over relatively quickly and painlessly."https://t.co/UXGTdsoaAy
"There are a number of difficulties in developing animal models with features of autism. First, the disorder is currently defined by a set of core behavioral abnormalities rather than by objective biomarkers."https://t.co/IbIGGuFmTi
"Currently, no specified accepted animal model of and for autism has been developed, although research on primates and rodents are on peak."https://t.co/SYFQWYE8gD
"As the research in this field is largely dependent on the animal models, there is an ongoing discussion and search for the most appropriate one adequately reproducing the pathology."https://t.co/3kaikg0zme
Tylenol reduces stutteringhttps://t.co/aYXlCtoaNfTylenol induces migraine reboundshttps://t.co/nlRmiIQpHBMigraines can exhibit stutteringhttps://t.co/ETZkygme0r
haha. I bet my mom has multiple copies of TRPM8.https://t.co/XPWbHMvTil
what the fuckhttps://t.co/ClzdMYObPq
haha lmfaohttps://t.co/LfocqLwb46
Tylenol/Acetaminophen, prevents your brain from remembering? This might fuck with place cells and those interact with grid-cells.https://t.co/Vvnd983fEA
What's that? A disorder associated with white brain matter problems somehow includes risk factors associated with language problems?"Adolescent stuttering is associated with an increased risk for early-onset type 2 diabetes among men."https://t.co/c2nRytqjAI
"Two subgroups of stuttering were found, [...] characterized by indications of preonset lesions versus heredity for stuttering. [...] The increased anxiety is suggested to mainly be an effect of experiences of stuttering." https://t.co/ebhYCcipk3
"There is a solid body of literature showing the importance of conventional (nonpsychosocial) risk factors for T2D. [...] We propose that chronic activation of the physiologic stress response (PSR) increases the risk of developing T2D."https://t.co/QBzZwSOaqF
"Psychological stress, measured as psychosocial strain in the family, seems to be involved in the induction, or progression, of diabetes-related autoimmunity in the child during the 1st year of life."https://t.co/o6Rrpn1jtm
"The theory of white matter disconnection as a key aspect of stuttering was first proposed by Sommer et al. (2002), based on their findings from brain imaging. Their results indicated a localized impairment of the white matter structure" https://t.co/chSYQglEk0
"Results were taken to suggest an association between young CWS's positive emotional reactivity and stuttering, [...] seem to support the notion that emotional processes warrant inclusion in any truly comprehensive account of childhood stuttering." https://t.co/WcaMLiNpGp
I ca..ca..ca..ca.. am not able to speak my mind.https://t.co/2x4qg7GA7p
What does a fish know of water, which it swims in all it's life?https://t.co/UCKH8XKiuU
"Another major obstacle we perceived for understanding stuttering at that time was a misguided focus on [...] measurement of disfluencies as “the window through which all phenomena associated with the disorder must be observed"https://t.co/0AHK2WGCYvhttps://t.co/DgLOFZFkJh
Don't distract yourself with the words.https://t.co/9nynrlP2Nl
Hofstadter's concept of ~"analorgy as the core of cognition"We ought to expect all experience to be channeled thru a fruedian lens of bootstrapped abstractions on our early childhood experiences of pooping.Memes: Don't distract yourself with the words.https://t.co/xAjzUnGHVL
"case reports a probable immune-mediated encephalitis that resulted in acquired stuttering. [...] “slowed” oscillatory brain activity on motor skills requesting sequencing and fine coordination (e.g. speech) could result in less “synchronized” systems"https://t.co/HLQwDWAyCF
Complex oscillatory brain synchronization as a service.https://t.co/UdwtHEQ6dE
Why doe we get ourselves stuck in these local maxima of ideas?https://t.co/eQWojfisr5
Stuttering may be a psychological disorder as much as a biological one. If the gut-brain axis plays a role in white matter development via impact on microbiome, and meditation improves symptoms, it would explain all these shitty theories about stuttering. https://t.co/2x4qg7oZfR
"The mechanism of risperidone's action in stuttering, in part, appears to involve increased metabolism -- or activity -- of astrocytes in the striatum.https://t.co/0PfZ9ltRpDP2X7 -> Astrocytes.https://t.co/T8n6Y06nCJ
Risperidone, impacting astrocytes via manipulating metabolism?Wild, who could have predicted that? /shttps://t.co/8rHDIk4X0j
Cool. This preprint suggests gut bacteria might help avoid Tylenol related liver damage by way of propionic acid.https://t.co/j7gsLH119Ohttps://t.co/m73VLErbuu
"These bacteria produce carbon dioxide and a number of compounds that account for the unique odour: pungent (propionic acid), rotten-egg (hydrogen sulfide), rancid-butter (butyric acid), and vinegary (acetic acid)"https://t.co/kdvacJllKUSounds Delicioushttps://t.co/VGq4IiWZjH
"Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial"https://t.co/s7jUPiqQ9pCitation 69? about mTOR.https://t.co/yjzhdfWijDNice. https://t.co/gPfBFAe9r7
What's folate got to do with mTOR and language deficits in autism?Oh. Nothing.😇https://t.co/R354V2CacT https://t.co/82QQfBdXwM
Felt cute, might fuck around and find out later.https://t.co/KXpKVgTTLB
I wrote on bluesky about how empathy neurons in rats is related to folklore about vampirism and how garlic can help treat Alzheimer's by acting to reduce NADPH activity.https://t.co/PsRwr0J8mD